- OPEN ACCESS VIEWPOINT
- Nitric oxide and hydrogen sulfide share regulatory functions in higher plant events
- BIOCELL, Vol.46, No.1, pp. 1-5, 2022, DOI:10.32604/biocell.2021.017300
- Abstract Nitric oxide (NO) and hydrogen sulfide (H2S) are two molecules that share signaling properties in plant and animal cells. NO and H2S originate two families of derived molecules designated reactive nitrogen and sulfur species (RNS and RSS, respectively). These molecules are responsible for certain protein regulatory processes through posttranslational modifications (PTMs), being the most remarkable S-nitrosation and persulfidation, which affect the thiol group of cysteine residues. NO and H2S can also exert regulatory functions due to their interaction through the iron present in proteins that contain heme groups or iron-sulfur clusters, as reported mainly in animal cells. However, the available… More
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- Single-cell systems neuroscience: A growing frontier in mental illness
- BIOCELL, Vol.46, No.1, pp. 7-11, 2022, DOI:10.32604/biocell.2022.017680
- Abstract The development of effective treatments for psychiatric disease has been disappointing in recent decades given the advancements in neuroscience. Moreover, rising rates of mental illness such as addiction and depression compel scientists and physicians to discover novel and creative solutions. One such approach that has proven effective is systems neuroscience: A focus on networks as opposed to mechanism. Further, investigation at the single-cell and circuit level is likely to be fruitful in such endeavors as this resolution describes the functional psychopathology that allows for intervention. More
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- miR-153 as biomarker for cancer—functional role as tumor suppressor
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BIOCELL, Vol.46, No.1, pp. 13-26, 2022, DOI:10.32604/biocell.2022.016953
(This article belongs to this Special Issue: Noncoding RNAs & Associated Human Diseases) - Abstract MicroRNA-153 (miR-153), belongs to a class of small non-coding RNA. It is a critical regulator of gene expression at the post-transcriptional level which interacts with the functional mRNA at 3’UTR region and suppresses the expression of the mRNA. More recently, it has become apparent that changes in the miR-153 expression lead to invasion, metastasis, angiogenesis and various types of tumor progression. This review summarizes the connection between dysregulation of miR-153 and various types of cancer progression. miR-153 regulates various signaling pathways to inhibit the proliferation and induce apoptosis in the cancer cell and also show synergistic activity with anticancer drugs.… More
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- Understanding the role of miRNAs in the pathogenesis of brain arteriovenous malformations
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BIOCELL, Vol.46, No.1, pp. 27-35, 2022, DOI:10.32604/biocell.2022.016288
(This article belongs to this Special Issue: Noncoding RNAs & Associated Human Diseases) - Abstract Brain arteriovenous malformations (AVMs) are abnormal vessels that are prone to rupture, causing life-threatening intracerebral hemorrhage (ICH). Understanding the molecular basis of pathogenesis, timely diagnosis, and treatment of brain AVMs are some of the urgent problems in neurosurgery. MicroRNAs (miRNAs) are small endogenous RNAs that regulate gene-expression posttranscriptionally. MiRNAs are involved in almost all biological processes, including cell proliferation, apoptosis, and cell differentiation. Recent studies have shown that miRNAs can be involved in brain AVMs formation and rupture. There are also extracellular forms of miRNAs. Circulating miRNAs have been detected in the blood circulation and other body fluids. Owing to… More
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- Emerging environmental stressors and oxidative pathways in marine organisms: Current knowledge on regulation mechanisms and functional effects
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BIOCELL, Vol.46, No.1, pp. 37-49, 2022, DOI:10.32604/biocell.2022.017507
(This article belongs to this Special Issue: Oxidative Stress in Aquatic Organisms) - Abstract Oxidative stress is a critical condition derived from the imbalance between the generation of reactive oxygen species and the sophisticated network of antioxidant mechanisms. Several pollutants and environmental factors can affect this system through connected mechanisms, indirect relationships, and cascade effects from pre-transcriptional to catalytic level, by either enhancing intracellular ROS formation or impairing antioxidant defenses. This review summarizes the current knowledge on the pro-oxidant challenges from emerging environmental stressors threatening marine organisms, such as pharmaceuticals, microplastics and climate-related ocean changes. Emphasis will be placed on oxidative pathways, including signaling proteins and transcription factors involved in regulation of antioxidant responsiveness.… More
