Table of Content

Open Access iconOpen Access

ARTICLE

crossmark

The role of HBD-2, HBD-3, and calprotectin in the relationship between chronic periodontitis and atherosclerosis

MEHMET TASPINAR1,2,*, ALIHAN BOZOGLAN3,4, ABDULLAH SECKIN ERTUGRUL5, LEVENT ELMAS6

1 Faculty of Medicine, Aksaray University, Aksaray, Turkey
2 Faculty of Medicine, Yuzuncu Yil University, Van, Turkey
3 Department of Periodontology, Faculty of Dentistry, Fırat University, Elazığ, Turkey
4 Department of Periodontology, Faculty of Dentistry, Yuzuncu Yil University, Van, Turkey
5 Department of Periodontology, Faculty of Dentistry, İzmir Katip Çelebi University, İzmir, Turkey 6 Faculty of Medicine, Pamukkale University, Denizli, Turkey

* Address correspondence to: Mehmet Taspinar, email

(This article belongs to the Special Issue: Stem Cells, Protein Therapeutics, and Regenerative Medicine)

BIOCELL 2020, 44(3), 337-344. https://doi.org/10.32604/biocell.2020.011470

Abstract

This study was carried out to compare individuals diagnosed with atherosclerosis and periodontal periodontitis based on the degree of change in the human beta-defensins (HBD) HBD-2, HBD-3, and calprotectin. Atherosclerosis is the most frequently observed cardiovascular disease. Dental and periodontal infections are known to provide a considerable basis for atheroma plaque formation. The study group consists of a total number of 40 subjects, with 20 patients diagnosed with atherosclerosis and chronic periodontitis and 20 systemically healthy patients diagnosed with chronic periodontitis. Clinical periodontal and blood parameters and HBD-2, HBD-3, and calprotectin biomarkers in the gingival crevicular fluid were measured. In both groups, following clinical periodontal treatment, a statistically significant decrease in white blood cells (WBC), low-density lipoproteins (LDL), fibrinogen, creatinine, and platelets (PLT), a statistically significant increase in high-density lipoproteins (HDL) in blood samples, statistically meaningful decrease in HBD-2, HBD-3, and calprotectin in the gingival crevicular fluid were achieved. Blood values and HBD-2, HBD-3, calprotectin amounts in the gingival crevicular fluid were increased significantly in the test group compared to the control group. A positive correlation was observed between decreases in HBD-2, HBD-3, calprotectin, and clinical periodontal indices. Regression in systemic inflammation was observed after clinical periodontal treatment. It is concluded that nonsurgical periodontal treatment of chronic periodontitis positively affects atherosclerosis prognosis.

Keywords


Cite This Article

APA Style
TASPINAR, M., BOZOGLAN, A., ERTUGRUL, A.S., ELMAS, L. (2020). The role of HBD-2, HBD-3, and calprotectin in the relationship between chronic periodontitis and atherosclerosis. BIOCELL, 44(3), 337-344. https://doi.org/10.32604/biocell.2020.011470
Vancouver Style
TASPINAR M, BOZOGLAN A, ERTUGRUL AS, ELMAS L. The role of HBD-2, HBD-3, and calprotectin in the relationship between chronic periodontitis and atherosclerosis. BIOCELL . 2020;44(3):337-344 https://doi.org/10.32604/biocell.2020.011470
IEEE Style
M. TASPINAR, A. BOZOGLAN, A.S. ERTUGRUL, and L. ELMAS, “The role of HBD-2, HBD-3, and calprotectin in the relationship between chronic periodontitis and atherosclerosis,” BIOCELL , vol. 44, no. 3, pp. 337-344, 2020. https://doi.org/10.32604/biocell.2020.011470

Citations




cc Copyright © 2020 The Author(s). Published by Tech Science Press.
This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
  • 2725

    View

  • 1707

    Download

  • 1

    Like

Share Link