Guest Editors
Prof. Jiann-Ruey Hong, Laboratory of Molecular Virology and Biotechnology, Institute of Biotechnology, National Cheng Kung University, Tainan 701, Taiwan.
Summary
Cell death and inflammation are intricately linked processes that play pivotal roles in signaling cascades and the pathogenesis of various diseases. Understanding the molecular mechanisms underlying the interplay between cell death and inflammation is crucial for unraveling disease etiology and developing targeted therapeutic interventions. This special issue aims to bring together leading researchers to explore the complex relationships between cell death and inflammation, shedding light on signaling pathways and their implications for a spectrum of diseases.
Topics to be covered:
1. Mechanisms of Cell Death Signaling:
In-depth analysis of the molecular pathways regulating apoptosis, necroptosis, pyroptosis, and other forms of cell death.
The role of key signaling molecules and their crosstalk in orchestrating cell death responses.
Advances in understanding the regulatory mechanisms that dictate cell fate decisions.
2. Inflammation Signaling Pathways:
Exploration of inflammatory signaling cascades, including the role of cytokines, chemokines, and inflammasomes.
The impact of immune cell activation and the role of pattern recognition receptors in inflammation.
Insights into how dysregulated inflammatory signaling contributes to various pathological conditions.
3. Cell Death and Inflammation in Diseases:
Comprehensive reviews on the involvement of cell death and inflammation in specific diseases, such as cancer, neurodegenerative disorders, autoimmune diseases, and infectious diseases.
Identification of key molecular targets and pathways that could serve as potential therapeutic interventions.
Case studies highlighting the clinical relevance of understanding cell death and inflammation in disease progression.
4. Emerging Technologies and Experimental Models:
Cutting-edge technologies for studying cell death and inflammation, including single-cell approaches, CRISPR-based screens, and advanced imaging techniques.
Development and application of novel experimental models to better mimic disease conditions and unravel underlying mechanisms.
Integration of omics data to provide a systems-level understanding of cell death and inflammation dynamics.
5. Therapeutic Strategies and Future Directions:
Overview of current therapeutic approaches targeting cell death and inflammation in various diseases.
Identification of potential drug candidates and innovative strategies for modulating cell death and inflammation.
Future perspectives and challenges in translating basic research findings into clinical applications.
This special issue aims to serve as a comprehensive resource for researchers and clinicians interested in the intricate interplay between cell death and inflammation in signaling and disease. By bringing together diverse perspectives and cutting-edge research, this collection will contribute to advancing our understanding of disease mechanisms and foster the development of novel therapeutic strategies.
Keywords
Cell Death, Inflammation Signaling, Signaling Pathway, Diseases, Cutting-Edge Research, CRISPR-Based Screens, Therapeutic Strategies
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