Guest Editors
Prof. Dr. Oriana Trubiani, Department of Innovative Technologies in Medicine & Dentistry, University “G. d’Annunzio”, Chieti-Pescara, 66100 Chieti, Italy; oriana.trubiani@unich.it
Dr. Francesca Diomede, Department of Innovative Technologies in Medicine & Dentistry, University “G. d’Annunzio”, Chieti-Pescara, 66100 Chieti, Italy; francesca.diomede@unich.it
Dr. Jacopo Pizzicannella, ASL02 Lanciano-Vasto-Chieti, “Ss. Annunziata” Hospital, 66100 Chieti, Italy; jacopo.pizzicannella@unich.it
Summary
Mesenchymal Stem Cells (MSCs) are adult stem cells which can be isolated from human source. Human MSCs (hMSCs) are the non-haematopoietic, multipotent stem cells with the capacity to differentiate into mesodermal, endodermal and ectodermal lineages. MSCs express cell surface markers like cluster of differentiation (CD) 29, CD44, CD73, CD90, CD105 and lack the expression of CD14, CD34, CD45 and HLA (human leucocyte antigen)-DR. For the first time, hMSCs, were described in the bone marrow and till now they have been isolated from various sources, as adipose tissue, amniotic fluid, endometrium, dental tissues, and umbilical cord. hMSCs are able to maintain their stemness properties and features for long-term in vitro passage. MSCs show immunomodulatory features, release cytokines and immune-receptors which regulate the microenvironment in the host tissue.
Manipulation of stem cells or stem cells-derived secretome has emerged as a novel alternative therapeutic option for several diseases or in regenerative medicine in order to improve scaffold effects. Stem cells secretome exert its therapeutic effects mainly through the paracrine signaling of exosomes/microvesicles secreted into cell culture conditioned medium. These are small membrane vesicles released by a variety of cell types, containing functional cytokines and other proteins, lipids and nucleic acids, such as mRNA and microRNA. The soluble bioactive molecules present in the conditioned medium directly activate the target cells, suppress pro-inflammatory responses, modulate the immune system, inhibit apoptosis and fibrosis, and stimulate tissue-intrinsic progenitor cells differentiation. The stem cells secretome could provide a novel cell-free regenerative therapeutical approach in various diseases and in regenerative medicine.
Then, to evaluate the aptitude of secretome derived from stem cells in terms of tissue regeneration we invite authors to contribute with original research articles, reviews and opinion letters focused on the use of secretome-derived stem cells for future clinical applications.
Potential topics include but are not limited to the following:
•Mesenchymal stem cells models for drug personalized therapy;
•Functionalized biomaterial with mesenchymal stem cells;
•Functionalized biomaterial with secretome;
•Mesenchymal stem cells secretome;
•Mesenchymal stem cells models of systemic and genetic diseases.
Keywords
Mesenchymal Stem Cells, Secretome, Extracellular Vesicles, Exosomes, Biomaterials, Regenerative Medicine, Tissue Engineering.
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