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Therapeutic mechanisms and routes of delivery of mesenchymal stem cells in veterinary medicine: A point of view

AMANDA BARACHO TRINDADE HILL1,2,*, JONATHAN EDWIN BARACHO TRINDADE HILL2
1 Centro Universitário Max Planck, Indaiatuba, Brazil
2 CellTech-Stem Cell Technologies, Campinas, Brazil
* Address correspondence to: Amanda Baracho Trindade Hill,
(This article belongs to this Special Issue: Mesenchymal Stem Cells, Secretome and Biomaterials: Regenerative Medicine Application)

BIOCELL 2022, 46(5), 1173-1176. https://doi.org/10.32604/biocell.2022.018637

Received 07 August 2021; Accepted 06 October 2021; Issue published 06 January 2022

Abstract

Mesenchymal stem cells (MSCs) represent an important tool in veterinary regenerative medicine due to their ability to home to injury sites and secrete molecules that regulate niches into regenerative microenvironments. Successful cell therapy depends on many factors, including choice of administration route and application of understanding of cell potency and their therapeutic mechanisms. In this point of view, the authors leverage the tumultuous history of the field to demonstrate the need for clinicians to continually update themselves as new discoveries are made in order to avoid misalignments in the future, especially regarding administration routes and dose frequency, as well as to explore recent insights into MSC plasticity, therapeutic mechanisms, and cell delivery systems.

Keywords

Cell therapy; Application; Injection; Pharmacodynamics; Pharmacokinetics

Cite This Article

BARACHO, A., EDWIN, J. (2022). Therapeutic mechanisms and routes of delivery of mesenchymal stem cells in veterinary medicine: A point of view. BIOCELL, 46(5), 1173–1176.



This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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