Open Access
VIEWPOINT
Co-regulator NCOA5 and cancer
YUANYUAN CHEN, SHUAISHUAI CUI, YUNFEI GUO, DAHU CHEN*
School of Life Sciences, Shandong University of Technology, Zibo, 225000, China
* Corresponding Author: Dahu Chen,
(This article belongs to the Special Issue: Biochemical and Epigenetics Changes in Health and Disease)
BIOCELL 2022, 46(7), 1643-1650. https://doi.org/10.32604/biocell.2022.019142
Received 05 September 2021; Accepted 04 November 2021; Issue published 17 March 2022
Abstract
NCOA5 encodes a co-regulator for estrogen receptors (ERα and ERβ), orphan nuclear receptors (REV-ERBα
and REV-ERBβ) and liver X receptor. It can influence many cellular processes by either promoting or inhibiting gene
expression through its two important functional motifs: LxxLL (co-activator) and ΦxxΦΦ (co-repressor). Many
reports have revealed the important roles of NCOA5 in diseases, such as diabetes, reproductive defects and
autoimmune disease. In this review, we focus on its function in cancers and summary the current research progresses
regarding its different roles in various cancers.
Keywords
Cite This Article
CHEN, Y., CUI, S., GUO, Y., CHEN, D. (2022). Co-regulator NCOA5 and cancer.
BIOCELL, 46(7), 1643–1650. https://doi.org/10.32604/biocell.2022.019142