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Stem Cells, Protein Therapeutics, and Regenerative Medicine

Submission Deadline: 15 October 2020 (closed)

Guest Editors

Dr. Qinan Yin, NIH Clinical Center, National Institutes of Health
Professor. Dr. Jianjie Ma, The Ohio State University (OSU)
Professor. Dr. Xuehong Xu, Shanxi Normal University College of Life Sciences
Dr. Mouna Orchari, Columbia university

Summary

Regenerative medicine brings promise to redefine medical treatment of acute organ injuries and degenerative human diseases. Although many breakthroughs have been reported and hailed in scientific journals over the years, the number of regenerative medicine treatments in medical use today is still limited and the efficacy is variable and transient because more comprehensive investigation is required for understanding the biology of tissue-repair and regeneration and the cellular mechanism of stem cell niche. This special issue in the journal BIOCELL is intended to new molecules and new approaches for treatment of depression in preclinical and clinical studies.

The focus of this special issue is to capture the current advances in cell membrane repair and stem cell regenerative biology. The fusion of these two topics reflects the hope and potential that advance can advance regenerative medicine for translational application to treat human diseases. We will identify leading scientists in these fields and bring priority articles fitting the Journal BIOCELL.

Keywords

Biology of cell membrane repair; Regenerative medicine; Cell and tissue engineering; Embryonic development; Stem cell

Published Papers

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Open Access

REVIEW

Ubiquitin-like posttranslational modifications in NAFLD progression and treatment
FUJI YANG, YAN HUANG, YOUWEN TAN, YONGMIN YAN
BIOCELL, Vol.46, No.2, pp. 389-400, 2022, DOI:10.32604/biocell.2021.015899
（This article belongs to this Special Issue: Stem Cells, Protein Therapeutics, and Regenerative Medicine)
Abstract Nonalcoholic fatty liver disease (NAFLD) is a long-lasting condition that affects the liver, destroying its function. Liver injury can cause steatosis and inflammation, and further activation of hepatic stellate cells (HSCs) often leads to the development of nonalcoholic liver fibrosis. The patient with NAFLD is at risk of developing advanced liver disease and complications, such as liver failure, hepatocellular carcinoma (HCC), and portal hypertension. Although our understanding of the cellular and molecular mechanisms of NAFLD has greatly improved in recent years, treatment remains limited. Analysis and characterization of protein posttranslational modifications (PTMs) could improve our understanding of NAFLD pathology and… More >

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Epigenetic regulation−The guardian of cellular homeostasis and lineage commitment
KAVITHA GOVARTHANAN, PIYUSH KUMAR GUPTA, BINITA ZIPPORAHE, REKHA GAHTORI, SOUMYA PANDIT, RAM PRASAD
BIOCELL, Vol.45, No.3, pp. 501-515, 2021, DOI:10.32604/biocell.2021.014441
（This article belongs to this Special Issue: Stem Cells, Protein Therapeutics, and Regenerative Medicine)
Abstract Stem cells constitute the source of cells that replenishes the worn out or damaged cells in our tissue and enable the tissue to carry out the destined function. Tissue-specific stem cells are compartmentalized in a niche, which keeps the stem cells under quiescent condition. Thus, understanding the molecular events driving the successful differentiation of stem cells into several lineages is essential for its better manipulation of human applications. Given the developmental aspects of the cell, the cellular function is greatly dependent on the epigenomics signature that in turn governs the expression profile of the cell. The stable inheritance of the… More >

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REVIEW

Mesenchymal stem cell-derived exosome as a nano weapon to target the COVID-19 pandemic
YASHVI SHARMA, SUCHI GUPTA, SUJATA MOHANTY
BIOCELL, Vol.45, No.3, pp. 517-520, 2021, DOI:10.32604/biocell.2021.014621
（This article belongs to this Special Issue: Stem Cells, Protein Therapeutics, and Regenerative Medicine)
Abstract In these times of despair when a nano-sized organism, the SARS-CoV-2, has rendered the human race helpless, made the global health status decline, and drowned the world economy, a ray of hope comes from another nano-sized particle, the exosome. The potential of mesenchymal stem cells has already been established in COVID-19; however, cell-based therapy has its risks. We thereby propose cell-free therapy using stem cells-derived exosomes to fight against COVID-19, as they can be a game-changer owing to their immunomodulatory nature, which combats the cytokine storm characterizing this disease, and their practical efficiency, which will realistically aid large access to… More >

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ARTICLE

Study on the clinical significance of TRPV2 and MMP2 expressions in ovarian cancer
XIAOPANG REN, WANJIAO HAO, JIN LIU, YE LI, BING WANG, XINHUI ZU, HUILING XUE
BIOCELL, Vol.45, No.3, pp. 521-526, 2021, DOI:10.32604/biocell.2021.012137
（This article belongs to this Special Issue: Stem Cells, Protein Therapeutics, and Regenerative Medicine)
Abstract Ovarian cancer was one of the most common malignant tumors in female reproductive organs. Moreover, epithelial ovarian cancer showed the highest mortality rate in gynecological tumors, posing serious threats to women’s life and health. Transient Receptor Potential Cation Channel Subfamily V Member 2 (TRPV2) and matrix metalloproteinase-2 MMP-2 have been found to play important roles in regulating the pathogenesis of most tumors, but there were few studies exploring the relationships of TRPV2 and MMP-2 in OC. Therefore, we evaluated the expression of TRPV2 and MMP-2 proteins in cancer tissues and adjacent normal tissues of OC patients. Immunohistochemistry was used to… More >

