Open Access
ISSN:0327-9545(print)
ISSN:1667-5746(online)
Publication Frequency:Monthly
BIOCELL is an international, peer-reviewed, open access journal on molecular and cellular biosciences. The journal welcomes high quality original research articles, review papers, communications, perspectives, commentaries, etc. Topics of interests include but are not limited to: Cellular Biochemistry, Structural & Molecular Biology, Cellular/Molecular Biology, Immunology, Pathology & Neurobiology, Cell Signaling, Regenerative Biology & Stem Cells, Cancer Biology, RNA Biology, Genomics, Transcriptomics, Proteomics & Metabolomics, Plant Molecular & Cellular Biology.
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Refers to articles published on the journal since 2020 that have received the most frequent citation to date (Statistics provided by TSP database)
Open Access
REVIEW
BIOCELL, Vol.47, No.9, pp. 1915-1930, 2023, DOI:10.32604/biocell.2023.029564
Abstract In the present medicine world antibiotic resistance is one of the key threats to universal health coverage.
Researchers continue to work hard to combat this global health concern. Phage therapy, an age-old practice during
the early twentieth century, was outshined by the discovery of antibiotics. With the advent of widespread antibiotic
resistance, phage therapy has again redeemed itself as a potential alternative owing to its adeptness to target bacteria
precisely. Limited side effects, the ability to migrate to different body organs, a distinct mode of action, and
proliferation at the infection site, make phages a profitable candidate to replace conventional… More >
Graphic Abstract
Open Access
ARTICLE
BIOCELL, Vol.47, No.9, pp. 1931-1945, 2023, DOI:10.32604/biocell.2023.028968
Abstract Glutamine metabolism (GM) plays an important role in tumor growth and proliferation. Skin cutaneous melanoma (SKCM) is a glutamine-dependent cancer. However, the molecular characteristics and action mechanism of GM on SKCM remain unclear. Therefore, we aimed to explore the effects of GM-related genes on survival, clinicopathological characteristics, and the tumor microenvironment in SKCM. In this study, 682 SKCM samples were obtained from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Consensus clustering was used to classify SKCM samples into distinct subtypes based on 41 GM-related genes. Differences in survival, immune infiltration, clinical characteristics, and Kyoto Encyclopedia of… More >
Graphic Abstract
Open Access
ARTICLE
BIOCELL, Vol.47, No.9, pp. 1947-1964, 2023, DOI:10.32604/biocell.2023.029333
（This article belongs to this Special Issue: Natural Products for Chronic Inflammatory Diseases: Pharmacology and Toxicology)
Abstract Background: Despite its widespread therapeutic use and effectiveness, the underlying pharmacologic
mechanisms of Wendan decoction (WDD) and how it works to treat sudden deafness (SD) remain unclear. In this
study, the pharmacological mechanisms of WDD underlying SD were analyzed using network pharmacology and
molecular docking. Methods: The Traditional Chinese Medicine Systems Pharmacology Database and Analysis
Platform (TCMSP) was employed to identify the active compounds and target genes of WDD, and genes associated
with SD were screened on five databases. RGUI conducted Gene Ontology (GO) functional and the Kyoto
Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. A compound-target network was… More >
Open Access
ARTICLE
BIOCELL, Vol.47, No.9, pp. 1965-1975, 2023, DOI:10.32604/biocell.2023.030796
Abstract Objective: Through integrated bioinformatics analysis, the goal of this work was to find new, characterised N7-methylguanosine modification-related long non-coding RNAs (m7G-lncRNAs) that might be used to predict the prognosis of laryngeal squamous cell carcinoma (LSCC). Methods: The clinical data and LSCC gene expression data for the current investigation were initially retrieved from the TCGA database & sanitised. Then, using co-expression analysis of m7G-associated mRNAs & lncRNAs & differential expression analysis (DEA) among LSCC & normal sample categories, we discovered lncRNAs that were connected to m7G. The prognosis prediction model was built for the training category using univariate & multivariate COX… More >
Open Access
ARTICLE
BIOCELL, Vol.47, No.9, pp. 1977-1994, 2023, DOI:10.32604/biocell.2023.030742
