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Three-dimensional cell-based strategies for liver regeneration

DAN GUO1, XI XIA2,*, JIAN YANG1,*

1 Liver Transplant Center, Transplant Center, West China Hospital, Sichuan University, Chengdu, 610041, China
2 Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu, 610212, China

* Corresponding Authors: XI XIA. Email: email; JIAN YANG. Email: email

(This article belongs to the Special Issue: Perspectives on Stem Cells and Regenerative Medicine)

BIOCELL 2024, 48(7), 1023-1036. https://doi.org/10.32604/biocell.2024.051095

Abstract

Liver regeneration and the development of effective therapies for liver failure remain formidable challenges in modern medicine. In recent years, the utilization of 3D cell-based strategies has emerged as a promising approach for addressing these urgent clinical requirements. This review provides a thorough analysis of the application of 3D cell-based approaches to liver regeneration and their potential impact on patients with end-stage liver failure. Here, we discuss various 3D culture models that incorporate hepatocytes and stem cells to restore liver function and ameliorate the consequences of liver failure. Furthermore, we explored the challenges in transitioning these innovative strategies from preclinical studies to clinical applications. The collective insights presented herein highlight the significance of 3D cell-based strategies as a transformative paradigm for liver regeneration and improved patient care.

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APA Style
GUO, D., XIA, X., YANG, J. (2024). Three-dimensional cell-based strategies for liver regeneration. BIOCELL, 48(7), 1023-1036. https://doi.org/10.32604/biocell.2024.051095
Vancouver Style
GUO D, XIA X, YANG J. Three-dimensional cell-based strategies for liver regeneration. BIOCELL . 2024;48(7):1023-1036 https://doi.org/10.32604/biocell.2024.051095
IEEE Style
D. GUO, X. XIA, and J. YANG "Three-dimensional cell-based strategies for liver regeneration," BIOCELL , vol. 48, no. 7, pp. 1023-1036. 2024. https://doi.org/10.32604/biocell.2024.051095



cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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