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- Metformin and colorectal cancer
- BIOCELL, Vol.46, No.1, pp. 51-59, 2022, DOI:10.32604/biocell.2022.017565
- Abstract Colorectal cancer (CRC) is one of the main causes of cancer-related mortality in the developed world despite recent developments in detection and treatment. Several epidemiological studies indicate that metformin, a widely prescribed antidiabetic drug, exerts a protective effect on different cancers including CRC. Furthermore, a recent double-blind placebo-controlled, randomized trial showed that metformin significantly decreased colorectal adenoma recurrence. Studies exploring the mechanism of action of metformin in cells derived from different types of cancers reported many effects including respiratory chain complex 1 inhibition, Akt phosphorylation inhibition, ATP depletion, PKA activation and Wnt signaling inhibition. However, many of these results were… More
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- Dengue virus infection: A review of advances in the emerging rapid detection methods
- BIOCELL, Vol.46, No.1, pp. 61-74, 2022, DOI:10.32604/biocell.2022.016392
- Abstract Dengue virus infections are increasing worldwide generally and in Asia, Central and South America and Africa, particularly. It poses a serious threat to the children population. The rapid and accurate diagnostic systems are essentially required due to lack of effective vaccine against dengue virus and the progressive spread of the dengue virus infection. The recent progress in developing micro- and nano-fabrication techniques has led to low cost and scale down the biomedical point-of-care devices. Starting from the conventional and modern available methods for the diagnosis of dengue infection, this review examines several emerging rapid and point-of-care diagnostic devices that hold… More
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- An active RUNX1-ID1/ID3 axis governs differentiation and chemoresistance of cancer stem cell population in epithelial ovarian cancer cells
- BIOCELL, Vol.46, No.1, pp. 75-86, 2022, DOI:10.32604/biocell.2022.016346
- Abstract Progression, relapse, and therapy resistance are the most challenging features of cancer therapy that have been postulated to be driven by Cancer Stem Cell (CSC) population. This enigmatic subpopulation of cancer cells has therefore emerged as promising therapeutic candidate. We earlier reported enrichment of CSC-like side population (SP) with increasing resistance towards Cisplatin and Paclitaxel either alone or in combination in epithelial ovarian cancer (EOC) cells. This SP population is a small proportion of the total population of cancer cells characterised with high expression of drug transporters, a unique feature of stem cells and thereby can be isolated through their… More
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- Proteome-wide screening for the analysis of protein targeting of Chlamydia pneumoniae in endoplasmic reticulum of host cells and their possible implication in lung cancer development
- BIOCELL, Vol.46, No.1, pp. 87-95, 2022, DOI:10.32604/biocell.2022.016509
- Abstract Available reports have confirmed a link between bacterial infection and the progression of different types of cancers, including colon, lungs, and prostate cancer. Here we report the Chlamydia pneumonia proteins targeting in endoplasmic reticulum (ER) using in-silico approaches and their possible role in lung cancer etiology. We predicted 48 proteins that target human ER, which may be associated with protein folding and protein-protein interactions during infection. The results showed C. pneumoniae proteins targeting human ER and their implications in lung cancer growth. These targeted proteins may be involved in competitive interactions between host and bacterial proteins, which may change the… More
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- Construction and validation of prognostic model based on autophagy-related lncRNAs in gastric cancer
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BIOCELL, Vol.46, No.1, pp. 97-109, 2022, DOI:10.32604/biocell.2021.015608
(This article belongs to this Special Issue: Computational Models in Non-Coding RNA and Human Disease) - Abstract Gastric cancer (GC) is one of the most common cancer worldwide. Although emerging evidence indicates that autophagy-related long non-coding RNA (lncRNA) plays an important role in the progression of GC, the prognosis of GC based on autophagy is still deficient. The Cancer Genome of Atlas stomach adenocarcinoma (TCGA-STAD) dataset was downloaded and separated into a training set and a testing set randomly. Then, 24 autophagy-related lncRNAs were found strongly associated with the survival of the TCGA-STAD dataset. 11 lncRNAs were selected to build the risk score model through the least absolute shrinkage and selection operator (LASSO) regression. Every patient got… More