Abstract Background: The development and prognosis of breast cancer are intricately linked to psychological stress. In addition, depression is the most common psychological comorbidity among breast cancer survivors, and reportedly, Fang-Xia-Dihuang decoction (FXDH) can effectively manage depression in such patients. However, its pharmacological and molecular mechanisms remain obscure. Methods: Public databases were used for obtaining active components and related targets. Main active components were further verified by ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UPLC-HRMS). Protein–protein interaction and enrichment analyses were taken to predict potential hub targets and related pathways. Molecule docking was used to understand the interactions between main compounds and hub… More >
Open Access
ARTICLE
BIOCELL, Vol.47, No.9, pp. 1995-2008, 2023, DOI:10.32604/biocell.2023.024591
（This article belongs to this Special Issue: Cell-Based Regenerative Therapies)
Abstract Background: Mesenchymal stem cell (MSC)-derived exosomes are closely related to pyroptosis in diabetic
nephropathy (DN). This study aimed to explore the protective effect of exosomal miR-30a-5p on podocyte pyroptosis
in DN. Methods: Streptozotocin was used to establish the mouse model of DN. Human bone marrow MSC-derived
exosomes were extracted and identified via transmission electron microscopy, nanoparticle tracking analysis, and
western blotting. MiR-30a-5p mimics and non-control (NC) mimics were transfected into MSCs and podocytes, and
exosomes were isolated from the MSCs. High glucose (HG)-induced podocyte model was established to determine the
effect of exosomal miR-30a-5p on pyroptosis and inflammation in vitro.… More >
Open Access
ARTICLE
BIOCELL, Vol.47, No.9, pp. 2009-2026, 2023, DOI:10.32604/biocell.2023.029269
（This article belongs to this Special Issue: Herbal Active Ingredients: Potential for the Prevention and Treatment of Cancer)
Abstract Non-small cell lung cancer (NSCLC) is a malignant tumor with high incidence worldwide. Triptolide (TP), extracted from Tripterygium wilfordii Hook F, exhibits potent broad-spectrum antitumor activity. Although some mechanisms through which TP inhibits NSCLC are well understood, those that involve ribosomal proteins remain yet to be understood. In this study, the transcriptome and proteome were integrated and analyzed. Our data indicated ribosomal protein L4 (RPL4) to be a core hub protein in the protein-protein interaction network. RPL4 is overexpressed in NSCLC tissues and cells. Transfection with siRPL4 or TP treatment alone arrested the cell cycle in the G1 phase, induced… More >
Graphic Abstract
Open Access
ARTICLE
BIOCELL, Vol.47, No.9, pp. 2027-2035, 2023, DOI:10.32604/biocell.2023.029277
Abstract Background: The lung is one of the primary target organs of hydrogen sulfide (H2S), as exposure to H2S can cause acute lung injury (ALI) and pulmonary edema. Dexamethasone (Dex) exerts a protective effect on ALI caused by exposure to toxic gases and is commonly used in the clinic; however, the underlying mechanisms remain elusive, and the dose is unclear. Methods: In vivo experiments: divided C57BL6 mice into 6 groups at random, 12 in each group. The mice were exposed to H2S for 3 h and 5 or 50 mg/kg Dex pretreated before exposure, sacrificed 12 h later. The morphological changes… More >
Open Access
ARTICLE
BIOCELL, Vol.47, No.9, pp. 2037-2049, 2023, DOI:10.32604/biocell.2023.028863
（This article belongs to this Special Issue: Application of Deep Learning in Cancer)
Abstract Introduction: Sulfatase 2 (SULF2), an endogenous extracellular sulfatase, can remove 6-O-sulfate groups of glucosamine residues from heparan sulfate (HS) chains to modulate the Wnt/β-catenin signaling pathway, which plays an important role in both liver carcinogenesis and embryogenesis. Side population (SP) cells are widely identified as stem-like cancer cells and are closely related to carcinoma metastasis, recurrence, and poor patient prognosis. However, the roles of SULF2 in SP cells of hepatomas are unclear, and the underlying mechanism is undefined. Objectives: This study aimed to compare the heterogeneity between SP cells and non-side population (NSP) cells derived from three different liver cancer… More >
Graphic Abstract
Open Access
ARTICLE
BIOCELL, Vol.47, No.9, pp. 2051-2058, 2023, DOI:10.32604/biocell.2023.029644
Abstract Background: Women with obesity have higher risk of adverse pregnancy outcomes, including preeclampsia (PE). Late-gestational hypertension, aberrant fetoplacental development, and fetal growth restriction (FGR), hallmarks of PE, are observed spontaneously in BPH/5 mice. Similar to obese preeclamptic women, BPH/5 mice have higher visceral white adipose tissue (WAT) and circulating leptin. We hypothesized that attenuation of maternal obesity and serum leptin in pregnant BPH/5 mice will improve fetoplacental development by decreasing hypoxia markers and leptin expression at the maternal-fetal interface. Methods: To test this hypothesis, BPH/5 mice were fed ad libitum (lib) and pair-fed (PF) to C57 ad lib controls beginning… More >
