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Exploring the Cellular Mechanisms of Neurodegenerative Diseases

Submission Deadline: 31 August 2024 Submit to Special Issue

Guest Editors

Prof. Kamil Kuca, Department of Chemistry, Faculty of Science, University of Hradec Kralove, Czech Republic.
Dr. Eugenie Nepovimova, Department of Chemistry, Faculty of Science, University of Hradec Kralove, Czech Republic
Prof. Rohit Sharma, Department of Rasa Shastra and Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Science, Banaras Hindu University, India

Summary

Neurodegenerative diseases (NDDs) pose a significant challenge to public health and have far-reaching implications for affected individuals and their families. These disorders, which include Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, involve the progressive loss of neurons and lead to severe cognitive and motor impairments. In recent years, a growing body of research has uncovered critical insights into the cellular and molecular underpinnings of NDDs.

 

This special issue aims to consolidate and showcase cutting-edge research on the cellular mechanisms driving NDDs, shedding light on disease pathogenesis and therapeutic potential. It will encompass a wide range of topics, including, but not limited to:

-Pathological Protein Aggregation: Investigating the molecular basis of protein misfolding and aggregation in NDDs, with a focus on proteins like alpha-synuclein, tau, and amyloid-beta.

-Cellular Dysfunction: Analyzing the impact of NDDs on synaptic and neuronal network function, cytoskeletal abnormalities, aberrant proteostasis, and altered energy homeostasis.

-Genetic and Molecular Factors: Examining the genetic and biochemical pathways that contribute to NDDs, including DNA and RNA defects, inflammation, and oxidative stress.

-Neuroinflammation: Exploring the role of neuroinflammation in Alzheimer's disease and other NDDs, with a focus on mechanisms and clinical applications.

-Gut-Brain Axis: Investigating the influence of the gut microbiota, particularly the role of pathogens like Helicobacter pylori, on NDD pathogenesis.

-Molecular Mechanisms: Delving into the cellular and molecular mechanisms underlying neuroinflammation and disease progression in NDDs, with a specific focus on the role of microglia and astrocytes.

 

We welcome contributions from researchers, scientists, and experts in the field of neurodegenerative diseases and cell biology. Manuscripts can include original research articles, reviews, and perspectives. This special issue will serve as a valuable resource for the scientific community, consolidating recent advancements and insights in the field of NDDs. By focusing on the intricate cellular biology of these diseases, we hope to facilitate progress towards effective treatments and interventions that will significantly impact the lives of those affected by NDDs.


Keywords

neurodegenerative disorders, protein aggregation, cellular dysfunction, genetic and molecular factors, neuroinflammation, neuroprotection, neurotoxicity, natural products, bioactive compounds, oxidative stress, omics, biomarkers, Parkinson’s disease, Alzheimer’s disease, anti-inflammatory agents

Published Papers


  • Open Access

    REVIEW

    Exploring the vital role of microglial membrane receptors in Alzheimer’s disease pathogenesis: a comprehensive review

    JUN-FENG ZHAO, YI-RAN JIANG, TIAN-LIN GUO, YONG-QING JIAO, XUN WANG
    BIOCELL, DOI:10.32604/biocell.2024.050120
    (This article belongs to the Special Issue: Exploring the Cellular Mechanisms of Neurodegenerative Diseases)
    Abstract Neurodegenerative diseases constitute a broad category of diseases caused by the degeneration of the neurons. They are mainly manifested by the gradual loss of neuron structure and function and eventually can cause death or loss of neurons. As the global population ages rapidly, increased people are being diagnosed with neurodegenerative diseases. It has been established that the onset of Alzheimer’s disease (AD) is closely linked with increasing age and its major pathological features include amyloid-beta plaques (Aβ), Tau hyperphosphorylation, Neurofibrillary tangles (NFTs), neuronal death as well as synaptic loss. The involvement of microglia is crucial… More >

  • Open Access

    REVIEW

    Molecular and cellular mechanisms of neuroprotection by oligopeptides from snake venoms

    CARLOS ALBERTO-SILVA, BRENDA RUFINO DA SILVA
    BIOCELL, DOI:10.32604/biocell.2024.050443
    (This article belongs to the Special Issue: Exploring the Cellular Mechanisms of Neurodegenerative Diseases)
    Abstract Venom snake-derived peptides have multiple biochemical, pharmacological, and toxicological profiles, allowing for the discovery of new medicinal products and therapeutic applications. This review specifically examines the fundamental elements of neuroprotection offered by different oligopeptides derived from snake venom. It also includes a brief evaluation of short peptides that are being considered as potential therapeutic agents. Proline-rich peptides and tryptophyllin family peptides isolated from the crude venom of Viperidae family snakes, specifically Bothrops atrox, Bothrops jararaca, and Bothrops moojeni, have been shown to have pro-survival properties, the ability to reduce oxidative stress, and the ability to promote cell viability More >

  • Open Access

    REVIEW

    Pathogenic genes associated with Parkinson’s disease: molecular mechanism overview

    TINGTING LIU, YIWEI HAO, LIFENG ZHAO
    BIOCELL, Vol.48, No.5, pp. 707-729, 2024, DOI:10.32604/biocell.2024.049130
    (This article belongs to the Special Issue: Exploring the Cellular Mechanisms of Neurodegenerative Diseases)
    Abstract Parkinson’s disease (PD) is a common neurodegenerative disease in the elderly, accounting for more than 1% of the population aged 65 years. Monogenic inheritance is relatively rare in PD, accounting for approximately 5% to 10% of PD patients, and there is a growing body of evidence suggesting that multiple genetic risk factors play a significant role in the pathogenesis of PD. Several groups have identified and reported a number of genes carrying mutations associated with affected family members. Mutated genes associated with PD are also candidates for idiopathic PD, and these genes may also carry… More >

  • Open Access

    REVIEW

    Exercise and exerkine upregulation: Brain-derived neurotrophic factor as a potential non-pharmacological therapeutic strategy for Parkinson’s disease

    VIRAAJ VISHNU PRASAD, JENNIFER SALLY SAMSON, VENKATACHALAM DEEPA PARVATHI
    BIOCELL, Vol.48, No.5, pp. 693-706, 2024, DOI:10.32604/biocell.2024.048776
    (This article belongs to the Special Issue: Exploring the Cellular Mechanisms of Neurodegenerative Diseases)
    Abstract Physical activity and exercise have several beneficial roles in enhancing both physiological and psychological well-being of an individual. In addition to aiding the regulation of aerobic and anaerobic metabolism, exercise can stimulate the synthesis of exerkine hormones in the circulatory system. Among several exerkines that have been investigated for their therapeutic potential, Brain-derived neurotrophic factor (BDNF) is considered the most promising candidate, especially in the management of neurodegenerative diseases. Owing to the ability of physical activity to enhance BDNF synthesis, several experimental studies conducted so far have validated this hypothesis and produced satisfactory results at More >

    Graphic Abstract

    Exercise and exerkine upregulation: Brain-derived neurotrophic factor as a potential non-pharmacological therapeutic strategy for Parkinson’s disease

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