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Stem cells in intervertebral disc regeneration–more talk than action?

PETRA KRAUS1,*, ANKITA SAMANTA1, SINA LUFKIN2, THOMAS LUFKIN1

1 Department of Biology, Clarkson University, Potsdam, NY 13699, USA
2 The Clarkson School, Clarkson University, Potsdam, NY 13699, USA

* Corresponding Author: PETRA KRAUS. Email: email

(This article belongs to this Special Issue: Mesenchymal Stem Cells, Secretome and Biomaterials: Regenerative Medicine Application)

BIOCELL 2022, 46(4), 893-898. https://doi.org/10.32604/biocell.2022.018432

Abstract

Pain and lifestyle changes are common consequences of intervertebral disc degeneration (IVDD) and affect a large part of the aging population. The stemness of cells is exploited in the field of regenerative medicine as key to treat degenerative diseases. Transplanted cells however often face delivery and survival challenges, especially in tissues with a naturally harsh microniche environment such as the intervertebral disc. Recent interest in the secretome of stem cells, especially cargo protected from microniche-related decay as frequently present in degenerating tissues, provides new means of rejuvenating ailing cells and tissues. Exosomes, a type of extracellular vesicles with purposeful cargo gained particular interest in conveying stem cell related attributes of rejuvenation, which will be discussed here in the context of IVDD.

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Cite This Article

KRAUS, P., SAMANTA, A., LUFKIN, S., LUFKIN, T. (2022). Stem cells in intervertebral disc regeneration–more talk than action?. BIOCELL, 46(4), 893–898.



cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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