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Exosomes from adipose tissue-derived stem/stromal cells: A key to future regenerative medicine

JÉRÔME LALOZE^1,2, ALEXIS DESMOULIÈRE^1,*
1 University of Limoges, Neuropathies and Therapeutic Innovations (UR 20218), Faculties of Medicine and Pharmacy, Limoges, F-87000, France
2 Department of Maxillo-Facial and Reconstructive Surgery and Stomatology, University Hospital Dupuytren, Limoges, F-87000, France
* Corresponding Author: ALEXIS DESMOULIÈRE. Email:
(This article belongs to this Special Issue: Mesenchymal Stem Cells, Secretome and Biomaterials: Regenerative Medicine Application)

BIOCELL 2022, 46(12), 2701-2704. https://doi.org/10.32604/biocell.2022.022229

Received 28 February 2022; Accepted 20 May 2022; Issue published 10 August 2022

Abstract

Advances in regenerative medicine correlate strongly with progress in the use of adipose tissue-derived mesenchymal stem/stromal cells. The range of therapeutic indications has also expanded over recent years. Numerous recent studies have highlighted the primary importance of paracrine secretion by these cells. Though it is interesting to compare the different types of such secretions, we believe that exosomes (extra-cellular vesicles possessing the same properties as their source cells) will likely be the main key in tomorrow’s cell therapy. Exosomes also have many advantages compared to the direct use of cells, making these particles a major target in fundamental and translational research.

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Keywords

Adipose-derived mesenchymal stem/stromal cell; Exosome; Regenerative medicine; Secretome

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