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How aging affects bone health via the intestinal micro-environment

HUAN HU1,2,*, YUE HUANG1, FANGZHOU LIU1, QIAN WANG1,2, YANZI YAO3,*

1 School of Stomatology, Zunyi Medical University, Zunyi, China
2 Microbial Resources and Drug Development Key Laboratory of Guizhou Tertiary Institution, Zunyi Medical University, Zunyi, China
3 Department of Stomatology, Luoyang Maternal and Child Health Hospital, Luoyang, China

* Corresponding Authors: HUAN HU. Email: email; YANZI YAO. Email: email

(This article belongs to the Special Issue: Gut Microbiota in Human Health: Exploring the Complex Interplay)

BIOCELL 2024, 48(3), 353-362. https://doi.org/10.32604/biocell.2024.048311

Abstract

Increasing life expectancy and an aging population lead to age-related bone diseases like osteoporosis and low bone mass more prevalent. These conditions represent a common, costly and chronic burden, not only for elderly but also to society at large. Consequently, elucidating the pathophysiology and developing effective therapies for these diseases is of paramount importance. Recent advances in research have identified the gut as a novel and promising target for addressing bone disorders, giving rise to the concept of the “gut-bone axis”. An in-depth review of the latest insights into the effects of age-related physiological changes in the gastrointestinal tract on bone health is presented in this article. It examines how the “gut-bone” axis interacts with bone aging across various domains, including metabolism, nutrition, intestinal permeability, immunity, and oxidative stress.

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APA Style
HU, H., HUANG, Y., LIU, F., WANG, Q., YAO, Y. (2024). How aging affects bone health via the intestinal micro-environment. BIOCELL, 48(3), 353-362. https://doi.org/10.32604/biocell.2024.048311
Vancouver Style
HU H, HUANG Y, LIU F, WANG Q, YAO Y. How aging affects bone health via the intestinal micro-environment. BIOCELL . 2024;48(3):353-362 https://doi.org/10.32604/biocell.2024.048311
IEEE Style
H. HU, Y. HUANG, F. LIU, Q. WANG, and Y. YAO "How aging affects bone health via the intestinal micro-environment," BIOCELL , vol. 48, no. 3, pp. 353-362. 2024. https://doi.org/10.32604/biocell.2024.048311



cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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