Open Access
ARTICLE
MIN LIU1,*, XIA LI2, JUN LIU1, YU LIU1
BIOCELL, DOI:10.32604/biocell.2024.053227
（This article belongs to the Special Issue: Cell Death and Inflammation in Signaling and Diseases)
Abstract Background: Alveolar macrophage pyroptosis exacerbates inflammatory lung diseases, and tanshinone IIA is known for its anti-inflammatory properties. Thus, understanding how tanshinone IIA affects alveolar macrophage pyroptosis is essential. Methods: NR8383 cells were exposed to lipopolysaccharide (LPS) and adenosine triphosphate (ATP). We assessed cell viability, pyroptosis, and the expression of triggering receptors expressed on myeloid cells 2 (TREM2), p-β-catenin, β-catenin, and pyroptosis-related factors. We also examined the interaction between tanshinone IIA and TREM2. Results: Co-stimulation with LPS and ATP significantly reduced NR8383 cell viability, increased pyroptosis, and upregulated pyroptosis-associated factors. Treatment with tanshinone IIA mitigated these effects.… More >
Open Access
ARTICLE
HYEON JU LEE1, CHANG SEOP LEE1, SI HOON KIM1, SOOKYUNG KIM1, JEONG MI KIM1, SUN-WHA IM1, YU-JIN JUNG2, SEUNG-PYO HONG3, HYUNJUNG LEE3, JONG-IL KIM3,4,5, JEONG A. HAN1,*
BIOCELL, DOI:10.32604/biocell.2024.054538
Abstract Objective: Transformation from normal cells to malignant cells is the basis for tumorigenesis. While this cell transformation is known to result from aberrant activation or inactivation of associated genes, these genes have not yet been fully identified. In addition, DNAJs, proteins with a J domain, are known to be molecular co-chaperones, but their cellular functions remain largely unexplored. In this context, we here identified DNAJA4, DNAJB11, and DNAJC10 as pro-transforming genes and elucidated their action mechanisms. Methods: Senescence-associated (SA)-β-galactosidase staining and western blotting were used to analyze cellular senescence and protein expression. Soft agar assay was used… More >
Open Access
REVIEW
VINíCIUS AUGUSTO SIMãO1, LUIZ GUSTAVO DE ALMEIDA CHUFFA1, LEóN FERDER2, FELIPE INSERRA2, WALTER MANUCHA3,4,*
BIOCELL, DOI:10.32604/biocell.2024.053478
（This article belongs to the Special Issue: Gut Microbiota in Human Health: Exploring the Complex Interplay)
Abstract The interplay between mitochondria, epigenetics, and the microbiota is intricately linked to both health and disease. Within our cells, a complex molecular dance occurs, where these components intertwine in a mesmerizing ballet that plays a decisive role in our health. Mitochondria, beyond being energy powerhouses, modulate nuclear gene expression through messengers like reactive oxidative stress (ROS) and calcium. Epigenetics, acting as the molecular conductor, regulates the expression of both nuclear and mitochondrial genes through modifications like DNA methylation. The intestinal microbiota itself produces short-chain fatty acids (SCFAs) that influence mitochondrial activity. SCFA-induced epigenetic modifications, like… More >
Open Access
REVIEW
XUELING HE, LINLU JIN, YIXUE QIN, JIAN ZHONG, ZHI OUYANG, YE ZENG*
BIOCELL, DOI:10.32604/biocell.2024.055410
Abstract Cellular biomechanical features contributed to the occurrence and development of various physiological and pathological phenomena. Micropillar arrays have emerged as an important tool for both the assessment and manipulation of cellular biomechanical characteristics. This comprehensive review provides an in-depth understanding of the fabrication methodologies of micropillar arrays and their applications in deciphering and fine-tuning cellular biomechanical properties and the innovative experimental platforms including organ-on-a-chip and organoids-on-a-chip. This review provides novel insights into the potential of micropillar technology, poised to update the landscape of stem cell research and tissue engineering. More >
Open Access
REVIEW
HAO WU#, NA HUO#, SITUO WANG, ZIWEI LIU, YI JIANG*, QUAN SHI*
BIOCELL, DOI:10.32604/biocell.2024.054278
Abstract Stem cells have shown great application potential in wound repair, tissue regeneration, and disease treatment. Therefore, a full understanding of stem cells and their related regulatory mechanisms in disease treatment is conducive to improving the therapeutic effect of stem cells. However, thus far, there are still many unsolved mysteries in the field of stem cells due to technical limitations, which hinder the in-depth exploration of stem cells and their wide clinical application. Single-cell sequencing (SCS) has provided very powerful and unbiased insights into cell gene expression profiles at the single-cell level, bringing exciting results to More >
Open Access
REVIEW
