Special lssues
Table of Content

Exosomes in Cell Communication and Disease: From Biomarkers to Therapeutic Targets

Submission Deadline: 31 August 2024 Submit to Special Issue

Guest Editors

Natalia A. Osna, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, USA. nosna@unmc.edu

Zhijia Xia, Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians University, Germany. Zhijia.Xia@med.uni-muenchen.de


This special issue seeks to provide a comprehensive understanding of exosomes, their biogenesis, release pathways, content, and functions in various diseases, including cancer, cardiovascular diseases, obesity, sleep disorders, and neurodegenerative deficits. We have outlined the following key areas of focus:


Exosome Biogenesis, Release, and Content:

  • lInvestigate the mechanisms of exosome biogenesis and release pathways.

  • lExplore the diverse content of exosomes, including lipids, proteins, miRNAs, mRNAs, and other genetic materials.


Exosomes as Biomarkers:

  • Explore the potential of exosomes as diagnostic biomarkers in different diseases.

  • Discuss the specificity of exosomal cargos as indicators of disease onset and progression.


Immunosuppressive Exosomes in Disease Microenvironments:

  • Investigate the presence and heterogeneity of immunosuppressive exosomes in tumor and chronic inflammatory microenvironments.

  • Identify specific exosomal constituents responsible for immunosuppression.


Therapeutic Strategies Targeting Exosomes:

  • Assess the viability of targeting exosomes as a therapeutic intervention in diseases with immunosuppressive microenvironments.

  • Explore innovative strategies to modulate exosome release, uptake, or cargo content for therapeutic benefits.


Exosomes; Cancer; Biogenesis; Biomarkers; Immunology

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