Special lssues
Table of Content

Cell Death and Inflammation in Signaling and Diseases

Submission Deadline: 31 December 2024 Submit to Special Issue

Guest Editors

Prof. Jiann-Ruey Hong, Laboratory of Molecular Virology and Biotechnology, Institute of Biotechnology, National Cheng Kung University, Tainan 701, Taiwan.


Cell death and inflammation are intricately linked processes that play pivotal roles in signaling cascades and the pathogenesis of various diseases. Understanding the molecular mechanisms underlying the interplay between cell death and inflammation is crucial for unraveling disease etiology and developing targeted therapeutic interventions. This special issue aims to bring together leading researchers to explore the complex relationships between cell death and inflammation, shedding light on signaling pathways and their implications for a spectrum of diseases.


Topics to be covered:

1. Mechanisms of Cell Death Signaling:

In-depth analysis of the molecular pathways regulating apoptosis, necroptosis, pyroptosis, and other forms of cell death.

The role of key signaling molecules and their crosstalk in orchestrating cell death responses.

Advances in understanding the regulatory mechanisms that dictate cell fate decisions.

2. Inflammation Signaling Pathways:

Exploration of inflammatory signaling cascades, including the role of cytokines, chemokines, and inflammasomes.

The impact of immune cell activation and the role of pattern recognition receptors in inflammation.

Insights into how dysregulated inflammatory signaling contributes to various pathological conditions.

3. Cell Death and Inflammation in Diseases:

Comprehensive reviews on the involvement of cell death and inflammation in specific diseases, such as cancer, neurodegenerative disorders, autoimmune diseases, and infectious diseases.

Identification of key molecular targets and pathways that could serve as potential therapeutic interventions.

Case studies highlighting the clinical relevance of understanding cell death and inflammation in disease progression.

4. Emerging Technologies and Experimental Models:

Cutting-edge technologies for studying cell death and inflammation, including single-cell approaches, CRISPR-based screens, and advanced imaging techniques.

Development and application of novel experimental models to better mimic disease conditions and unravel underlying mechanisms.

Integration of omics data to provide a systems-level understanding of cell death and inflammation dynamics.

5. Therapeutic Strategies and Future Directions:

Overview of current therapeutic approaches targeting cell death and inflammation in various diseases.

Identification of potential drug candidates and innovative strategies for modulating cell death and inflammation.

Future perspectives and challenges in translating basic research findings into clinical applications.


This special issue aims to serve as a comprehensive resource for researchers and clinicians interested in the intricate interplay between cell death and inflammation in signaling and disease. By bringing together diverse perspectives and cutting-edge research, this collection will contribute to advancing our understanding of disease mechanisms and foster the development of novel therapeutic strategies.


Cell Death, Inflammation Signaling, Signaling Pathway, Diseases, Cutting-Edge Research, CRISPR-Based Screens, Therapeutic Strategies

Published Papers

  • Open Access


    UBE2T mediates the stemness properties of breast cancer cells through the mTOR signaling pathway

    BIOCELL, DOI:10.32604/biocell.2024.049349
    (This article belongs to the Special Issue: Cell Death and Inflammation in Signaling and Diseases)
    Abstract Objectives: This study aimed to reveal the role and possible mechanism of the ubiquitin-conjugating enzyme 2T (UBE2T) in the biological activities of breast cancer stem cells (BCSCs). Methods: The specific protein and gene expression were quantified by Western blotting and quantitative real-time polymerase chain reaction, the proportion of BCSCs was examined by flow cytometry, and the self-renewal and proliferation of BCSCs were verified by serial sphere formation and soft agar. Results: Increasing expression of UBE2T was drastically found in breast cancer than that in adjacent tissues. Furthermore, UBE2T overexpression significantly increased the proportion of BCSCs in More >

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