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Exosomes: Key tools for cancer liquid biopsy

ISABELLA PANFOLI1,*, MAURIZIO BRUSCHI2, GIOVANNI CANDIANO2

1 Dipartimento di Farmacia-DIFAR, Università di Genova, Genoa, 16132, Italy
2 Laboratory of Molecular Nephrology, IRCCS Istituto Giannina Gaslini, Genoa, 16147, Italy

* Corresponding Author: Isabella Panfoli, email

(This article belongs to the Special Issue: Extracellular Vesicles and Cancer)

BIOCELL 2022, 46(10), 2167-2176. https://doi.org/10.32604/biocell.2022.020154

Abstract

Precision medicine is based on the identification of biomarkers of tumor development and progression. Liquid biopsy is at the forefront of the ability to gather diagnostic and prognostic information on tumors, as it can be noninvasively performed prior or during treatment. Liquid biopsy mostly utilizes circulating tumor cells, or free DNA, but also exosomes. The latter are nanovesicles secreted by most cell types, found in any body fluid that deliver proteins, nucleic acids and lipids to nearby and distant cells with a unique homing ability. Exosomes function in signalling between the tumor microenvironment and the rest of the body, promoting metastasis, immune remodelling and drug resistance. Exosomes are emerging as a key tool in precision medicine for cancer liquid biopsy, as they efficiently preserve their biomarker cargo. Moreover, exosomes strongly resemble the parental cell, which can help in assessing the oxidative and metabolic state of the donor cell. In this respect, exosomes represent one of the most promising new tools to fight cancer. This review will discuss the clinical applications of profiling exosomal proteins and lipids by high-throughput proteomics and metabolomics, and nucleic acids by next generation sequencing, as well as how this may allow cancer diagnosis, therapy response monitoring and recurrence detection.

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APA Style
PANFOLI, I., BRUSCHI, M., CANDIANO, G. (2022). Exosomes: key tools for cancer liquid biopsy. BIOCELL, 46(10), 2167-2176. https://doi.org/10.32604/biocell.2022.020154
Vancouver Style
PANFOLI I, BRUSCHI M, CANDIANO G. Exosomes: key tools for cancer liquid biopsy. BIOCELL . 2022;46(10):2167-2176 https://doi.org/10.32604/biocell.2022.020154
IEEE Style
I. PANFOLI, M. BRUSCHI, and G. CANDIANO "Exosomes: Key tools for cancer liquid biopsy," BIOCELL , vol. 46, no. 10, pp. 2167-2176. 2022. https://doi.org/10.32604/biocell.2022.020154



cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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