QINGYANG ZHANG, SHUXIAN HUANG, DAN WENG*
BIOCELL, DOI:10.32604/biocell.2024.053794
（This article belongs to the Special Issue: Neural Stem Cells in Health and Disease: Mechanisms and Applications)
Abstract Huntington’s disease (HD) is a debilitating neurodegenerative disorder caused by an abnormal expansion of CAG repeats (Cytosine, Adenine, Guanine) in the huntingtin gene (HTT). This mutation leads to the production of a mutant huntingtin protein, resulting in neuronal dysfunction and cell death. Current treatments primarily focus on symptomatic relief and do not address the underlying genetic cause. This review explores spliceosome-mediated RNA trans-splicing (SMaRT) therapy as an innovative and potential approach for HD treatment. SMaRT leverages the cell’s natural splicing machinery to correct mutant mRNA, thereby reducing toxic protein levels while restoring functional protein production. We More >
Open Access
REVIEW
MOHAMMAD-SADEGH LOTFI, FATEMEH B. RASSOULI*
BIOCELL, DOI:10.32604/biocell.2024.053597
（This article belongs to the Special Issue: Perspectives on Stem Cells and Regenerative Medicine)
Abstract Parkinson’s disease (PD) is one of the fastest-growing neurodegenerative disorders worldwide. So far, PD treatments only offer little clinical relief and cannot reverse or stop the disease progression. Stem cell (SC) therapy is a rapidly evolving technology that holds significant promise for enhancing current therapeutic approaches. Adipose-derived mesenchymal SCs (AD-MSCs) have many features such as easy harvest with minimal invasive techniques, high plasticity, non-immunogenicity, and no ethical issues, which have made them suitable choices for clinical applications in regenerative research. AD-MSCs are ideal tools to treat PD, as they have the potential to differentiate into… More >
Open Access
REVIEW
JIAJUN HUANG1,#, WEI WANG1,#, WENTONG LIN2, HENGSEN CAI3, ZHIHAN ZHU1, WAQAS AHMED4, QIANKUN ZHANG1, JIALE LIU1, YIFAN ZHANG1, RONG LI1, ZHINUO LI1, AHSAN ALI KHAN5, DENG LU3, YONG HU6, LUKUI CHEN1,*
BIOCELL, DOI:10.32604/biocell.2024.053148
（This article belongs to the Special Issue: Exosomes in Cell Communication and Disease: From Biomarkers to Therapeutic Targets)
Abstract Degeneration and death of nerve cells are inevitable with the occurrence and progression of nervous system disorders. Researchers transplanted neural stem cells into relevant areas, trying to solve the difficulty of neural cell loss by differentiating neural stem cells into various nerve cells. In recent years, however, studies have shown that transplanted neural stem cells help neural tissues regenerate and return to normal through paracrine action rather than just replacing cells. Exosomes are essential paracrine mediators, which can participate in cell communication through substance transmission. In this regard, this review mainly discusses the current research More >
Open Access
ARTICLE
YU TANG1, WENXIAO HU2,*, YAJUN PENG1, XIANGDONG LING2
BIOCELL, DOI:10.32604/biocell.2024.052692
Abstract Background: Podocyte injury is crucial in diabetic kidney disease (DKD) progression, and the mechanism
remains unclear. The previous studies indicated Diosgenin played a key role in inhibiting podocyte injury progression.
However, more research is needed to explore Diosgenin in inhibiting-molecular mechanisms in the process of
podocyte injury. Methods: The content of Diosgenin in HeShenwan was detected by High-Performance Liquid
Chromatography-mass spectrometry (HPLC-MS) method. The podocyte injury model was constructed by high
glucose (HG)-induced mpc5 cells. The Cell Counting Kit-8 (CCK-8) assay was utilized to evaluate the activity of
mpc5 cells. Pyroptosis in mpc5 cells was assessed… More >
Graphic Abstract
Open Access
REVIEW
ZEYIN LAI1, HANGYUAN ZHAO1, HONG DENG1,2,*
BIOCELL, DOI:10.32604/biocell.2024.053983
（This article belongs to the Special Issue: Extracellular Matrix in Development and Disease)
Abstract In the development of colorectal cancer (CRC), cancer-associated fibroblasts (CAFs) play a pivotal role in establishing tumor-permissive extracellular matrix structures, angiogenesis, and modulating the immune status of the tumor microenvironment (TME), thereby influencing tumor metastasis and resistance to radiotherapy and chemotherapy. The pleiotropic effects of CAFs in the TME may be attributed to the heterogeneous origin and high plasticity of their population. Given the specificity of CAFs, they provide a variety of potential target molecules for future CRC treatment, which may play an indispensable role in CRC therapeutic strategies. This review summarizes the origin of More >
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