Nitric oxide (NO) and hydrogen sulfide (H2S) are two signaling molecules that are endogenously generated in plant cells under physiological and stressful conditions. They perform their functions either through post-translational modifications (PTMs) of proteins as well as their interaction with other signaling molecules such as hydrogen peroxide (H2O2) or melatonin as well as with phytohormones.
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FRANCISCO J. CORPAS*, SALVADOR GONZÁLEZ-GORDO, MARTA RODRÍGUEZ-RUIZ, MARÍA A. MUÑOZ-VARGAS, JOSÉ M. PALMA
BIOCELL, Vol.46, No.1, pp. 1-5, 2022, DOI:10.32604/biocell.2021.017300
Abstract Nitric oxide (NO) and hydrogen sulfide (H2S) are two molecules that share signaling properties in plant and
animal cells. NO and H2S originate two families of derived molecules designated reactive nitrogen and sulfur species (RNS
and RSS, respectively). These molecules are responsible for certain protein regulatory processes through posttranslational
modifications (PTMs), being the most remarkable S-nitrosation and persulfidation, which affect the thiol group of
cysteine residues. NO and H2S can also exert regulatory functions due to their interaction through the iron present in
proteins that contain heme groups or iron-sulfur clusters, as reported mainly in animal cells. However, the available… More >
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SEAN J. O’SULLIVAN1,2,*
BIOCELL, Vol.46, No.1, pp. 7-11, 2022, DOI:10.32604/biocell.2022.017680
Abstract The development of effective treatments for psychiatric disease has been disappointing in recent decades given the advancements in neuroscience. Moreover, rising rates of mental illness such as addiction and depression compel scientists and physicians to discover novel and creative solutions. One such approach that has proven effective is systems neuroscience: A focus on networks as opposed to mechanism. Further, investigation at the single-cell and circuit level is likely to be fruitful in such endeavors as this resolution describes the functional psychopathology that allows for intervention. More >
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SALONI THAKUR1, ADESH K. SAINI2,3, JOYDEEP DAS4, VIPIN SAINI3, PARIN BALHARA5, JAGPREET S. NANDA6, REENA V. SAINI2,3
BIOCELL, Vol.46, No.1, pp. 13-26, 2022, DOI:10.32604/biocell.2022.016953
（This article belongs to this Special Issue: Noncoding RNAs & Associated Human Diseases)
Abstract MicroRNA-153 (miR-153), belongs to a class of small non-coding RNA. It is a critical regulator of gene expression at the post-transcriptional level which interacts with the functional mRNA at 3’UTR region and suppresses the expression of the mRNA. More recently, it has become apparent that changes in the miR-153 expression lead to invasion, metastasis, angiogenesis and various types of tumor progression. This review summarizes the connection between dysregulation of miR-153 and various types of cancer progression. miR-153 regulates various signaling pathways to inhibit the proliferation and induce apoptosis in the cancer cell and also show synergistic activity with anticancer drugs.… More >
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ILGIZ GAREEV1, OZAL BEYLERLI1, CHUNLEI WANG2,3, ANDREI SOKHATSKII2,3, YANCHAO LIANG2,3, HUAN XIANG2,3, CHUNYANG LIU2,3, XUN XU2,3, YANG GUANG2,3
BIOCELL, Vol.46, No.1, pp. 27-35, 2022, DOI:10.32604/biocell.2022.016288
（This article belongs to this Special Issue: Noncoding RNAs & Associated Human Diseases)
Abstract Brain arteriovenous malformations (AVMs) are abnormal vessels that are prone to rupture, causing life-threatening intracerebral hemorrhage (ICH). Understanding the molecular basis of pathogenesis, timely diagnosis, and treatment of brain AVMs are some of the urgent problems in neurosurgery. MicroRNAs (miRNAs) are small endogenous RNAs that regulate gene-expression posttranscriptionally. MiRNAs are involved in almost all biological processes, including cell proliferation, apoptosis, and cell differentiation. Recent studies have shown that miRNAs can be involved in brain AVMs formation and rupture. There are also extracellular forms of miRNAs. Circulating miRNAs have been detected in the blood circulation and other body fluids. Owing to… More >
