Open Access

REVIEW

Review : Reticulocyte maturation: mitoptosis and exosome release

CHARLES GÉMINARD, AUDE DE GASSART, MICHEL VIDAL

UMR CNRS 5539, Université Montpellier II, cc107, 34095 Montpellier, France

Corresponding Author: Michel Vidal, Tel.: (+33-467) 144 777; Fax: (+33467) 144 286; E-mail:

BIOCELL 2002, 26(2), 205-215. https://doi.org/10.32604/biocell.2002.26.205

Abstract

During the differentiation of erythroid cells, a vast program of maturation takes place, leading to decay or elimination of organelles, including the nucleus, mitochondria, ribosomes, lysosomes, endoplasmic reticulum and Golgi apparatus. During the last step of red cell maturation, remaining organelles, primarily mitochondria and ribosomes but also vestiges of others are finally cleared from the cell. This cleaning session also affects specific proteins that are partially or entirely removed from the cell surface. The interplay of the various events and their causal relationships are approached here.

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