Special Issue "Stem Cells, Protein Therapeutics, and Regenerative Medicine"

Submission Deadline: 15 October 2020 (closed)
Guest Editors
Dr. Qinan Yin, NIH Clinical Center, National Institutes of Health
Professor. Dr. Jianjie Ma, The Ohio State University (OSU)
Professor. Dr. Xuehong Xu, Shanxi Normal University College of Life Sciences
Dr. Mouna Orchari, Columbia university


Regenerative medicine brings promise to redefine medical treatment of acute organ injuries and degenerative human diseases. Although many breakthroughs have been reported and hailed in scientific journals over the years, the number of regenerative medicine treatments in medical use today is still limited and the efficacy is variable and transient because more comprehensive investigation is required for understanding the biology of tissue-repair and regeneration and the cellular mechanism of stem cell niche. This special issue in the journal BIOCELL is intended to new molecules and new approaches for treatment of depression in preclinical and clinical studies.

The focus of this special issue is to capture the current advances in cell membrane repair and stem cell regenerative biology. The fusion of these two topics reflects the hope and potential that advance can advance regenerative medicine for translational application to treat human diseases. We will identify leading scientists in these fields and bring priority articles fitting the Journal BIOCELL. 

Biology of cell membrane repair; Regenerative medicine; Cell and tissue engineering; Embryonic development; Stem cell

Published Papers
  • The role of HBD-2, HBD-3, and calprotectin in the relationship between chronic periodontitis and atherosclerosis
  • Abstract This study was carried out to compare individuals diagnosed with atherosclerosis and periodontal periodontitis based on the degree of change in the human beta-defensins (HBD) HBD-2, HBD-3, and calprotectin. Atherosclerosis is the most frequently observed cardiovascular disease. Dental and periodontal infections are known to provide a considerable basis for atheroma plaque formation. The study group consists of a total number of 40 subjects, with 20 patients diagnosed with atherosclerosis and chronic periodontitis and 20 systemically healthy patients diagnosed with chronic periodontitis. Clinical periodontal and blood parameters and HBD-2, HBD-3, and calprotectin biomarkers in the gingival crevicular fluid were measured. In… More
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  • Enhanced osteogenic differentiation of human periodontal ligament stem cells by suberoylanilide hydroxamic acid
  • Abstract Periodontitis is a type of chronic inflammation in the gingival tissue caused by infectious bacteria colonizing the surface of the teeth, leading to the destruction of tooth-supporting tissues and loss of alveolar bone. Suberoylanilide hydroxamic acid (SAHA), a class of histone deacetylase (HDAC) inhibitor, has the potential to stimulate osteoblast differentiation by acetylating histone proteins, and thus suppressing the expression of adipogenic and chondrogenic genes. However, the effect of SAHA on the differentiation of human periodontal ligament stem cells (hPDLSCs) is yet to be elucidated. Herein, we investigated the effects of SAHA on in vitro proliferation and differentiation of hPDLSCs… More
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