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- In Silico analysis and linking of metabolism-related genes with the immune landscape in head and neck squamous cell carcinoma
- BIOCELL, Vol.46, No.1, pp. 111-125, 2022, DOI:10.32604/biocell.2022.016612
- Abstract Metabolic reprogramming and immunologic suppression are two critical characteristics promoting the progression of head and neck squamous cell carcinoma (HNSCC). The integrative analysis of all the metabolism-related genes (MRGs) in HNSCC is lacking and the interaction between the metabolism and the immune characteristics also requires more exploration to uncover the potential mechanisms. Therefore, this study was designed to establish a prognostic signature based on all the MRGs in HNSCC. Genes of HNSCC samples were available from the TCGA and GEO databases while the MRGs were retrieved from a previous study. Ultimately 4 prognostic MRGs were selected to construct a model… More
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- Calcium chloride linked camel milk derived casein nanoparticles for the delivery of sorafenib in hepatocarcinoma cells
- BIOCELL, Vol.46, No.1, pp. 127-136, 2022, DOI:10.32604/biocell.2021.015932
- Abstract Sorafenib, a multikinase inhibitor used for the treatment of hepatocellular carcinoma, is limited by its low oral bioavailability. To overcome this drawback, we have developed novel camel milk casein-derived nanoparticles as a drug delivery system. Camel milk casein is not only biocompatible on oral administration but is actually a dietary protein of pharmaceutical relevance. Casein is used because of its amphiphilic nature, self-assembling property, ability to show sustained release, and capability of encapsulating both hydrophilic and hydrophobic drugs. In this study, camel milk casein nanoparticles loaded with sorafenib were developed and characterized. Characterization of casein nanoparticles was done by dynamic… More
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- Hyperbaric oxygen protects against PC12 and H9C2 cell damage caused by oxygen–glucose deprivation/reperfusion via the inhibition of cell apoptosis and autophagy
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BIOCELL, Vol.46, No.1, pp. 137-148, 2022, DOI:10.32604/biocell.2022.016807
(This article belongs to this Special Issue: Cellular Biomechanics in Health and Diseases) - Abstract In this study, we investigated the protective effect of hyperbaric oxygen (HBO) on PC12 and H9C2 cell damage caused by oxygen-glucose deprivation/reperfusion and its possible mechanism. PC12 and H9C2 cell oxygen-glucose deprivation/reperfusion model were established. Cells were divided into a control group, model group, hyperbaric air (HBA) group and HBO group. The cell viability was detected by the CCK8 assay. Hoechst 33342 and PI staining assays and mitochondrial membrane potential (MMP) assays were used to detect cell apoptosis. The ultrastructure of cells, including autophagosomes, lysosomes, and apoptosis, were examined using a transmission electron microscope. The expression of autophagy-related proteins was… More
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- HSA-MIR-203/MyD88 axis mediates the protective effect of hispidulin on LPS-induced apoptosis in a human renal tubular epithelial line, HK-2
- BIOCELL, Vol.46, No.1, pp. 149-158, 2022, DOI:10.32604/biocell.2021.013027
- Abstract Acute kidney injury (AKI), commonly occurring as complications of sepsis, cardiac surgery, and liver or kidney transplantation, is a critical care syndrome. It is well known that lipopolysaccharide (LPS) shock is a common triggering factor for AKI. This study is aimed to examine the effect of flavonoid compound hispidulin on LPS-induced AKI. For this, renal tubular epithelial cell HK-2 was treated with LPS to establish an in vitro model of AKI. The effect of hispidulin on HK-2 cell viability was examined using CCK-8 assay. Cell apoptosis was determined by TUNEL and flow cytometry. Apoptosis marker proteins were determined by using… More
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- CD34+ CD38- subpopulation without CD123 and CD44 is responsible for LSC and correlated with imbalance of immune cell subsets in AML
- BIOCELL, Vol.46, No.1, pp. 159-169, 2022, DOI:10.32604/biocell.2021.014139
- Abstract Acute myeloid leukemia (AML) is regarded as a stem cell disease. However, no one unique marker is expressed on leukemia stem cells (LSC) but not on leukemic blasts nor normal hematopoietic stem cells (HSC). CD34+ CD38- with or without CD123 or CD44 subpopulations are immunophenotypically defined as putative LSC fractions in AML. Nevertheless, markers that can be effectively and simply held responsible for the intrinsical heterogeneity of LSC is still unclear. In the present study, we examined the frequency of three different LSC subtypes (CD34+ CD38-, CD34+ CD38- CD123+ , CD34+ CD38- CD44+ ) in AML at diagnosis. We then… More