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MAURA BENEDETTI, MARIA ELISA GIULIANI, MARICA MEZZELANI, ALESSANDRO NARDI, LUCIA PITTURA, STEFANIA GORBI, FRANCESCO REGOLI
BIOCELL, Vol.46, No.1, pp. 37-49, 2022, DOI:10.32604/biocell.2022.017507
（This article belongs to this Special Issue: Oxidative Stress in Aquatic Organisms)
Abstract Oxidative stress is a critical condition derived from the imbalance between the generation of reactive oxygen species and the sophisticated network of antioxidant mechanisms. Several pollutants and environmental factors can affect this system through connected mechanisms, indirect relationships, and cascade effects from pre-transcriptional to catalytic level, by either enhancing intracellular ROS formation or impairing antioxidant defenses. This review summarizes the current knowledge on the pro-oxidant challenges from emerging environmental stressors threatening marine organisms, such as pharmaceuticals, microplastics and climate-related ocean changes. Emphasis will be placed on oxidative pathways, including signaling proteins and transcription factors involved in regulation of antioxidant responsiveness.… More >
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REVIEW
GASTÓN AMABLE#, EDUARDO MARTÍNEZ-LEÓN#, MARÍA E. PICCO, OSVALDO REY
BIOCELL, Vol.46, No.1, pp. 51-59, 2022, DOI:10.32604/biocell.2022.017565
Abstract Colorectal cancer (CRC) is one of the main causes of cancer-related mortality in the developed world despite recent developments in detection and treatment. Several epidemiological studies indicate that metformin, a widely prescribed antidiabetic drug, exerts a protective effect on different cancers including CRC. Furthermore, a recent double-blind placebo-controlled, randomized trial showed that metformin significantly decreased colorectal adenoma recurrence. Studies exploring the mechanism of action of metformin in cells derived from different types of cancers reported many effects including respiratory chain complex 1 inhibition, Akt phosphorylation inhibition, ATP depletion, PKA activation and Wnt signaling inhibition. However, many of these results were… More >
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REVIEW
MUBASHIR HUSSAIN1, ZEESHAN ALI1, BIN LIU2, JIANGUO DAI1, XIAOLONG LIU1, JUNCHEN ZHU1, YONGJUN TANG1
BIOCELL, Vol.46, No.1, pp. 61-74, 2022, DOI:10.32604/biocell.2022.016392
Abstract Dengue virus infections are increasing worldwide generally and in Asia, Central and South America and Africa, particularly. It poses a serious threat to the children population. The rapid and accurate diagnostic systems are essentially required due to lack of effective vaccine against dengue virus and the progressive spread of the dengue virus infection. The recent progress in developing micro- and nano-fabrication techniques has led to low cost and scale down the biomedical point-of-care devices. Starting from the conventional and modern available methods for the diagnosis of dengue infection, this review examines several emerging rapid and point-of-care diagnostic devices that hold… More >
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ARTICLE
AJIT C. DHADVE1,2, PRITHA RAY1,2
BIOCELL, Vol.46, No.1, pp. 75-86, 2022, DOI:10.32604/biocell.2022.016346
Abstract Progression, relapse, and therapy resistance are the most challenging features of cancer therapy that have been postulated to be driven by Cancer Stem Cell (CSC) population. This enigmatic subpopulation of cancer cells has therefore emerged as promising therapeutic candidate. We earlier reported enrichment of CSC-like side population (SP) with increasing resistance towards Cisplatin and Paclitaxel either alone or in combination in epithelial ovarian cancer (EOC) cells. This SP population is a small proportion of the total population of cancer cells characterised with high expression of drug transporters, a unique feature of stem cells and thereby can be isolated through their… More >
