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  • Open Access

    ARTICLE

    Increased MAD2L2 expression predicts poor clinical outcome in Colon Adenocarcinoma

    HAOTONG SUN1,2, HEYING WANG1,3, XIN LI1,2, YANJIE HAO1,2, JUN LING1,2, HUAN WANG1,2, FEIMIAO WANG1,2, FANG XU1,2,*

    BIOCELL, Vol.47, No.3, pp. 607-618, 2023, DOI:10.32604/biocell.2023.026445

    Abstract Background: Colon adenocarcinoma (COAD) is the second leading cause of cancer death worldwide thus, identification of COAD biomarkers is critical. Mitotic Arrest Deficient 2 Like 2 (MAD2L2) is a key factor in mammalian DNA damage repair and is highly expressed in many malignant tumors. This is a comprehensive study of MAD2L2 expression, its diagnostic value, prognostic analysis, potential biological function, and impact on the immune system of patients with COAD. Methods: Gene expression, clinical relevance, prognostic analysis, diagnostic value, GO/KEGG cluster analysis, data obtained from TCGA, and bioinformatics statistical analysis were performed using the R package. Immune responses to MAD2L2More >

  • Open Access

    ARTICLE

    A developed ant colony algorithm for cancer molecular subtype classification to reveal the predictive biomarker in the renal cell carcinoma

    ZEKUN XIN1,#, YUDAN MA2,#, WEIQIANG SONG3, HAO GAO3, LIJUN DONG3, BAO ZHANG1,*, ZHILONG REN3,*

    BIOCELL, Vol.47, No.3, pp. 555-567, 2023, DOI:10.32604/biocell.2023.026254

    Abstract Background: Recently, researchers have been attracted in identifying the crucial genes related to cancer, which plays important role in cancer diagnosis and treatment. However, in performing the cancer molecular subtype classification task from cancer gene expression data, it is challenging to obtain those significant genes due to the high dimensionality and high noise of data. Moreover, the existing methods always suffer from some issues such as premature convergence. Methods: To address those problems, we propose a new ant colony optimization (ACO) algorithm called DACO to classify the cancer gene expression datasets, identifying the essential genes of different diseases. In DACO,… More >

  • Open Access

    ARTICLE

    The microRNA pathway activation in insect cell model upon Autographa californica multiple nucleopolyhedrovirus infection

    QIAOJIN JIA1,2, YUEJUN FU1,*

    BIOCELL, Vol.47, No.3, pp. 627-645, 2023, DOI:10.32604/biocell.2023.026182

    Abstract Background: The immune system of insects exerts fundamentally different antiviral mechanisms than mammals. MicroRNAs (miRNAs) play vital roles in developing insect antiviral immunity. MiRNAs expression profiles of insects changed significantly during baculovirus infection. Methods: Differential expression profiles of miRNAs in Spodoptera frugiperda were monitored by next-generation sequencing (NGS) and RT-qPCR during Autographa californica multiple nucleopolyhedrovirus (AcMNPV) infection. The transcription levels of genes were detected by RT-qPCR. The 50% tissue culture infective dose (TCID50) endpoint dilution assay was used to determine the proliferation of progeny virus. Results: NGS revealed that 49 miRNAs were differentially expressed in Sf9 cells, and 10 of… More >

  • Open Access

    REVIEW

    Research progress of protein phosphatase 2A in cellular autophagy

    HONGMEI WU#, DI LI#, YUANYUAN HUANG, RUYUAN LIU, XIAONIAN ZHU*

    BIOCELL, Vol.47, No.3, pp. 485-491, 2023, DOI:10.32604/biocell.2023.026049

    Abstract Autophagy is an important metabolic process. It facilitates the recycling of intracellular substances by removing, degrading, and recycling damaged organelles, proteins, and lipids in lysosomal vacuoles and plays an important role in maintaining cellular homeostasis. Protein phosphatase 2A (PP2A) is a key serine/threonine phosphatase and one of the main cell cycle regulatory enzymes. As PP2A activity is essential for the cell, dysfunction or dysregulation of PP2A can affect various physiological processes, including autophagy. Here, we review the autophagy-related factors that target PP2A in different diseases, such as breast cancer, colorectal cancer, liver cancer, and Alzheimer’s disease, to maintain cell homeostasis… More >

  • Open Access

    ARTICLE

    MELLT3 protects against cerebral ischemia-reperfusion (I/R) injury through up-regulation of m6A modification

    JING JIN1,#, XINGHUA WANG2,#, XIAOXIAO ZHENG3, JIAHUA LAN3, LI ZHENG3, YING CAI3, HUI CHEN4, HONGWEI WANG5,*, LIFANG ZHENG6,*

    BIOCELL, Vol.47, No.3, pp. 619-626, 2023, DOI:10.32604/biocell.2023.026016

    Abstract Ischemic cerebrovascular disease is a leading cause of death globally and is often exacerbated by cerebral ischemic/reperfusion injury (CIRI). The exact mechanisms underlying I/R injury are unclear. In this study, we aimed to determine the role of m6A-modified methylase complex methyltransferase-like 3 (METTL3) in cerebral ischemia-reperfusion (I/R) injury. We found that m6A and METTL3 levels increased in OGD/RX-induced mouse astrocytes-cerebellar (MA-C) and the brain of middle cerebral artery occlusion (MCAO) model mice. METTL3 siRNA treatment reduced OGD-RX-induced MAC cell viability and proliferation, which increased with METTL3 over-expression. Flow cytometry analysis showed that silencing METTL3 significantly enhanced OGD/RX-induced MAC apoptosis, which… More >