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- Forkhead box protein O1 (FoxO1) regulates lipids metabolism and cell proliferation mediated by insulin and PI3K-Akt-mTOR pathway in goose primary hepatocytes
- BIOCELL, Vol.46, No.1, pp. 171-183, 2022, DOI:10.32604/biocell.2022.015409
- Abstract In order to explore the role of forkhead box protein O1 (FoxO1) in the lipid metabolism and cell proliferation, goose primary hepatocytes were isolated and incubated with insulin or PI3K-Akt-mTOR pathway dual inhibitor NVP-BEZ235, and then transfected with FoxO1 interference plasmid. The related parameters of lipid metabolism and cell proliferation were measured. The results firstly showed that FoxO1 interference increased the intracellular TG and lipids concentration (P < 0.05); and increased the proliferative index (PI), cell DNA synthesis, protein expression of Cyclin D1 in goose primary hepatocytes (P < 0.05). Secondly, the co-treatment of insulin and FoxO1 interference increased the… More
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- Two approaches for calculating female fetal DNA fraction in noninvasive prenatal testing based on size analysis of maternal DNA fragments
- BIOCELL, Vol.46, No.1, pp. 185-193, 2022, DOI:10.32604/biocell.2021.015301
- Abstract The concentration of cell-free fetal DNA fragments should be detected before noninvasive prenatal testing (NIPT). The fetal DNA molecules have significant clinical potential in determining the overall performance of NIPT and clinical interpretation. It is important to measure fetal DNA fraction before NIPT. However, there is still little research on how to calculate the concentration of female fetuses. Two estimation approaches were proposed to calculate fetal DNA fraction, including the fragments size-based approach, aneuploid-based approach, which are all approaches based on chromosome segments. Based on high-throughput sequencing data, two approaches to calculate the DNA fraction of male fetuses were tested… More
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- Transcriptome profile analysis of the accompanying migratory parasitic wasp Aenasius bambawalei (= Aenasius arizonensis girault) (Hymenoptera: Encyrtidae): Genes related to fertilization involved at different stage of ovary development
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BIOCELL, Vol.46, No.1, pp. 195-205, 2022, DOI:10.32604/biocell.2022.016563
(This article belongs to this Special Issue: Reproductive Health and Embryonic Development) - Abstract Age-related declines in fertilization success have been reported for a wide range of species. The fertilization of parasitic wasps is closely related to egg production and sperm storage. Aenasius bambawalei (Hymenoptera: Encyridae) is a key parasitic wasp of the important invasive mealybug Phenacoccus solenopsis (Hemiptera: Pseudococcidae). The female offspring ratio of this parasitic wasp was declined with parental age in mass rearing under laboratory conditions. To investigate the molecular mechanisms involved in the reproduction of A. bambawalei, an extensive analysis of the impact of age on transcriptome profile of mated ovaries of this wasp was performed by comparing the gene… More
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- STMN1 promotes the proliferation and inhibits the apoptosis of acute myeloid leukemiacells by activating the PI3K/Akt pathway
- BIOCELL, Vol.46, No.1, pp. 207-218, 2022, DOI:10.32604/biocell.2021.014728
- Abstract Recent studies have shown that the microtubule disrupting protein Stathmin 1 (STMN1) is differentially expressed in AML patients and healthy control. The aim of this study was to explore the effects and molecular mechanism of STMN1 in AML. Here, the expression of STMN1 in peripheral blood cells (PBMCs) and bone marrow of AML patients and healthy volunteers was detected by RT-PCR and Western blot. STMN1 expression was regulated by transfected with STMN1 overexpressed plasmid or shRNA in two human leukemia cell lines K562 and HL60. Cell proliferation was examined by CCK8 and Edu staining. Annexin V and TUNEL assays were… More
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- Evaluation of the hepatoprotective and antioxidant effects of Tegillarca granosa flesh body extract against potassium bromide toxicity via targeting the histomorphometry, chromosomal and expressions of TGF-β1, VEGF and COX-2 genes in rats
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BIOCELL, Vol.46, No.1, pp. 219-234, 2022, DOI:10.32604/biocell.2022.017623
(This article belongs to this Special Issue: Mesenchymal Stem Cells, Secretome and Biomaterials: Regenerative Medicine Application) - Abstract The hepatotoxic effect of potassium bromide (KBr) on rat liver tissues were determined, as well as the potential protective effect of Tegillaraca granosa (T. granosa) flesh body extract. Twenty adult male albino rats were equally distributed into four groups; Group (I) treated with physiological saline (control group), Group (II) was orally gavaged by 200 mg/kg of T. granosa body extract day after day, Group (III) was intoxicated by KBr (150 mg/kg bwt day after day orally) and finally, Group (IV) was given a combination of T. granosa flesh body extract plus KBr with similar doses in the second and third… More