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YANYAN LI1, SHAHANAVAJ KHAN2,3,4, ANIS AHMAD CHAUDHARY5, HASSAN AHMED RUDAYNI5, ABDUL MALIK2, ASHWAG SHAMI6
BIOCELL, Vol.46, No.1, pp. 87-95, 2022, DOI:10.32604/biocell.2022.016509
Abstract Available reports have confirmed a link between bacterial infection and the progression of different types of cancers, including colon, lungs, and prostate cancer. Here we report the Chlamydia pneumonia proteins targeting in endoplasmic reticulum (ER) using in-silico approaches and their possible role in lung cancer etiology. We predicted 48 proteins that target human ER, which may be associated with protein folding and protein-protein interactions during infection. The results showed C. pneumoniae proteins targeting human ER and their implications in lung cancer growth. These targeted proteins may be involved in competitive interactions between host and bacterial proteins, which may change the… More >
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ARTICLE
MENGQIU CHENG1,2, WEI CAO2, GUODONG CAO1, XIN XU1,2,*, BO CHEN1,*
BIOCELL, Vol.46, No.1, pp. 97-109, 2022, DOI:10.32604/biocell.2021.015608
（This article belongs to this Special Issue: Computational Models in Non-Coding RNA and Human Disease)
Abstract Gastric cancer (GC) is one of the most common cancer worldwide. Although emerging evidence indicates that
autophagy-related long non-coding RNA (lncRNA) plays an important role in the progression of GC, the prognosis of
GC based on autophagy is still deficient. The Cancer Genome of Atlas stomach adenocarcinoma (TCGA-STAD) dataset
was downloaded and separated into a training set and a testing set randomly. Then, 24 autophagy-related lncRNAs were
found strongly associated with the survival of the TCGA-STAD dataset. 11 lncRNAs were selected to build the risk score
model through the least absolute shrinkage and selection operator (LASSO) regression. Every patient got… More >
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ARTICLE
JIAYU ZHANG1,2,3,#, RUOYAN CAO1,2,3,#, JIANMIN PENG1,2,3, QINCHAO HU1,2,3, JUAN XIA1,2,3,*, BIN CHENG1,2,3,*
BIOCELL, Vol.46, No.1, pp. 111-125, 2022, DOI:10.32604/biocell.2022.016612
Abstract Metabolic reprogramming and immunologic suppression are two critical characteristics promoting the progression of head and neck squamous cell carcinoma (HNSCC). The integrative analysis of all the metabolism-related genes (MRGs) in HNSCC is lacking and the interaction between the metabolism and the immune characteristics also requires more exploration to uncover the potential mechanisms. Therefore, this study was designed to establish a prognostic signature based on all the MRGs in HNSCC. Genes of HNSCC samples were available from the TCGA and GEO databases while the MRGs were retrieved from a previous study. Ultimately 4 prognostic MRGs were selected to construct a model… More >
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ARTICLE
AASTHA MITTAL1, NEELAM MAHALA1, KOWTHAVARAPU VENKATA KRISHNA2, UMA S. DUBEY1,*, SUNIL KUMAR DUBEY2,3,*
BIOCELL, Vol.46, No.1, pp. 127-136, 2022, DOI:10.32604/biocell.2021.015932
Abstract Sorafenib, a multikinase inhibitor used for the treatment of hepatocellular carcinoma, is limited by its low oral
bioavailability. To overcome this drawback, we have developed novel camel milk casein-derived nanoparticles as a drug
delivery system. Camel milk casein is not only biocompatible on oral administration but is actually a dietary protein of
pharmaceutical relevance. Casein is used because of its amphiphilic nature, self-assembling property, ability to show
sustained release, and capability of encapsulating both hydrophilic and hydrophobic drugs. In this study, camel milk
casein nanoparticles loaded with sorafenib were developed and characterized. Characterization of casein nanoparticles
was done by dynamic… More >
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ARTICLE