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ARTICLE

Synergetic effects of shock waves with polydeoxyribonucleotides on rotator cuff tendon tear in a rabbit model
DONG HAN KIM, DONG RAK KWON, GI-YOUNG PARK, YONG SUK MOON
BIOCELL, Vol.45, No.3, pp. 527-536, 2021, DOI:10.32604/biocell.2021.014350
（This article belongs to this Special Issue: Stem Cells, Protein Therapeutics, and Regenerative Medicine)
Abstract This work aimed to investigate the synergetic therapeutic effects of polydeoxyribonucleotides (PDRN) combined with extracorporeal shock waves therapy (ESWT) and the effects of the therapy according to ESWT sequences on a chronic traumatic full-thickness rotator cuff tear (RCT) in rabbit models. For this purpose, thirty-two rabbits were randomly allocated into 4 groups. An excision was made to create a 5-mm sized full-thickness RCT right proximal to the insertion site on the supraspinatus. After 6 weeks, 4 different procedures (normal saline, Group 1; PDRN injection, Group 2; PDRN injection before ESWT, Group 3; PDRN injection after ESWT, Group 4) were performed.… More >

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ARTICLE

Human adipose, placenta, and umbilical cord-derived mesenchymal stem cells ameliorate imiquimod-induced psoriatic mice via reducing T cells infiltration
JIGANG LEI, ZHENYAO XU, SUKE LI, MENG LI, ZHIKAI WANG, PING LI, JING WANG, YINGLU CHEN, XIAOLE SONG, CHENGJIE REN, MEIPING SHEN, CHENGXIANG DAI
BIOCELL, Vol.45, No.3, pp. 537-546, 2021, DOI:10.32604/biocell.2021.014569
（This article belongs to this Special Issue: Stem Cells, Protein Therapeutics, and Regenerative Medicine)
Abstract Psoriasis is an autoimmune-related chronic inflammatory disease with an approximate prevalence of 2–3% around the world, involving increased keratinocyte proliferation. Indeed, Th17 cells and IL-17 play critical roles in the pathogenesis of psoriasis. The monoclonal antibodies against cytokines have been shown to have effectively immunosuppressive effects on human psoriasis. However, there are still some patients that have no response to these treatments. Some patients have even serious side-effects which may affect their life. Mesenchymal stem cells have the ability of immunosuppressive and anti-inflammatory effects, which may be an alternative therapy with more safety and efficacy for human psoriasis. Moreover, the… More >

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ARTICLE

The role of HBD-2, HBD-3, and calprotectin in the relationship between chronic periodontitis and atherosclerosis
MEHMET TASPINAR, ALIHAN BOZOGLAN, ABDULLAH SECKIN ERTUGRUL, LEVENT ELMAS
BIOCELL, Vol.44, No.3, pp. 337-344, 2020, DOI:10.32604/biocell.2020.011470
（This article belongs to this Special Issue: Stem Cells, Protein Therapeutics, and Regenerative Medicine)
Abstract This study was carried out to compare individuals diagnosed with atherosclerosis and periodontal periodontitis based on the degree of change in the human beta-defensins (HBD) HBD-2, HBD-3, and calprotectin. Atherosclerosis is the most frequently observed cardiovascular disease. Dental and periodontal infections are known to provide a considerable basis for atheroma plaque formation. The study group consists of a total number of 40 subjects, with 20 patients diagnosed with atherosclerosis and chronic periodontitis and 20 systemically healthy patients diagnosed with chronic periodontitis. Clinical periodontal and blood parameters and HBD-2, HBD-3, and calprotectin biomarkers in the gingival crevicular fluid were measured. In… More >

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ARTICLE

Enhanced osteogenic differentiation of human periodontal ligament stem cells by suberoylanilide hydroxamic acid
YUNZE XUAN, BIN JIN, SAYAN DEB DUTTA, MENGMENG LIU, ZAIXIAN SHEN, XIWEN LIU, YANG KANGJUAN, LIM KI-TAEK
BIOCELL, Vol.44, No.3, pp. 389-400, 2020, DOI:10.32604/biocell.2020.09170
（This article belongs to this Special Issue: Stem Cells, Protein Therapeutics, and Regenerative Medicine)
Abstract Periodontitis is a type of chronic inflammation in the gingival tissue caused by infectious bacteria colonizing the surface of the teeth, leading to the destruction of tooth-supporting tissues and loss of alveolar bone. Suberoylanilide hydroxamic acid (SAHA), a class of histone deacetylase (HDAC) inhibitor, has the potential to stimulate osteoblast differentiation by acetylating histone proteins, and thus suppressing the expression of adipogenic and chondrogenic genes. However, the effect of SAHA on the differentiation of human periodontal ligament stem cells (hPDLSCs) is yet to be elucidated. Herein, we investigated the effects of SAHA on in vitro proliferation and differentiation of hPDLSCs… More >

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Stem Cells, Protein Therapeutics, and Regenerative Medicine

Guest Editors

Summary

Keywords

Published Papers

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3227

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1748

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2612

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1340

Cited by

1

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2574

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1562

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2390

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1527

Cited by

2

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2293

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1679

Cited by

1

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2714

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1875

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2485

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1482

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1

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2602

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1773

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1

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