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- The neuroprotection of electro-acupuncture via the PGC-1α/TFAM pathway in transient focal cerebral ischemia rats
- BIOCELL, Vol.46, No.1, pp. 235-245, 2022, DOI:10.32604/biocell.2022.014997
- Abstract ATP depletion is one of the pathological bases in cerebral ischemia. Electro-acupuncture (EA) is widely used in clinical practice for ischemia. However, the mechanism of EA remains unclear. The purpose of this study was to investigate whether EA could activate the AMPK/PGC-1α/TFAM signaling pathway and, consequently, increase the preservation of ATP in rats with ischemia. In this study, 48 rats were randomly divided into four groups as a sham-operation control group (sham group), a middle cerebral artery occlusion group (MCAO group), an EA group, and an EA group blocked by the AMPK inhibitor compound C (EA + CC group) (N… More
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- Antimicrobial activities of three seaweeds extract against some human viral and bacterial pathogens
- BIOCELL, Vol.46, No.1, pp. 247-261, 2022, DOI:10.32604/biocell.2022.015966
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Abstract
Microbial infections cause complicated health influences along with bad economic impacts. In the present investigation, three dominant seaweeds namely, Amphiroa anceps, Corallina officinalis and Sargassum filipendula were collected from different Egyptian sites at the Red Sea and Mediterranean Sea during autumn 2019. Organic extracts of the three algae were screened for their antibacterial activity against three pathogenic bacteria Salmonella typhiimurium, Staphylococcus aureus and Escherichia coli, in addition to in vitro antiviral activity against Rotavirus (RV), and Coxsackie virus B3 (CVB3) that cause severe diseases in human. Organic extract of A. anceps, C. officinalis and S. filipendula inhibit E. coli cells… More
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- Effect of strawberry vein banding virus and strawberry mottle virus co-infection on the growth and development of strawberry
- BIOCELL, Vol.46, No.1, pp. 263-273, 2022, DOI:10.32604/biocell.2022.016306
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Abstract
Strawberry mottle virus (SMoV) and strawberry vein banding virus (SVBV) cause diseases on strawberry plants, but the effect of coinfection of SMoV and SVBV on the growth, development, and defense system of strawberry (Fragaria × ananassa Duchesne) remains unknown. We investigated the effect of SMoV and SVBV co-infection on strawberry cultivar ‘Benihope’. The results showed that stem diameter, leaf size, leaf number, relative chlorophyll content, total chlorophyll content, photosynthetic parameters, and stomatal aperture of SMoV and SVBV co-infected strawberry (VIS) plants were in a weaker level than uninfected control plants, indicating that viruses inhibited the growth and photosynthesis of strawberry… More
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- Ultrastructural analysis of sperm from the genus Idarnes (Hymenoptera: Chalcidoidea, Sycophaginae)
- BIOCELL, Vol.46, No.1, pp. 275-283, 2022, DOI:10.32604/biocell.2022.016603
- Abstract In this study, the sperm ultrastructure of three species of Idarnes genus was investigated using light and transmission electron microscopy. Spermatozoon morphology of the three species was similar to that of most Chalcidoidea, with helicoidally twisted nucleus and flagellum. The head region consists of an acrosome and a nucleus; the nucleus-flagellum transition region characterized by the presence of mitochondrial derivatives and the centriolar adjunct; a flagellum region, which includes the axoneme with microtubular arrangement 9 + 9 + 2 and two mitochondrial derivatives. However, the sperm of these three species exhibit features that discriminate one species from each other: (1)… More
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- Differential metabolome landscape of Kadsura coccinea fruit tissues and potential valorization of the peel and seed tissues
- BIOCELL, Vol.46, No.1, pp. 285-296, 2022, DOI:10.32604/biocell.2021.016253
- Abstract Kadsura coccinea (Lem.) is a woody wine plant with a peculiar fruit enriched in important health-promoting compounds. The non-editable part of the fruit, i.e., the seed and peel, represents more than 60% of the fruit and is considered a biowaste. This significantly restricts the development of the K. coccinea fruit industry. Clarifying the metabolic components of the different fruit parts can help to improve the utilization rate and valorization of K. coccinea. Herein, we evaluated K. coccinea fruit peel, pulp, and seed using widely-targeted metabolomics and quantified a set of 736 bioactive compounds from 11 major metabolite classes. The most… More
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