Home / Journals / BIOCELL / Vol.47, No.9, 2023
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  • Open AccessOpen Access

    REVIEW

    A review on re-emerging bacteriophage therapy in the era of XDR

    POOJA BHADORIYA1, RICHA SHARMA1, REKHA MEHROTRA1, SIMRAN KAUR1, ISHA SRIVASTAVA1, MUKUL JAIN2, PRASHANT KAUSHIK3,*
    BIOCELL, Vol.47, No.9, pp. 1915-1930, 2023, DOI:10.32604/biocell.2023.029564
    Abstract In the present medicine world antibiotic resistance is one of the key threats to universal health coverage. Researchers continue to work hard to combat this global health concern. Phage therapy, an age-old practice during the early twentieth century, was outshined by the discovery of antibiotics. With the advent of widespread antibiotic resistance, phage therapy has again redeemed itself as a potential alternative owing to its adeptness to target bacteria precisely. Limited side effects, the ability to migrate to different body organs, a distinct mode of action, and proliferation at the infection site, make phages a… More >

    Graphic Abstract

    A review on re-emerging bacteriophage therapy in the era of XDR

  • Open AccessOpen Access

    ARTICLE

    Characterization of prognosis and immune infiltration by a novel glutamine metabolism-related model in cutaneous melanoma

    MENGQIN ZHU1,2,3,4,#, TIANYI XU5,#, HAN ZHANG3,4, XIN FAN3,4, YULAN WANG6, JIAJIA ZHANG3,4, FEI YU1,2,3,4,*
    BIOCELL, Vol.47, No.9, pp. 1931-1945, 2023, DOI:10.32604/biocell.2023.028968
    Abstract Glutamine metabolism (GM) plays an important role in tumor growth and proliferation. Skin cutaneous melanoma (SKCM) is a glutamine-dependent cancer. However, the molecular characteristics and action mechanism of GM on SKCM remain unclear. Therefore, we aimed to explore the effects of GM-related genes on survival, clinicopathological characteristics, and the tumor microenvironment in SKCM. In this study, 682 SKCM samples were obtained from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Consensus clustering was used to classify SKCM samples into distinct subtypes based on 41 GM-related genes. Differences in survival, immune infiltration, clinical… More >

    Graphic Abstract

    Characterization of prognosis and immune infiltration by a novel glutamine metabolism-related model in cutaneous melanoma

  • Open AccessOpen Access

    ARTICLE

    Initial steps on the analysis of the underlying pharmacological mechanisms of Wendan decoction on sudden deafness using network pharmacology and molecular docking

    SHIMING YE1,2,#, YUFENG ZHANG3,#, TING LIU4, CONG WANG3, ZHENG YAN5, WANDONG SHE2,*, HAIBING HUA4,*
    BIOCELL, Vol.47, No.9, pp. 1947-1964, 2023, DOI:10.32604/biocell.2023.029333
    (This article belongs to the Special Issue: Natural Products for Chronic Inflammatory Diseases: Pharmacology and Toxicology)
    Abstract Background: Despite its widespread therapeutic use and effectiveness, the underlying pharmacologic mechanisms of Wendan decoction (WDD) and how it works to treat sudden deafness (SD) remain unclear. In this study, the pharmacological mechanisms of WDD underlying SD were analyzed using network pharmacology and molecular docking. Methods: The Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) was employed to identify the active compounds and target genes of WDD, and genes associated with SD were screened on five databases. RGUI conducted Gene Ontology (GO) functional and the Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. A… More >

  • Open AccessOpen Access

    ARTICLE

    Novel defined N7-methylguanosine modification-related lncRNAs for predicting the prognosis of laryngeal squamous cell carcinoma

    ZHAOXU YAO*, HAIBIN MA, LIN LIU, QIAN ZHAO, LONGCHAO QIN, XUEYAN REN, CHUANJUN WU, KAILI SUN
    BIOCELL, Vol.47, No.9, pp. 1965-1975, 2023, DOI:10.32604/biocell.2023.030796
    Abstract Objective: Through integrated bioinformatics analysis, the goal of this work was to find new, characterised N7-methylguanosine modification-related long non-coding RNAs (m7G-lncRNAs) that might be used to predict the prognosis of laryngeal squamous cell carcinoma (LSCC). Methods: The clinical data and LSCC gene expression data for the current investigation were initially retrieved from the TCGA database & sanitised. Then, using co-expression analysis of m7G-associated mRNAs & lncRNAs & differential expression analysis (DEA) among LSCC & normal sample categories, we discovered lncRNAs that were connected to m7G. The prognosis prediction model was built for the training category… More >