JIANRONG YANG1,#, WAN CHEN2,#, XING ZHOU3,#, YAOXUAN LI4,#, ZHIHUANG NONG5, LIYUAN ZHOU4, XUAN WEI4, XIAORONG PAN6, CHUNXIA CHEN7, WENSHENG LU3
BIOCELL, Vol.46, No.1, pp. 137-148, 2022, DOI:10.32604/biocell.2022.016807
（This article belongs to this Special Issue: Cellular Biomechanics in Health and Diseases)
Abstract In this study, we investigated the protective effect of hyperbaric oxygen (HBO) on PC12 and H9C2 cell damage caused by oxygen-glucose deprivation/reperfusion and its possible mechanism. PC12 and H9C2 cell oxygen-glucose deprivation/reperfusion model were established. Cells were divided into a control group, model group, hyperbaric air (HBA) group and HBO group. The cell viability was detected by the CCK8 assay. Hoechst 33342 and PI staining assays and mitochondrial membrane potential (MMP) assays were used to detect cell apoptosis. The ultrastructure of cells, including autophagosomes, lysosomes, and apoptosis, were examined using a transmission electron microscope. The expression of autophagy-related proteins was… More >
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ARTICLE
SICONG WANG1, RUIJIN LIU2, QIUYUAN HAN2, KAIJIANG YU3,*
BIOCELL, Vol.46, No.1, pp. 149-158, 2022, DOI:10.32604/biocell.2021.013027
Abstract Acute kidney injury (AKI), commonly occurring as complications of sepsis, cardiac surgery, and liver or kidney
transplantation, is a critical care syndrome. It is well known that lipopolysaccharide (LPS) shock is a common triggering
factor for AKI. This study is aimed to examine the effect of flavonoid compound hispidulin on LPS-induced AKI. For
this, renal tubular epithelial cell HK-2 was treated with LPS to establish an in vitro model of AKI. The effect of
hispidulin on HK-2 cell viability was examined using CCK-8 assay. Cell apoptosis was determined by TUNEL and flow
cytometry. Apoptosis marker proteins were determined by using… More >
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ARTICLE
QIANSHAN TAO#, QING ZHANG#, HUIPING WANG, HAO XIAO, MEI ZHOU, LINLIN LIU, HUI QIN, JIYU WANG, FURUN AN, ZHIMIN ZHAI*, YI DONG*
BIOCELL, Vol.46, No.1, pp. 159-169, 2022, DOI:10.32604/biocell.2021.014139
Abstract Acute myeloid leukemia (AML) is regarded as a stem cell disease. However, no one unique marker is expressed
on leukemia stem cells (LSC) but not on leukemic blasts nor normal hematopoietic stem cells (HSC). CD34+
CD38- with
or without CD123 or CD44 subpopulations are immunophenotypically defined as putative LSC fractions in AML.
Nevertheless, markers that can be effectively and simply held responsible for the intrinsical heterogeneity of LSC is
still unclear. In the present study, we examined the frequency of three different LSC subtypes (CD34+
CD38-,
CD34+
CD38-
CD123+
, CD34+
CD38-
CD44+
) in AML at diagnosis. We then… More >
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ARTICLE
RONGXUE WEI1, CHUNCHUN HAN1,*, FENGJIANG YE1, SHOUHAI WEI2, FANG HE1, HEHE LIU1, LIANG LI1, HONGYONG XU1, SHENQIANG HU1, XIANYIN ZENG2
BIOCELL, Vol.46, No.1, pp. 171-183, 2022, DOI:10.32604/biocell.2022.015409
Abstract In order to explore the role of forkhead box protein O1 (FoxO1) in the lipid metabolism and cell proliferation, goose primary hepatocytes were isolated and incubated with insulin or PI3K-Akt-mTOR pathway dual inhibitor NVP-BEZ235, and then transfected with FoxO1 interference plasmid. The related parameters of lipid metabolism and cell proliferation were measured. The results firstly showed that FoxO1 interference increased the intracellular TG and lipids concentration (P < 0.05); and increased the proliferative index (PI), cell DNA synthesis, protein expression of Cyclin D1 in goose primary hepatocytes (P < 0.05). Secondly, the co-treatment of insulin and FoxO1 interference increased the… More >
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ARTICLE
JIANBO LU1,2,#,*, XIAOHAN SUN3,#, XU MA1,2,*
BIOCELL, Vol.46, No.1, pp. 185-193, 2022, DOI:10.32604/biocell.2021.015301
Abstract The concentration of cell-free fetal DNA fragments should be detected before noninvasive prenatal testing