  • Open Access

    REVIEW

    Biochemical association between the prevalence of genetic polymorphism and myocardial infarction

    MOMINA SHAHID1, KANWAL REHMAN2, MUHAMMAD SAJID HAMID AKASH1,*, SHALEEM SUHAIL1, SUMBAL RASHEED1, MUHAMMAD IMRAN3,4, MOHAMMED A. ASSIRI3,4

    BIOCELL, Vol.47, No.3, pp. 473-484, 2023, DOI:10.32604/biocell.2023.025930

    Abstract Genetic polymorphism has a vital role in the pathogenesis and development of myocardial infarction (MI). Single nucleotide polymorphism at any one of the amino acid sequences can result in a diseased state. A single gene can exhibit genetic polymorphism at more than one position giving rise to different variants. Genetic polymorphism of angiotensinogen (AGT) M235T, AGT T174M, and angiotensin-1-converting enzyme (ACE) I/D, endothelial nitric oxide synthase (eNOS), and methylenetetrahydrofolate reductase (MTHFR) can be a risk factor for MI. However, it is important to study the prevalence of genetic polymorphisms of these genes among different populations. MI is influenced by genetic… More >

  • Open Access

    REVIEW

    Research progress of TRIMs protein family in tumors

    YUANYUAN HUANG#, HONGMEI WU#, RUYUAN LIU, SONG JIN, WEILAI XIANG, CHANG YANG, LI XU, XIAONIAN ZHU*

    BIOCELL, Vol.47, No.3, pp. 445-454, 2023, DOI:10.32604/biocell.2023.025880

    Abstract The tripartite motif (TRIMs) protein family has E3 ubiquitin ligase activity among most of its members. They participate in multiple cellular processes and signaling pathways in living organisms, including cell cycle, growth, and metabolism, and mediate chromatin modification, transcriptional regulation, post-translational modification, and cellular autophagy. Previous studies have confirmed that the TRIMs protein family is involved in the development of various cancers and correlated with the prognosis of tumor patients. Here we summarize the biological roles of the TRIMs protein family in cancers. More >

  • Open Access

    ARTICLE

    SW-Net: A novel few-shot learning approach for disease subtype prediction

    YUHAN JI1, YONG LIANG1,*, ZIYI YANG2, NING AI1

    BIOCELL, Vol.47, No.3, pp. 569-579, 2023, DOI:10.32604/biocell.2023.025865

    Abstract Few-shot learning is becoming more and more popular in many fields, especially in the computer vision field. This inspires us to introduce few-shot learning to the genomic field, which faces a typical few-shot problem because some tasks only have a limited number of samples with high-dimensions. The goal of this study was to investigate the few-shot disease sub-type prediction problem and identify patient subgroups through training on small data. Accurate disease sub-type classification allows clinicians to efficiently deliver investigations and interventions in clinical practice. We propose the SW-Net, which simulates the clinical process of extracting the shared knowledge from a… More >

  • Open Access

    REVIEW

    ROS-hormone interaction in regulating integrative défense signaling of plant cell

    DURGA KORA1, ANANYA DEY1, BABITA PAL1, UTHPAL KRISHNA ROY1,2, NIVEDITA DEY1, TREESHA BHATACHARJEE1, SOUMEN BHATTACHARJEE1,*

    BIOCELL, Vol.47, No.3, pp. 503-521, 2023, DOI:10.32604/biocell.2023.025744

    Abstract The elaborate redox network of the cell, comprising of events like turnover of reactive oxygen species (ROS), redox sensing, signaling, expression of redox-sensitive genes, etc., often orchestrates with other bonafide hormonal signaling pathways through their synergistic or antagonistic action in the plant cell. The redox cue generated in plant cells under fluctuating environmental conditions can significantly influence other hormonal biosynthetic or signaling mechanisms, thereby modulating physiology towards stress acclimation and defense. There is also strong evidence of the recruitment of ROS as a ‘second messenger’ in different hormonal signaling pathways under stress. Moreover, the retrograde signaling initiated by ROS also… More >

  • Open Access

    REVIEW

    Translocation and transformation of engineered nanomaterials in plant cells and their effect on metabolism

    WEICHEN ZHAO1, PINGFAN ZHOU1, BENZHEN LOU1, YAQI JIANG1, YUANBO LI1, MINGSHU LI1, NOMAN SHAKOOR1, YUKUI RUI1,2,3,4,*

    BIOCELL, Vol.47, No.3, pp. 493-502, 2023, DOI:10.32604/biocell.2023.025740

    Abstract As the climate worsens and the demand for food grows, so does the interest in nanoagriculture. The interaction between plants and nanomaterials (NMs) has been extensively and intensively examined. However, stopping at the outcome of a phenomenon is often insufficient. Therefore, we introduce three important processes of nanoparticle-plant interactions: translocation, transformation, and plant metabolism. During the migration of nanoparticles, size and surface electrical properties are the main determining factors. Additionally, the interaction of nanoparticles with cell membranes is another key aspect of research. The transformation of nanoparticles in plants is mainly due to redox substances. The way that nanoparticles affect… More >

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