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Neural Stem Cells in Health and Disease: Mechanisms and Applications

Submission Deadline: 31 March 2025 Submit to Special Issue

Guest Editors

Dr. Ibrahim Kassis, Unit of Neuroimmunology and Cell therapies and Multiple Sclerosis Center, Hadassah-Hebrew University Hospital, Israel.


Neural stem cells (NSCs) possess the capacity for self-renewal and differentiation into various neural cell types, playing crucial roles in the development, repair, and regeneration of the nervous system. This proposed special issue aims to gather cutting-edge research and latest advancements in the field of NSCs, exploring their mechanisms and applications in health and disease.


Research Focus including but not limited to:

1. Mechanisms of NSC Differentiation: We invite researchers to share their latest insights into the mechanisms underlying the differentiation of NSCs into specific neural cell types. This includes studies on transcription factors, signaling pathways, epigenetic regulation, and the influence of the extracellular environment on NSC fate determination.

2. Programmable Stem Cell Technologies: The advent of programmable stem cell technologies, such as CRISPR/Cas9-based gene editing, offers novel tools and possibilities for NSC research. We welcome studies on the application of gene editing technologies in NSC functional studies, disease modeling, and drug screening.

3. NSCs in Tissue Engineering: Special emphasis will be placed on the application of NSCs in tissue engineering, including their potential role in repairing and regenerating neural tissue. This includes the use of technologies like 3D bioprinting to fabricate neural tissues with specific structures and functions.

4. NSCs in Neurodegenerative Diseases: We encourage submissions related to the role of NSCs in understanding and treating neurodegenerative diseases such as Alzheimer's and Parkinson's. Efforts to utilize NSCs for disease modeling and exploration of novel therapeutic strategies are of particular interest.

5. Clinical Trials of NSC Therapies: Updates on clinical trials evaluating the safety and efficacy of NSC therapies for neurological disorders and injuries are welcome. These trials include the use of NSCs for treating conditions such as Parkinson's disease, spinal cord injuries, and cerebrovascular diseases.


We welcome submissions of original research and reviews that contribute to a deeper understanding of NSCs and promote their applications in medicine and clinical practice. Through this special issue, we aim to foster collaboration and exchange of ideas in the field of neural stem cell research.


neural stem cells, neurodegeneration, tissue repair, cell-replacement, CNS

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