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Gut Microbiota in Human Health: Exploring the Complex Interplay

Submission Deadline: 31 July 2024 Submit to Special Issue

Guest Editors

Dr. N. S. Chauhan, Department of Biochemistry, Maharshi Dayanand University, India.
Dr. Stanislav Kotlyarov, Department of Nursing, Ryazan State Medical University, Russia.
Dr. Hongsong Yu, Department of Immunology, Zunyi Medical University, China.
Dr. Zhen Li, Department of Gastroenterology, Qilu Hospital of Shandong University, China.


The human gut microbiota has emerged as a pivotal player in maintaining health. This special issue aimed to bring together cutting-edge research, reviews, and perspectives on the multifaceted relationship between gut microbiota and human health. We invite contributions exploring the latest advancements in understanding the role of gut microbiota in health, the mechanisms involved, and potential therapeutic implications.


Topics of Interest may include but not be limited to:

1. Gut Microbiota and Immune System Crosstalk: Investigating how the gut microbiota influences the development and function of the immune system, and how the immune system, in turn, shapes the gut microbiome. This may encompass studies on immune modulation, inflammation, and the role of microbiota in immune-mediated diseases.

2. Gut Microbiota and Metabolic Health: Exploring the impact of gut microbiota on host metabolism, including its role in obesity, diabetes, cardiovascular diseases, etc. Studies on microbial metabolites and their influence on metabolic processes are welcome.

3. Gut Microbiota and Neurological Health: Investigating the gut-brain axis and how the microbiota influences neurological function and mental health. Articles on microbiota's role in neurodevelopmental and neurodegenerative diseases are encouraged.

4. Gut Microbiota and Cancer: Highlighting the relationship between the gut microbiota and cancer development, progression, and therapy response. Contributions may focus on colorectal cancer or explore the microbiome's role in other cancer types.

5. Therapeutic Interventions: Discuss microbiome-targeted therapeutic strategies, such as probiotics, prebiotics, postbiotics, antibiotics, fecal microbiota transplantation (FMT), and personalized microbiome therapy. Articles on clinical applications are encouraged.

6. Dysbiosis and Disease: Investigating how microbiota dysbiosis contributes to the pathogenesis of various diseases, including inflammatory bowel diseases, autoimmune disorders, and infectious diseases.

7. Microbiome and Precision Medicine: Addressing the potential for microbiome-based precision medicine, including diagnostic and therapeutic applications, and the challenges involved.


This special issue aims to provide a comprehensive overview of the current state of research on gut microbiota and its impact on human health. By fostering collaboration and presenting the latest findings, it will contribute to our understanding of the complex interplay between gut microbiota and various aspects of human health, paving the way for potential advancements in diagnostics and therapeutics. Manuscripts can be original research articles, review papers, perspectives, or short communications. All contributions will be subject to peer review to ensure high quality and scientific rigor.


human microbiota, gut microbiome, host-microbe interactions, microbiota and human health, microbiota dysbiosis, microbiome therapeutics

Published Papers

  • Open Access


    Does young feces make the elderly live better? Application of fecal microbiota transplantation in healthy aging

    BIOCELL, DOI:10.32604/biocell.2024.050324
    (This article belongs to the Special Issue: Gut Microbiota in Human Health: Exploring the Complex Interplay)
    Abstract As we are facing an aging society, anti-aging strategies have been pursued to reduce the negative impacts of aging and increase the health span of human beings. Gut microbiota has become a key factor in the anti-aging process. Modulation of gut microbiota by fecal microbiota transplantation (FMT) to prevent frailty and unhealthy aging has been a hot topic of research. This narrative review summarizes the benefits of FMT for health span and lifespan, brains, eyes, productive systems, bones, and others. The mechanisms of FMT in improving healthy aging are discussed. The increased beneficial bacteria and More >

  • Open Access


    How aging affects bone health via the intestinal micro-environment

    BIOCELL, Vol.48, No.3, pp. 353-362, 2024, DOI:10.32604/biocell.2024.048311
    (This article belongs to the Special Issue: Gut Microbiota in Human Health: Exploring the Complex Interplay)
    Abstract Increasing life expectancy and an aging population lead to age-related bone diseases like osteoporosis and low bone mass more prevalent. These conditions represent a common, costly and chronic burden, not only for elderly but also to society at large. Consequently, elucidating the pathophysiology and developing effective therapies for these diseases is of paramount importance. Recent advances in research have identified the gut as a novel and promising target for addressing bone disorders, giving rise to the concept of the “gut-bone axis”. An in-depth review of the latest insights into the effects of age-related physiological changes More >

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