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Protein-mediated interactions in the dynamic regulation of acute inflammation


Department of Pediatric Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232-9075, USA

* Corresponding Author: RYAN STARK. Email:

(This article belongs to this Special Issue: Biochemical and Epigenetics Changes in Health and Disease)

BIOCELL 2023, 47(6), 1191-1198.


Protein-mediated interactions are the fundamental mechanism through which cells regulate health and disease. These interactions require physical contact between proteins and their respective targets of interest. These targets include not only other proteins but also nucleic acids and other important molecules as well. These proteins are often involved in multibody complexes that work dynamically to regulate cellular health and function. Various techniques have been adapted to study these important interactions, such as affinity-based assays, mass spectrometry, and fluorescent detection. The application of these techniques has led to a greater understanding of how protein interactions are responsible for both the instigation and resolution of acute inflammatory diseases. These pursuits aim to provide opportunities to target specific protein interactions to alleviate acute inflammation.


Cite This Article

STARK, R. (2023). Protein-mediated interactions in the dynamic regulation of acute inflammation. BIOCELL, 47(6), 1191–1198.

This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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