Open Access

VIEWPOINT

New paradigms in regenerative engineering: Emerging role of extracellular vesicles paired with instructive biomaterials

W. BENTON SWANSON, YUJI MISHINA^*
Department of Biologic and Materials Science & Prosthodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, 48109, USA
* Address correspondence to: Yuji Mishina,
(This article belongs to this Special Issue: Mesenchymal Stem Cells, Secretome and Biomaterials: Regenerative Medicine Application)

BIOCELL 2022, 46(6), 1445-1451. https://doi.org/10.32604/biocell.2022.018781

Received 16 August 2021; Accepted 24 November 2021; Issue published 07 February 2022

Abstract

Mesenchymal stem cells (MSCs) have long been regarded as critical components of regenerative medicine strategies, given their multipotency and persistence in a variety of tissues. Recently, the specific role of MSCs in mediating regenerative outcomes has been attributed (in part) to secreted factors from transplanted cells, namely extracellular vesicles. This viewpoint manuscript highlights the promise of cell-derived extracellular vesicles as agents of regeneration, enhanced by synergy with appropriate biomaterials platforms. Extracellular vesicles are a potentially interesting regenerative tool to enhance the synergy between MSCs and biomaterials. As a result, we believe these technologies will improve patient outcomes through efficient therapeutic strategies resulting in predictable patient outcomes.

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Keywords

Biomaterials; Extracellular vesicles; Mesenchymal stem cells; Regenerative medicine; Tissue engineering

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