  • Open AccessOpen Access

    ARTICLE

    Fang-Xia-Dihuang decoction inhibits breast cancer progression induced by psychological stress via down-regulation of PI3K/AKT and JAK2/STAT3 pathways: An in vivo and a network pharmacology assessment

    LINGYAN LV1,2,#, JING ZHAO1,2,#, XUAN WANG1,2, LIUYAN XU1,2, YINGYI FAN2, CHUNHUI WANG3, HONGQIAO FAN4,5,*, XIAOHUA PEI5,*
    BIOCELL, Vol.47, No.9, pp. 1977-1994, 2023, DOI:10.32604/biocell.2023.030742
    Abstract Background: The development and prognosis of breast cancer are intricately linked to psychological stress. In addition, depression is the most common psychological comorbidity among breast cancer survivors, and reportedly, Fang-Xia-Dihuang decoction (FXDH) can effectively manage depression in such patients. However, its pharmacological and molecular mechanisms remain obscure. Methods: Public databases were used for obtaining active components and related targets. Main active components were further verified by ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UPLC-HRMS). Protein–protein interaction and enrichment analyses were taken to predict potential hub targets and related pathways. Molecule docking was used to understand the interactions… More >

  • Open AccessOpen Access

    ARTICLE

    Exosomal miR-30a-5p targets NLRP3 to suppress podocyte pyroptosis in diabetic nephropathy

    WEI LU1,*, KAN GUO2, DIANMEI XI1, ZHAOXIA XIA1
    BIOCELL, Vol.47, No.9, pp. 1995-2008, 2023, DOI:10.32604/biocell.2023.024591
    (This article belongs to the Special Issue: Cell-Based Regenerative Therapies)
    Abstract Background: Mesenchymal stem cell (MSC)-derived exosomes are closely related to pyroptosis in diabetic nephropathy (DN). This study aimed to explore the protective effect of exosomal miR-30a-5p on podocyte pyroptosis in DN. Methods: Streptozotocin was used to establish the mouse model of DN. Human bone marrow MSC-derived exosomes were extracted and identified via transmission electron microscopy, nanoparticle tracking analysis, and western blotting. MiR-30a-5p mimics and non-control (NC) mimics were transfected into MSCs and podocytes, and exosomes were isolated from the MSCs. High glucose (HG)-induced podocyte model was established to determine the effect of exosomal miR-30a-5p on pyroptosis… More >

  • Open AccessOpen Access

    ARTICLE

    Silencing ribosomal protein L4 enhances the inhibitory effects of triptolide on non-small cell lung cancer cells by disrupting the mouse double minute 2 protein–P53 tumor suppressor pathway

    NAN TANG1,#, YAJING ZHAN1,#, JIAYAN MAO2,#, ANKANG YIN1, WEI WANG3,*, JUAN WANG3,*
    BIOCELL, Vol.47, No.9, pp. 2009-2026, 2023, DOI:10.32604/biocell.2023.029269
    (This article belongs to the Special Issue: Herbal Active Ingredients: Potential for the Prevention and Treatment of Cancer)
    Abstract Non-small cell lung cancer (NSCLC) is a malignant tumor with high incidence worldwide. Triptolide (TP), extracted from Tripterygium wilfordii Hook F, exhibits potent broad-spectrum antitumor activity. Although some mechanisms through which TP inhibits NSCLC are well understood, those that involve ribosomal proteins remain yet to be understood. In this study, the transcriptome and proteome were integrated and analyzed. Our data indicated ribosomal protein L4 (RPL4) to be a core hub protein in the protein-protein interaction network. RPL4 is overexpressed in NSCLC tissues and cells. Transfection with siRPL4 or TP treatment alone arrested the cell cycle in More >

    Graphic Abstract

    Silencing ribosomal protein L4 enhances the inhibitory effects of triptolide on non-small cell lung cancer cells by disrupting the mouse double minute 2 protein–P53 tumor suppressor pathway

  • Open AccessOpen Access

    ARTICLE

    The therapeutic mechanism of dexamethasone in lung injury induced by hydrogen sulfide

    CHUNYANG XU1,#, CAIYUN YANG1,#, JINSONG ZHANG2, XIAOHUA PAN3, JUN WANG4, LEI JIANG2, HONGWEI YE1,*, BO CHEN1,*
    BIOCELL, Vol.47, No.9, pp. 2027-2035, 2023, DOI:10.32604/biocell.2023.029277
    Abstract Background: The lung is one of the primary target organs of hydrogen sulfide (H2S), as exposure to H2S can cause acute lung injury (ALI) and pulmonary edema. Dexamethasone (Dex) exerts a protective effect on ALI caused by exposure to toxic gases and is commonly used in the clinic; however, the underlying mechanisms remain elusive, and the dose is unclear. Methods: In vivo experiments: divided C57BL6 mice into 6 groups at random, 12 in each group. The mice were exposed to H2S for 3 h and 5 or 50 mg/kg Dex pretreated before exposure, sacrificed 12 h later. The… More >

