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New Perspectives on Inflammatory Cancer Transformation

Submission Deadline: 31 January 2025 Submit to Special Issue

Guest Editors


Prof. Dr. Zhongchuan Wang,
Department of Anal and Intestinal Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, China


Prof. Dr. Dong Tang,
Department of General Surgery, Institute of General Surgery, Northern Jiangsu Province Hospital, Clinical Medical College, Yangzhou University, China

Summary

Cancers are one of the major challenges in today's global public health system. It is difficult to attribute its origin to a particular hypothesis. Among them, the inflammation-cancer transition hypothesis has been a hot research topic among clinical and basic scientists, with the intention of revealing the intricate link between chronic inflammatory processes and the progression of malignant tumours. The inflammatory microenvironment provides a powerful driving force for the shaping of the tumor microenvironment. Inflammation-cancer transition not only encompasses complex cellular interactions, molecular mechanisms, and immune regulation, but is also accompanied by dynamic changes in disease phenotype and function. Therefore, there is an urgent need to identify the complex mechanisms involved in the transition from inflammatory conditions to cancer, and to elucidate the key factors influencing this transition, as well as the implications for disease progression and therapeutic strategies. The aim of this topic is to identify molecular markers related to inflammatory-cancer transition from different perspectives, to explore the molecular mechanisms of inflammation-cancer transition, and the application of related technologies or products in disease diagnosis or treatment, so as to provide new strategies for the treatment of inflammatory or cancerous conditions. We welcome, but are not limited to, manuscripts in the fields of inflammation, cancer, high-throughput sequencing, microbiota-related technologies, drug discovery, and other related fields.  


Keywords

inflammation, cancer, high-throughput sequencing, microbiota-related technologies, drug discovery, inflammatory factor, transcription factor, multi-omics analysis, bioinformatics

Published Papers


  • Open Access

    ARTICLE

    miR-557 suppresses hepatocellular carcinoma cell proliferation and migration via downregulating CBX4

    XULONG SUN, WENTAO DING, CHAO JIANG, ZHIAN FANG
    BIOCELL, DOI:10.32604/biocell.2024.050519
    (This article belongs to the Special Issue: New Perspectives on Inflammatory Cancer Transformation)
    Abstract Introduction: Hepatocellular carcinoma (HCC), a prevalent malignancy, poses significant challenges with high tumor heterogeneity and poor prognosis. MicroRNAs (miRNAs) play a pivotal role in hepatocarcinogenesis. Although abnormalities in microRNA-557 (miR-557) expression have been implicated in various cancer types, its role in HCC remains unclear. Therefore, there is a need to explore the function of microRNA-557 in HCC. Methods: Candidate miRNAs were identified through screening in GSE108724 and GSE20077. Real-time PCR was employed to analyze the expression level of miR-557 in hepatoma cell lines and tissues. Cell viability and migration assays were applied to assess the… More >

    Graphic Abstract

    miR-557 suppresses hepatocellular carcinoma cell proliferation and migration via downregulating CBX4

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