(NIPT). The fetal DNA molecules have significant clinical potential in determining the overall performance of NIPT
and clinical interpretation. It is important to measure fetal DNA fraction before NIPT. However, there is still little
research on how to calculate the concentration of female fetuses. Two estimation approaches were proposed to
calculate fetal DNA fraction, including the fragments size-based approach, aneuploid-based approach, which are all
approaches based on chromosome segments. Based on high-throughput sequencing data, two approaches to calculate
the DNA fraction of male fetuses were tested… More >
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ARTICLE
JUAN ZHANG2, JUN HUANG3, YAYUAN TANG2, XIUZHEN LONG1
BIOCELL, Vol.46, No.1, pp. 195-205, 2022, DOI:10.32604/biocell.2022.016563
（This article belongs to this Special Issue: Reproductive Health and Embryonic Development)
Abstract Age-related declines in fertilization success have been reported for a wide range of species. The fertilization of parasitic wasps is closely related to egg production and sperm storage. Aenasius bambawalei (Hymenoptera: Encyridae) is a key parasitic wasp of the important invasive mealybug Phenacoccus solenopsis (Hemiptera: Pseudococcidae). The female offspring ratio of this parasitic wasp was declined with parental age in mass rearing under laboratory conditions. To investigate the molecular mechanisms involved in the reproduction of A. bambawalei, an extensive analysis of the impact of age on transcriptome profile of mated ovaries of this wasp was performed by comparing the gene… More >
Open Access
ARTICLE
PENG YANG1,*, ZHIYING ZOU1, XULING GAO2
BIOCELL, Vol.46, No.1, pp. 207-218, 2022, DOI:10.32604/biocell.2021.014728
Abstract Recent studies have shown that the microtubule disrupting protein Stathmin 1 (STMN1) is differentially
expressed in AML patients and healthy control. The aim of this study was to explore the effects and molecular
mechanism of STMN1 in AML. Here, the expression of STMN1 in peripheral blood cells (PBMCs) and bone marrow
of AML patients and healthy volunteers was detected by RT-PCR and Western blot. STMN1 expression was regulated
by transfected with STMN1 overexpressed plasmid or shRNA in two human leukemia cell lines K562 and HL60. Cell
proliferation was examined by CCK8 and Edu staining. Annexin V and TUNEL assays were… More >
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ARTICLE
ALI H. ABU ALMAATY1, BASMA M. HENDAM2, FAYEZ ALTHOBAITI3, EMAN FAYAD3,*, YASMIN M. ABD EL-AZIZ1
BIOCELL, Vol.46, No.1, pp. 219-234, 2022, DOI:10.32604/biocell.2022.017623
（This article belongs to this Special Issue: Mesenchymal Stem Cells, Secretome and Biomaterials: Regenerative Medicine Application)
Abstract The hepatotoxic effect of potassium bromide (KBr) on rat liver tissues were determined, as well as the potential protective effect of Tegillaraca granosa (T. granosa) flesh body extract. Twenty adult male albino rats were equally distributed into four groups; Group (I) treated with physiological saline (control group), Group (II) was orally gavaged by 200 mg/kg of T. granosa body extract day after day, Group (III) was intoxicated by KBr (150 mg/kg bwt day after day orally) and finally, Group (IV) was given a combination of T. granosa flesh body extract plus KBr with similar doses in the second and third… More >
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ARTICLE
LUPING YANG1,#, YIJING JIANG2,#, XIAOQIAN YE3,#, YONGMEI YOU2, LING LIN2, JING LIAN2, JUAN LI1, SHANLI YANG2, XIEHUA XUE2
BIOCELL, Vol.46, No.1, pp. 235-245, 2022, DOI:10.32604/biocell.2022.014997
Abstract ATP depletion is one of the pathological bases in cerebral ischemia. Electro-acupuncture (EA) is widely used in clinical practice for ischemia. However, the mechanism of EA remains unclear. The purpose of this study was to investigate whether EA could activate the AMPK/PGC-1α/TFAM signaling pathway and, consequently, increase the preservation of ATP in rats with ischemia. In this study, 48 rats were randomly divided into four groups as a sham-operation control group (sham group), a middle cerebral artery occlusion group (MCAO group), an EA group, and an EA group blocked by the AMPK inhibitor compound C (EA + CC group) (N… More >
