Home / Journals / BIOCELL / Vol.42, No.2, 2018
Table of Content
  • Open Access

    ARTICLE

    Diabetic nephropathy, autophagy and proximal tubule protein endocytic transport: A potentially harmful relationship

    Maximiliano GIRAUD-BILLOUD1,2,*, Claudio M. FADER1,3, Rocío AGÜERO2, Fernando EZQUER4, Marcelo EZQUER4
    BIOCELL, Vol.42, No.2, pp. 35-40, 2018, DOI:10.32604/biocell.2018.07010
    Abstract Diabetic nephropathy (DN) is the most frequent cause of chronic renal failure. Until now, the pathophysiological mechanisms that determine its development and progression have not yet been elucidated. In the present study, we evaluate the role of autophagy at early stages of DN, induced in type 2 diabetes mellitus (T2DM) mouse, and its association with proximal tubule membrane endocytic receptors, megalin and cubilin. In T2DM animals we observed a tubule-interstitial injury with significantly increased levels of urinary GGT and ALP, but an absence of tubulointerstitial fibrosis. Kidney proximal tubule cells of T2DM animals showed autophagic vesicles larger than those observed… More >

  • Open Access

    REVIEW

    Microglia-precursor cell interactions in health and in pathology

    Estela M. MUÑOZ
    BIOCELL, Vol.42, No.2, pp. 41-46, 2018, DOI:10.32604/biocell.2018.07011
    Abstract Until recently, microglia were mainly known as the resident phagocytes of the brain, i.e. the ‘immunological warriors’ of the brain. However, extensive knowledge is being accumulated about the functions of microglia beyond immunity. Nowadays, it is well accepted that microglial cells are highly dynamic and responsive, and that they intervene in a dual manner in many developmental processes that shape the central nervous system, including neurogenesis, gliogenesis, spatial patterning, synaptic formation and elimination, and neural circuit establishment and maturation. The differentiation and the pool of precursor cells were also shown to be under microglia regulation via bidirectional communication. In this… More >

  • Open Access

    ARTICLE

    Characterization of multidrug-resistant Klebsiella pneumoniae isolated from the Chinese cobra Naja atra in a Beijing suburb

    Haifeng WANG1, 2, 3 , Hongxuan HE2
    BIOCELL, Vol.42, No.2, pp. 47-54, 2018, DOI:10.32604/biocell.2018.07006
    Abstract The emergence and spread of antibiotic resistance genes among Bacteria are a serious threat to global health. Their occurrence in animals which are in contact with humans is also important. The Chinese cobra (Naja atra, Elapidae), though a highly venomous species, is appreciated as food and as a source of materials used in traditional Chinese medicine. We are here reporting the isolation of multidrug-resistant Klebsiella pneumoniae (Enterobacteriaceae) from the lung of Naja atra, obtained from a snake farm in a Beijing suburb. Our study analyzed, using gene sequencing, the occurrence of antibiotic resistance genes (ARGs) in three K. pneumoniaeMore >

  • Open Access

    ARTICLE

    Associations between CD133, CK19 and G2/M in cirrhotic HCV (genotype-4) patients with or without accompanying tumor

    Hoda M. EL-EMSHATY1, Entsar A. SAAD2, Mona S. GOUIDA3, Zahraa R. ELSHAHAWY1,2
    BIOCELL, Vol.42, No.2, pp. 55-60, 2018, DOI:10.32604/biocell.2018.07009
    Abstract Hepatitis C virus (HCV)-cirrhotic patients have the highest threat of developing hepatocellular carcinoma (HCC) and may be at risk of extra hepatic cancer. The present study was designed to investigate CD133 and CK19 in HCV (genotype-4)-cirrhotic patients with/without HCC or extra hepatic cancer, to assess the degree of their correlation with cell cycle abnormalities and finally to assess the role of their combination as diagnostic tool for discrimination of cirrhotic patients with HCC from those with extra hepatic cancer. The study included 77 HCV-cirrhotic patients and 20 healthy non-disease control group. Patients were categorized histo-pathologically into: 24 have only liver… More >

  • Open Access

    ARTICLE

    Effects of precipitation changes on the dynamics of sparse elm woodland in Northeastern China

    Yi TANG1,*, Carlos Alberto BUSSO2
    BIOCELL, Vol.42, No.2, pp. 61-66, 2018, DOI:10.32604/biocell.2018.07015
    Abstract Elm (Ulmus pumila L.) is the dominant tree species in the sparse elm woodland, the original vegetation in the Horqin Sandy Land. The effects of changes in precipitation on U. pumila trees have not been fully studied. We determined a dynamic model by considering the five stages in the U. pumila life cycle, i.e. seed, seedling, and juvenile, mature and over-mature tree stages. The effects of changes in precipitation on population density and age structure were then evaluated. Population density, after averaging all study developmental morphology stages, ranged from 16.67 individuals/m2 to 25.01 individuals/m2 under a mean annual precipitation (MAP)… More >

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