Open Access

REVIEW

Protein-mediated interactions in the dynamic regulation of acute inflammation

RYAN STARK^*

Department of Pediatric Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232-9075, USA

* Corresponding Author: RYAN STARK. Email:

(This article belongs to this Special Issue: Biochemical and Epigenetics Changes in Health and Disease)

BIOCELL 2023, 47(6), 1191-1198. https://doi.org/10.32604/biocell.2023.027838

Received 18 November 2022; Accepted 09 February 2023; Issue published 19 May 2023

Abstract

Protein-mediated interactions are the fundamental mechanism through which cells regulate health and disease. These interactions require physical contact between proteins and their respective targets of interest. These targets include not only other proteins but also nucleic acids and other important molecules as well. These proteins are often involved in multibody complexes that work dynamically to regulate cellular health and function. Various techniques have been adapted to study these important interactions, such as affinity-based assays, mass spectrometry, and fluorescent detection. The application of these techniques has led to a greater understanding of how protein interactions are responsible for both the instigation and resolution of acute inflammatory diseases. These pursuits aim to provide opportunities to target specific protein interactions to alleviate acute inflammation.

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Keywords

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