  • Open AccessOpen Access

    ARTICLE

    Heterogeneity beyond tumor heterogeneity—SULF2 involvement in Wnt/β-catenin signaling activation in a heterogeneous side population of liver cancer cells

    DONGYE YANG1,#,*, DONGDONG GUO2,3,#, YUNMEI PENG2, DONGMENG LIU1, YANQIU FU1, FEN SUN2, LISHI ZHOU1, JIAQI GUO1, LAIQING HUANG2,3,*
    BIOCELL, Vol.47, No.9, pp. 2037-2049, 2023, DOI:10.32604/biocell.2023.028863
    (This article belongs to the Special Issue: Application of Deep Learning in Cancer)
    Abstract Introduction: Sulfatase 2 (SULF2), an endogenous extracellular sulfatase, can remove 6-O-sulfate groups of glucosamine residues from heparan sulfate (HS) chains to modulate the Wnt/β-catenin signaling pathway, which plays an important role in both liver carcinogenesis and embryogenesis. Side population (SP) cells are widely identified as stem-like cancer cells and are closely related to carcinoma metastasis, recurrence, and poor patient prognosis. However, the roles of SULF2 in SP cells of hepatomas are unclear, and the underlying mechanism is undefined. Objectives: This study aimed to compare the heterogeneity between SP cells and non-side population (NSP) cells derived from… More >

    Graphic Abstract

    Heterogeneity beyond tumor heterogeneity—SULF2 involvement in Wnt/β-catenin signaling activation in a heterogeneous side population of liver cancer cells

  • Open AccessOpen Access

    ARTICLE

    Reversal of maternal obesity attenuates hypoxia and improves placental development in the preeclamptic-like BPH/5 mouse model

    DANIELLA M. ADAMS1, KALIE F. BECKERS1, JULIET P. FLANAGAN1, VIVIANE C. L. GOMES1,#, CHIN-CHI LIU1, JENNY L. SONES1,2,*
    BIOCELL, Vol.47, No.9, pp. 2051-2058, 2023, DOI:10.32604/biocell.2023.029644
    Abstract Background: Women with obesity have higher risk of adverse pregnancy outcomes, including preeclampsia (PE). Late-gestational hypertension, aberrant fetoplacental development, and fetal growth restriction (FGR), hallmarks of PE, are observed spontaneously in BPH/5 mice. Similar to obese preeclamptic women, BPH/5 mice have higher visceral white adipose tissue (WAT) and circulating leptin. We hypothesized that attenuation of maternal obesity and serum leptin in pregnant BPH/5 mice will improve fetoplacental development by decreasing hypoxia markers and leptin expression at the maternal-fetal interface. Methods: To test this hypothesis, BPH/5 mice were fed ad libitum (lib) and pair-fed (PF) to C57… More >

  • Open AccessOpen Access

    ARTICLE

    Identification of EML4 as a key hub gene for endometriosis and its molecular mechanism and potential drug prediction based on the GEO database

    XIANBAO FANG1,#, MINGYAN TANG1,#, ZIYANG YU1,#, JIAQI DING1, CHONG CUI2, HONG ZHANG1,*
    BIOCELL, Vol.47, No.9, pp. 2059-2068, 2023, DOI:10.32604/biocell.2023.030565
    (This article belongs to the Special Issue: Bioinformatics Study of Diseases)
    Abstract Objective: Key genes were screened to analyze molecular mechanisms and their drug targets of endometriosis by applying a bioinformatics approach. Methods: Gene expression profiles of endometriosis and healthy controls were obtained from the Gene Expression Omnibus database. Significant differentially expressed genes were screened using the limma package. Correlation pathways were screened by Spearman correlation analysis on the echinoderm microtubule-associated protein-like 4 (EML4) and enrichment in endometriosis pathways and estimated by the GSVA package. Immune characteristics were assessed by the “ESTIMATE” R package. Potential regulatory pathways were determined by enrichment analysis. The SWISS-MODE website was used in… More >

    Graphic Abstract

    Identification of EML4 as a key hub gene for endometriosis and its molecular mechanism and potential drug prediction based on the GEO database

