Home / Journals / BIOCELL / Vol.35, No.3, 2011
Table of Content
  • Open Access

    ARTICLE

    Protective effect of aqueous suspension of dried latex of Calotropis procera against oxidative stress and renal damage in diabetic rats

    VIJAY L. KUMAR* AND BISWA M. PADHY
    BIOCELL, Vol.35, No.3, pp. 63-70, 2011, DOI:10.32604/biocell.2011.35.063
    Abstract Calotropis species have been used in the traditional medicinal system for the treatment of diseases of the liver and abdomen. In view of the antioxidant and anti-hyperglycemic properties of an aqueous suspension obtained from the dried latex of Calotropis procera, the present study was carried out to evaluate its efficacy in affording protection against alloxan induced changes in rat kidney. A single intraperitoneal injection of alloxan (150 mg/kg) in rats produced hyperglycemia within 3 days and altered kidney functions over a period of 90 days. Daily oral administration of the aqueous suspension (100 and 400 mg/kg) in diabetic rats produced… More >

  • Open Access

    ARTICLE

    Apigenin inhibits cell migration through MAPK pathways in human bladder smooth muscle cells

    QINGXIN LIU , XIANGGUI CHEN, GUOLIN YANG1 , XUEWEN MIN3 , AND MAOXIAN DENG1,*
    BIOCELL, Vol.35, No.3, pp. 71-80, 2011, DOI:10.32604/biocell.2011.35.071
    Abstract Apigenin, a nonmutagenic flavonoid, has been shown to possess free radical scavenging activities, anticarcinogenic properties, antioxidant and anti-inflammatory effects. Recently, apigenin was reported to cause gastric relaxation in murine. To assess possible effects of apigenin on migration of bladder smooth muscle (SM) cell, we isolated SM cells from peri-cancer tissue of human bladder and established a cell model that was capable to overexpress transiently MEKK1 (MEK kinase 1). Results showed that overexpression of active human MEKK1 by adenoviruses infection induced migration of human bladder smooth muscle (hBSM) cells and phosphorylation of MAPKs, ERK, JNK and p38, which are the downstream… More >

  • Open Access

    ARTICLE

    The actin filament network associated to Sertoli cell ectoplasmic specializations

    JUAN CARLOS CAVICCHIA1*, MABEL FÓSCOLO1 , JORGE IBAÑEZ1, CHRISTOPHER LILLIG2, FRANCISCO CAPANI3
    BIOCELL, Vol.35, No.3, pp. 81-90, 2011, DOI:10.32604/biocell.2011.35.081
    Abstract Junctional devices in Sertoli cells conform the blood-testis barrier and play a key role in maturation and differentiation of germ cells. The spacial distribution of ectoplasmic specializations of Sertoli cells was studied by β-actin immunolabelling, using laser confocal and transmission electron microscopy. For confocal microscopy, β-actin immunolabelling of ectoplasmic specializations was studied over the background of either prosaposin or glutaredoxin immunolabelling of the Sertoli cytoplasm. Labelling was found near the basal lamina, surrounding early spermatocytes (presumably in leptotene-zygotene) or at one of two levels in the seminiferous epithelium: (1) around deep infoldings of the Sertoli cell cytoplasm, in tubular stages… More >

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