Apigenin inhibits cell migration through MAPK pathways in human bladder smooth muscle cells
QINGXIN LIU1§ , XIANGGUI CHEN2§, GUOLIN YANG1 , XUEWEN MIN3 , AND MAOXIAN DENG1,*
BIOCELL, Vol.35, No.3, pp. 71-80, 2011, DOI:10.32604/biocell.2011.35.071
Abstract Apigenin, a nonmutagenic flavonoid, has been shown to possess free radical scavenging activities, anticarcinogenic properties, antioxidant and anti-inflammatory effects. Recently, apigenin was reported
to cause gastric relaxation in murine. To assess possible effects of apigenin on migration of bladder smooth
muscle (SM) cell, we isolated SM cells from peri-cancer tissue of human bladder and established a cell model
that was capable to overexpress transiently MEKK1 (MEK kinase 1). Results showed that overexpression of
active human MEKK1 by adenoviruses infection induced migration of human bladder smooth muscle (hBSM)
cells and phosphorylation of MAPKs, ERK, JNK and p38, which are the downstream… More >
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