  • Open AccessOpen Access

    ARTICLE

    Label-free quantitative proteomics analysis models in vivo and in vitro reveal key proteins and potential roles in sciatic nerve injury

    YANG GU1,#,*, MINGGUANG BI2,#, DEHUI CHEN3, NING NI4, JIANMING CHEN1,*
    BIOCELL, Vol.47, No.9, pp. 2069-2080, 2023, DOI:10.32604/biocell.2023.029989
    Abstract Background: The underlying mechanism of sciatic nerve injury (SNI) is a common motor functional disorder, necessitates further research. Methods: A rat model of SNI was established, with the injury group subjected to compressive injury of the right sciatic nerve exposed at the midpoint of the thigh and the sham surgery group undergoing the same surgical procedure. An oxygen-glucose deprivation model was employed to simulate in vitro SNI in PC12 cells. Following data acquisition and quality control, differentially expressed proteins (DEPs) in each model were identified through differential analysis, and enrichment analysis was used to explore the… More >

  • Open AccessOpen Access

    ARTICLE

    Designing a risk prognosis model based on natural killer cell-linked genes to accurately evaluate the prognosis of gastric cancer

    GAOZHONG LI, FUXIN LI, NING WEI, QING JIA*
    BIOCELL, Vol.47, No.9, pp. 2081-2099, 2023, DOI:10.32604/biocell.2023.029986
    Abstract Background: This study was aimed at identifying natural killer (NK) cell-related genes to design a risk prognosis model for the accurate evaluation of gastric cancer (GC) prognosis. Methods: We obtained NK cell-related genes from various databases, followed by Cox regression analysis and molecular typing to identify prognostic genes. Various immune algorithms and enrichment analyses were used to investigate the mutations, immune status, and pathway variations among different genotypes. The key prognostic genes were assessed using the least absolute shrinkage and selection operator (Lasso) regression analysis and univariate Cox regression analysis. Thereafter, the risk score (RS)… More >

    Graphic Abstract

    Designing a risk prognosis model based on natural killer cell-linked genes to accurately evaluate the prognosis of gastric cancer

  • Open AccessOpen Access

    ARTICLE

    Comparative transcriptome analysis provides insights into the molecular mechanism of the anti-nematode role of Arachis hypogaea (Fabales: Fabaceae) against Meloidogyne incognita (Tylenchida: Heteroderidae)

    XUEJIN YANG1,2,#, YUANYUAN ZHOU1,#, XINYI PENG1, XIAOHONG FU1, JIANQING MA1, JIANFENG LIU1,*, DANDAN CAO1,2,*
    BIOCELL, Vol.47, No.9, pp. 2101-2113, 2023, DOI:10.32604/biocell.2023.029581
    (This article belongs to the Special Issue: Plant Cell Physiology and Stress Biology)
    Abstract Background: Plant root-knot nematode (RKN) disease is a serious threat to agricultural production across the world. Meloidogyne incognita is the most prominent pathogen to the vegetables and cash crops cultivated. Arachis hypogaea can effectively inhibit M. incognita, but the underlying defense mechanism is still unclear. Methods: In our study, the chemotaxis and infestation of the second-stage juveniles (J2s) of M. incognita to A. hypogaea root tips were observed by the Pluronic F-127 system and stained with sodium hypochlorite acid fuchsin, respectively. The transcriptome data of A. hypogaea roots with non-infected or infected by J2s were analyzed. Results: The J2s could approach and infect… More >

  • Open AccessOpen Access

    ARTICLE

    MED4 gene positively affects preadipocyte differentiation in Chinese red steppe cattle

    MINGHONG WEI1,#, CHENG XIAO1,2,#, JIAN WU1,3, LIHONG QIN1,3, HONGLIANG LIU1,3, YANG CAO1,*, YUMIN ZHAO1,3,*
    BIOCELL, Vol.47, No.9, pp. 2115-2123, 2023, DOI:10.32604/biocell.2023.030364
    (This article belongs to the Special Issue: Cellular Signal Transduction in Biological Activities)
    Abstract Background: The regulatory genes related to lipid metabolism affect the intramuscular fat (IMF) content and improve meat quality traits. Mediator Complex Subunit 4 (MED4), a vitamin D receptor protein, affects vitamin D, livestock growth, carcass traits, and triglyceride deposition. However, the physiological function of the MED4 gene on bovine adipocyte differentiation remains unknown. Methods: This study explored the function of the MED4 gene in preadipocyte differentiation in Chinese Red Steppe cattle. The overexpression plasmid and the interference sequences of the MED4 gene were constructed to detect the effects of the MED4 gene on adipogenesis and biomakers using More >

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