Home / Journals / BIOCELL / Vol.43, No.1, 2019
Table of Content
  • Open Access

    REVIEW

    Coxiella burnetii: living inside the host cell

    Jesus Sebastian DISTEL1, Walter BERON1, Rodolfo Matias ORTIZ FLORES1,2
    BIOCELL, Vol.43, No.1, pp. 1-6, 2019, DOI:10.32604/biocell.2019.07021
    Abstract Coxiella burnetii is an obligate intracellular pathogen and the causative agent of Q fever. In this brief review, we describe how recently described mechanisms help our understanding of C. burnetii invasion and its survival in the host cell by the formation of a replicative niche: the Coxiella-containing vacuole. We describe the actin-associated proteins involved in the internalization of C. burnetii, and we discuss the contribution of diverse degradation pathways of the cell during the formation and stabilization of the Coxiella-containing vacuole. More >

  • Open Access

    ARTICLE

    Meta-analysis evaluation of the treatment of neonatal hypoxic– ischemic encephalopathy with ganglioside

    Wen LI, Junli YANG, Dong ZHOU, Jinghui ZHANG, Qingcui ZHUO
    BIOCELL, Vol.43, No.1, pp. 7-12, 2019, DOI:10.32604/biocell.2019.04763
    Abstract The efficacy and safety of ganglioside in the treatment of neonates who suffer from hypoxic–ischemic encephalopathy (HIE) needs to be fully evaluated. We searched the following databases: PubMed, ScienceDirect, LISTA, CNKI, Chinese biomedical literature database and Wanfang digital journals of full-text database to determine the inclusion and exclusion criteria of papers and a total of 12 papers were included after quality evaluation. Then we conducted the meta-analysis with RevMan5.0 software. The results showed that compared with the control group, the abnormal rate declined in the ganglioside-treated group (relative risk (RR)=0.27, 95% confidence interval (CI)= 0.05– 1.96). NBNA records of the… More >

  • Open Access

    ARTICLE

    Trypanosoma rangeli: growth in mammalian cells in vitro and action of a repositioned drug (17-AAG) and a natural extract (Artemisia sp. essential oil)

    Ana Laura CIMADOR1,#, Emeli Luciana GALANTE1,#, Lucila Ibel MUÑOZ1,#, Patricia Silvia ROMANO2,3, Antonella Denisse LOSINNO1,2, María Cristina VANRELL1,2,3
    BIOCELL, Vol.43, No.1, pp. 13-20, 2019, DOI:10.32604/biocell.2019.07018
    Abstract Trypanosoma rangeli and T. cruzi are both parasitic unicellular species that infect humans. Unlike T. cruzi, the causative agent of Chagas disease, T. rangeli is an infective and non-pathogenic parasite for humans, but pathogenic for vectors from the Rhodnius genus. Because both species can coexist in different hosts and overlap their infective cycles but very little is known about the infection of T. rangeli in mammalian cells, we decided to characterize both the development of this parasite in cell culture and the effect of therapeutic agents with potential trypanocidal action on it. We found that T. rangeli exhibits a cycle… More >

  • Open Access

    ARTICLE

    Mesenchymal stem cells transplantation attenuates experimentally induced brain injury after neonatal hypoxia by different two routes of administrations

    Nesrine EBRAHIM1, Eman EHSAN2, Eman Abd EL GHANY2, Dina SABRY3, Ashraf SHAMAA4
    BIOCELL, Vol.43, No.1, pp. 21-28, 2019, DOI:10.32604/biocell.2019.06111
    Abstract The neonatal hypoxic–ischemic encephalopathy (HIE) is an important cause of neurological morbidity and mortality in neonates. Cell therapy is considered a promising method for treating severe neurological disorders such as this one. Stem cells have the capacity for self-renewal and differentiation into certain cell lineages. The present study was aimed to find out the most beneficial route of bone marrow-derived mesenchymal stem cells (BMSCs) administration for the attenuation of experimentally induced HIE in neonatal rats. Sixty neonatal rats were divided randomly into four groups. Group 1: control group. Group 2: rats were exposed to bilateral ligation of cephalic arteries. Group… More >

  • Open Access

    ARTICLE

    Design and development of a dual-flow bioreactor mimicking intestinal peristalsis and permeability in epithelial tissue barriers for drug transport assessment

    Odin RAMÍREZ-FERNÁNDEZ1,2,3,*, Ludovika CACOPARDO1, Benjamín LEON-MANCILLA2, Joana COSTA1
    BIOCELL, Vol.43, No.1, pp. 29-36, 2019, DOI:10.32604/biocell.2019.04790
    Abstract We present a bioreactor system which combines a semi permeable membrane that simulates the osmotic nutrients interchange in the small intestine circulation and rhythmic peristaltic movement. This custom-designed presents a semipermeable membrane bioreactor, with peristaltic flow and compression variation that allows adjustment of luminal flow rate. In addition, this system is also capable of achieving the drug distribution in the small intestine model from the apical compartment to the basal compartment by the semipermeable channel. This dynamic bioreactor can mimic the human small intestine with increased accuracy to overcome many of the limitations and accuracy with the previously described in… More >

  • Open Access

    ARTICLE

    Alteration of ADP-ribosylation in aging rat brain astrocytes

    Manoochehr MESSRIPOUR1, Azadeh MESRIPOUR2
    BIOCELL, Vol.43, No.1, pp. 37-40, 2019, DOI:10.32604/biocell.2019.05865
    Abstract DNA damage and the enzyme poly (ADP-ribose) polymerase (PARP) associated with the pathogenesis of numerous age-related neurodegenerative disorders. Astrocytes play crucial roles in both support metabolic functions and cell viability of the brain. PARP regulates DNA damage and repair in the brain cells. In this study PARP activity and DNA strand break were investigated in the astrocytes isolated from young and aged rat brain. Three and 30-month-old rats were killed by decapitation and brains were removed onto an ice cooled glass plate. Astrocytes were isolated by sucrose density gradient centrifugation and glutamine synthetase (GS) served as a marker of the… More >

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