Open Access
ARTICLE
BIOCELL, Vol.47, No.9, pp. 2059-2068, 2023, DOI:10.32604/biocell.2023.030565
（This article belongs to this Special Issue: Bioinformatics Study of Diseases)
Abstract Objective: Key genes were screened to analyze molecular mechanisms and their drug targets of endometriosis
by applying a bioinformatics approach. Methods: Gene expression profiles of endometriosis and healthy controls were
obtained from the Gene Expression Omnibus database. Significant differentially expressed genes were screened using
the limma package. Correlation pathways were screened by Spearman correlation analysis on the echinoderm
microtubule-associated protein-like 4 (EML4) and enrichment in endometriosis pathways and estimated by the GSVA
package. Immune characteristics were assessed by the “ESTIMATE” R package. Potential regulatory pathways were
determined by enrichment analysis. The SWISS-MODE website was used in homology modeling with EML4… More >
Graphic Abstract
Open Access
ARTICLE
BIOCELL, Vol.47, No.9, pp. 2069-2080, 2023, DOI:10.32604/biocell.2023.029989
Abstract Background: The underlying mechanism of sciatic nerve injury (SNI) is a common motor functional disorder, necessitates further research. Methods: A rat model of SNI was established, with the injury group subjected to compressive injury of the right sciatic nerve exposed at the midpoint of the thigh and the sham surgery group undergoing the same surgical procedure. An oxygen-glucose deprivation model was employed to simulate in vitro SNI in PC12 cells. Following data acquisition and quality control, differentially expressed proteins (DEPs) in each model were identified through differential analysis, and enrichment analysis was used to explore the potential functions and pathways… More >
Open Access
ARTICLE
BIOCELL, Vol.47, No.9, pp. 2081-2099, 2023, DOI:10.32604/biocell.2023.029986
Abstract Background: This study was aimed at identifying natural killer (NK) cell-related genes to design a risk prognosis model for the accurate evaluation of gastric cancer (GC) prognosis. Methods: We obtained NK cell-related genes from various databases, followed by Cox regression analysis and molecular typing to identify prognostic genes. Various immune algorithms and enrichment analyses were used to investigate the mutations, immune status, and pathway variations among different genotypes. The key prognostic genes were assessed using the least absolute shrinkage and selection operator (Lasso) regression analysis and univariate Cox regression analysis. Thereafter, the risk score (RS) prognosis model was constructed based… More >
Graphic Abstract
Open Access
ARTICLE
BIOCELL, Vol.47, No.9, pp. 2101-2113, 2023, DOI:10.32604/biocell.2023.029581
（This article belongs to this Special Issue: Plant Cell Physiology and Stress Biology)
Abstract Background: Plant root-knot nematode (RKN) disease is a serious threat to agricultural production across the
world. Meloidogyne incognita is the most prominent pathogen to the vegetables and cash crops cultivated. Arachis
hypogaea can effectively inhibit M. incognita, but the underlying defense mechanism is still unclear. Methods: In our
study, the chemotaxis and infestation of the second-stage juveniles (J2s) of M. incognita to A. hypogaea root tips were
observed by the Pluronic F-127 system and stained with sodium hypochlorite acid fuchsin, respectively. The
transcriptome data of A. hypogaea roots with non-infected or infected by J2s were analyzed. Results: The J2s could… More >
Open Access
ARTICLE
BIOCELL, Vol.47, No.9, pp. 2115-2123, 2023, DOI:10.32604/biocell.2023.030364
（This article belongs to this Special Issue: Cellular Signal Transduction in Biological Activities)
Abstract Background: The regulatory genes related to lipid metabolism affect the intramuscular fat (IMF) content and improve meat quality traits. Mediator Complex Subunit 4 (MED4), a vitamin D receptor protein, affects vitamin D, livestock growth, carcass traits, and triglyceride deposition. However, the physiological function of the MED4 gene on bovine adipocyte differentiation remains unknown. Methods: This study explored the function of the MED4 gene in preadipocyte differentiation in Chinese Red Steppe cattle. The overexpression plasmid and the interference sequences of the MED4 gene were constructed to detect the effects of the MED4 gene on adipogenesis and biomakers using quantitative polymerase chain… More >
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