Table of Content

Biochemical and Epigenetics Changes in Health and Disease

Submission Deadline: 30 November 2022 Submit to Special Issue

Guest Editors

Prof. Dr. Ozge Çevik, Department of Medical Biochemistry, School of Medicine, Aydın Adnan Menderes University, Aydın, Turkey. E-mail:

Assoc. Prof. Dr. Ismail Sari, Department of Medical Biochemistry, School of Medicine, Nigde Omer Halisdemir University, Nigde, Turkey. E-mail:

Asst. Prof. Dr. Erkan Gumus, Department of Histology and Embryology, School of Medicine, Aydın Adnan Menderes University, Aydın, Turkey.


Health is defined as "the harmonious work of thousands of biochemical reactions and processes that occur in normal cells to maintain homeostasis." Disruption of these processes or reactions and/or failure to progress in harmony can lead to diseases. The continuity of health also depends on the unchanged expression of the genes involved in these biochemical transformations and processes, in other words, to remain the same. Although the chemical and molecular structure of DNA is understood, thanks to the findings obtained in the epigenetic field in recent years, it is understood that not everything is dependent on DNA in biological processes and diseases. Epigenetic changes that occur without causing a change in the base sequence in DNA play an essential role in regulating of the expression of a gene. Therefore, it is inevitable that epigenetic changes affect biochemical processes. Thus, epigenetic and biochemical changes are closely interrelated, and thanks to the developments in epigenetics and biochemistry in recent years, we now have more information about developmental biology and pathogenesis of many diseases.


The current special issue will focus on Biochemical and Epigenetic changes in development and diseases, therapies, and their relationship. We welcome investigators in relevant fields to contribute research articles, reviews, perspectives, and commentaries, describing recent findings which use advanced molecular biological and biochemical techniques. Potential topics include but are not limited to the followings:


-Changes in epigenetic mechanisms in development and disease and their importance

-Researches (especially pathway-based studies) that examine changes in biochemical processes in disease and development

-Studies examining the pathogenesis of diseases based on lipidomics, proteomics, and genomics approaches

-Studies revealing the connection between epigenetic mechanisms and biochemical processes in development and disease

-Studies on therapies used in the treatment of diseases


Epigenetics, Biochemical Pathway, Developmental Biology, Lipidomics, Proteomics, Genomics, Biochemical Basis Of Disease, Therapies

Published Papers

  • Open Access


    The role of 5′-adenosine monophosphate-activated protein kinase (AMPK) in skeletal muscle atrophy

    BIOCELL, Vol.47, No.2, pp. 269-281, 2023, DOI:10.32604/biocell.2023.023766
    (This article belongs to this Special Issue: Biochemical and Epigenetics Changes in Health and Disease)
    Abstract As a key coordinator of metabolism, AMP-activated protein kinase (AMPK) is vitally involved in skeletal muscle maintenance. AMPK exerts its cellular effects through its function as a serine/threonine protein kinase by regulating many downstream targets and plays important roles in the development and growth of skeletal muscle. AMPK is activated by phosphorylation and exerts its function as a kinase in many processes, including synthesis and degradation of proteins, mitochondrial biogenesis, glucose uptake, and fatty acid and cholesterol metabolism. Skeletal muscle atrophy is a result of various diseases or disorders and is characterized by a decrease in muscle mass. The pathogenesis… More >

  • Open Access


    Diagnostic and prognostic significance of the lymphocyte/C-reactive protein ratio, neutrophil/lymphocyte ratio, and D-dimer values in patients with COVID-19

    BIOCELL, Vol.46, No.12, pp. 2625-2635, 2022, DOI:10.32604/biocell.2022.023124
    (This article belongs to this Special Issue: Biochemical and Epigenetics Changes in Health and Disease)
    Abstract In this study, our aim was to examine the diagnostic and prognostic significance of lymphocyte/C-reactive protein ratio (LCR), neutrophil/lymphocyte ratio (NLR) and D-dimer parameters in COVID-19 infection. The LCR, NLR, neutrophil count, mean platelet volume (MPV), C-reactive protein (CRP), and D-dimer parameters were evaluated retrospectively. This was a retrospective cohort study with 1000 COVID-19 positive and 1000 healthy control groups, all over the age of 18 years. Odds ratio (OR) and 95% confidence interval (CI) values were calculated for each parameter found to be statistically significant in the univariate and multivariate logistic regression models. Herein, 127 (12.7%) of the COVID-19+More >

  • Open Access


    Hypoxia induced apoptosis of rat gastric mucosal cells by activating autophagy through HIF-1α/TERT/mTORC1 pathway

    BIOCELL, Vol.46, No.7, pp. 1651-1659, 2022, DOI:10.32604/biocell.2022.018559
    (This article belongs to this Special Issue: Biochemical and Epigenetics Changes in Health and Disease)
    Abstract The pathogenesis of high altitude-related gastric mucosal injury remains poorly understood, this study aimed to investigate the role of autophagy in hypoxia-induced apoptosis of rat gastric mucosal cells. Rats were randomized into four groups which were maintained at an altitude of 400 m (P) or received no treatment (H), autophagy inducer rapamycin (H+AI) or autophagy inhibitor 3-MA (H+AB) at an altitude of 4,300 m for 1, 7, 14 and 21 days, respectively, and the morphology, ultrastructure, autophagy, and apoptosis of gastric mucosal tissues were examined. Gastric mucosal epithelial cells CC-R039 were cultured under conditions of normoxia, 2% O2 (hypoxia), or… More >

  • Open Access


    Co-regulator NCOA5 and cancer

    BIOCELL, Vol.46, No.7, pp. 1643-1650, 2022, DOI:10.32604/biocell.2022.019142
    (This article belongs to this Special Issue: Biochemical and Epigenetics Changes in Health and Disease)
    Abstract NCOA5 encodes a co-regulator for estrogen receptors (ERα and ERβ), orphan nuclear receptors (REV-ERBα and REV-ERBβ) and liver X receptor. It can influence many cellular processes by either promoting or inhibiting gene expression through its two important functional motifs: LxxLL (co-activator) and ΦxxΦΦ (co-repressor). Many reports have revealed the important roles of NCOA5 in diseases, such as diabetes, reproductive defects and autoimmune disease. In this review, we focus on its function in cancers and summary the current research progresses regarding its different roles in various cancers. More >

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