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ARTICLE
JELAN MOFEED1,2, MOHAMED DEYAB3, ABDELNASER MOHAMED3, MAHMOUD MOUSTAFA4,5, SALLY NEGM6,7, EMAD EL-BILAWY1
BIOCELL, Vol.46, No.1, pp. 247-261, 2022, DOI:10.32604/biocell.2022.015966
Abstract
Microbial infections cause complicated health influences along with bad economic impacts. In the present investigation, three dominant seaweeds namely, Amphiroa anceps, Corallina officinalis and Sargassum filipendula were collected from different Egyptian sites at the Red Sea and Mediterranean Sea during autumn 2019. Organic extracts of the three algae were screened for their antibacterial activity against three pathogenic bacteria Salmonella typhiimurium, Staphylococcus aureus and Escherichia coli, in addition to in vitro antiviral activity against Rotavirus (RV), and Coxsackie virus B3 (CVB3) that cause severe diseases in human. Organic extract of A. anceps, C. officinalis and S. filipendula inhibit E. coli cells… More >
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ARTICLE
LINGJIAO FAN1, DAN SONG1, YINGWEI KHOO2, MENGMENG WU1, TENGFEI XU1, XIAOLI ZHAO1, HONGQING WANG1
BIOCELL, Vol.46, No.1, pp. 263-273, 2022, DOI:10.32604/biocell.2022.016306
Abstract
Strawberry mottle virus (SMoV) and strawberry vein banding virus (SVBV) cause diseases on strawberry plants, but the effect of coinfection of SMoV and SVBV on the growth, development, and defense system of strawberry (Fragaria × ananassa Duchesne) remains unknown. We investigated the effect of SMoV and SVBV co-infection on strawberry cultivar ‘Benihope’. The results showed that stem diameter, leaf size, leaf number, relative chlorophyll content, total chlorophyll content, photosynthetic parameters, and stomatal aperture of SMoV and SVBV co-infected strawberry (VIS) plants were in a weaker level than uninfected control plants, indicating that viruses inhibited the growth and photosynthesis of strawberry… More >
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ARTICLE
KHESLLER PATRÍCIA OLAZIA1,2, JULIANA SOUZA DA SILVA1, GUILHERME SIRIMARCO DE SOUZA TONELLI1, SÔNIA NAIR BÁO1,*
BIOCELL, Vol.46, No.1, pp. 275-283, 2022, DOI:10.32604/biocell.2022.016603
Abstract In this study, the sperm ultrastructure of three species of Idarnes genus was investigated using light and transmission electron microscopy. Spermatozoon morphology of the three species was similar to that of most Chalcidoidea, with helicoidally twisted nucleus and flagellum. The head region consists of an acrosome and a nucleus; the nucleus-flagellum transition region characterized by the presence of mitochondrial derivatives and the centriolar adjunct; a flagellum region, which includes the axoneme with microtubular arrangement 9 + 9 + 2 and two mitochondrial derivatives. However, the sperm of these three species exhibit features that discriminate one species from each other: (1)… More >
Open Access
ARTICLE
JIANFEI GAO1, KANGNING XIONG2,*, WEIJIE LI1, WEI ZHOU3
BIOCELL, Vol.46, No.1, pp. 285-296, 2022, DOI:10.32604/biocell.2021.016253
Abstract Kadsura coccinea (Lem.) is a woody wine plant with a peculiar fruit enriched in important health-promoting
compounds. The non-editable part of the fruit, i.e., the seed and peel, represents more than 60% of the fruit and is
considered a biowaste. This significantly restricts the development of the K. coccinea fruit industry. Clarifying the
metabolic components of the different fruit parts can help to improve the utilization rate and valorization of
K. coccinea. Herein, we evaluated K. coccinea fruit peel, pulp, and seed using widely-targeted metabolomics and
quantified a set of 736 bioactive compounds from 11 major metabolite classes. The most… More >
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