Open Access
ARTICLE
ZIPENG LIN1,#, CHUXI TANG1,#, LE KANG2, GUANXI LAI1, SHIWEN LIU1, YIXIANG WU1, HUIQUN TIAN3,*, SONG LIU1,4,5,*
BIOCELL, DOI:10.32604/biocell.2023.030233
（This article belongs to this Special Issue: Frontiers in cancer: tumor microenvironment)
Abstract The multiple roles of the tumor necrosis factor (TNF)-α-inducible protein 8 (TNFAIP8), also named TIPE
family of proteins have been shown in tumor and inflammation progression and regulation of cellular autophagy and
apoptosis. In this review, we found that the TIPE family showed highly homologous sequences and conserved
functional domains, such as the death effector domain (DED)-like domain but displayed different roles and
mechanisms in different biological activities. For example, while TIPE is primarily associated with tumor progression
and antitumor drug resistance, TIPE1 suppresses tumor progression in most instances. TIPE2 has multiple roles in
tumor progression regulation, and antitumor drug… More >
Open Access
ARTICLE
JIAZHUANG LI*, WEI ZHANG, SHOUBAO GAO, LI SUN, QINGYANG TAI, YING LIU
BIOCELL, DOI:10.32604/biocell.2023.029860
（This article belongs to this Special Issue: Non-Coding RNAs in the Regulation of Human Cancers)
Abstract Background: Trastuzumab resistance accounts for chemotherapy failure in gastric cancer patients in clinical
practice. The significance of long non-coding RNAs (lncRNAs) in the maintenance of drug resistance in gastric
cancer has been already underlined. Method: This study aimed to identify the specific role of lncRNA-ATB in gastric
cancer progression and trastuzumab resistance. The downstream miRs of lncRNA-ATB and target genes of miRs were
predicted by bioinformatics analysis and verified using dual luciferase reporter assay. Loss- and gain-function assays
were performed to explore the roles of lncRNA-ATB, miR-200c, and zinc-finger protein 217 (ZNF217) in the cell
functions and trastuzumab resistance of… More >
Login
Register
Submit a Paper
Propose a Special lssue
