CHDOpen Access

Congenital Heart Disease

ISSN:1747-079X(print)
ISSN:1747-0803(online)
Publication Frequency:Bi-monthly

  • Online
    Articles

    1693

  • on board
    editors

    48

Special Issues



About the Journal

Congenital Heart Disease is the first journal focused exclusively on the study and treatment of congenital heart defects in children and adults. It is the official journal of the Children’s Hospital of Nanjing Medical University. We are committed to publishing clinical studies, invited editorials, state-of-the-art reviews, case reports, articles focusing on the history and development of congenital heart disease, and CME material. All manuscripts (including invited) will undergo a rigorous and thorough editorial procedure to promote reliable research findings.

Indexing and Abstracting

Science Citation Index Expanded (Clarivate Analytics): 2022 Impact Factor: 0.3; Scopus CiteScore (Impact per Publication 2023): 0.4; SNIP (Source Normalized Impact per Paper 2023): 0.235; Journal Citation Report/Science Edition (JCR); etc.

  • Open Access

    EDITORIAL

    Health Systems Strengthening to Tackle the Global Burden of Pediatric and Congenital Heart Disease: A Diagonal Approach

    Congenital Heart Disease, Vol.19, No.2, pp. 131-138, 2024, DOI:10.32604/chd.2024.049814
    Abstract This article has no abstract. More >

  • Open Access

    REVIEW

    Arterial Duct Stenting Versus Modified Blalock-Taussig Shunt in Patient with Ductal-Dependent Pulmonary Circulation: Systematic Review & Meta-Analysis

    Congenital Heart Disease, Vol.19, No.2, pp. 139-156, 2024, DOI:10.32604/chd.2024.050348
    Abstract Objective: Patients with ductal-dependent pulmonary circulation require alternative blood flow to provide and maintain adequate oxygenation. Modified Blalock-Taussig Shunt (MBTS) has been the standard for providing such a result. Currently, less invasive methods such as Arterial Duct (AD) stenting have been performed as alternatives. This study aims to compare the outcome of AD stenting and MBTS. Method: Systematic research was performed in online databases using the PRISMA protocol. The outcomes measured were 30-day mortality, complication, unplanned intervention, oxygen saturation, duration of hospital, and ICU length of stay. Any comparative study provided with full text is… More >

  • Open Access

    REVIEW

    Treatment and Clinical Management of Chronic Thromboembolic Pulmonary Hypertension: An Update of Literature Review

    Congenital Heart Disease, Vol.19, No.2, pp. 157-176, 2024, DOI:10.32604/chd.2024.047930
    Abstract Chronic thromboembolic pulmonary hypertension (CTEPH) is a chronic, progressive, debilitating, and life-threatening complication of pulmonary embolism (PE). Recent technological advances have permitted various treatment options for the treatment of CTEPH, including surgery, angioplasty, and medical treatment, depending on the location and characteristics of lesions. Pulmonary endarterectomy (PEA) is the treatment of choice for CTEPH, as it offers excellent long-term outcomes and a high probability of recovery. Moreover, various medical and interventional therapies are currently being developed for patients with inoperable CTEPH. This review mainly summarizes the current treatment approaches of CTEPH, offering more options for More >

  • Open Access

    CASE REPORT

    Bicuspidization Using the Open-Sleeve Technique for Congenital Aortic Stenosis during Infancy

    Congenital Heart Disease, Vol.19, No.2, pp. 177-183, 2024, DOI:10.32604/chd.2024.050945
    Abstract Congenital aortic stenosis (cAS) frequently requires intervention during the neonatal or infantile period. However, surgical repair is challenging because of the narrow surgical space. We performed bicuspidization using the open-sleeve technique for cAS with a unicuspid aortic valve in two patients. Postoperatively, the patients were doing well without reintervention for the aortic valve for 8 and 6 years, respectively. Their aortic annular diameter increased along with somatic growth. Bicuspidization for neonates or infancy can be performed safely using the open-sleeve technique as its midterm results have been satisfactory. More >

    Graphic Abstract

    Bicuspidization Using the Open-Sleeve Technique for Congenital Aortic Stenosis during Infancy

  • Open Access

    CASE REPORT

    Stubborn Hypoxia in Neonates with D-Transposition of the Great Arteries after Arterial Switch Operation: Central Sleep Apnea as the Cause and Potential Indicator of Brain Immaturity

    Congenital Heart Disease, Vol.19, No.2, pp. 185-195, 2024, DOI:10.32604/chd.2024.048871
    Abstract D-transposition of the great arteries (d-TGA) is surgically repaired with the arterial switch operation (ASO) with excellent results, however short and long-term morbidities still develop including neurocognitive delay. Clinically significant central sleep apnea is uncommon in non-premature infants, but when present indicates immature autonomic control of respiration likely due to a neurologic disorder. We report the unanticipated finding of central sleep apnea in four-term neonates with d-TGA after uncomplicated ASO, with the short-term complication of delayed hospital discharge and long-term concerns regarding this early marker of brain immaturity and its hindrance to normal development. Within More >

  • Open Access

    ARTICLE

    High Prevalence of Anatomical Variations and Anomalies of the Coronary Arteries Detected by CT Angiography in Symptomatic Patients

    Congenital Heart Disease, Vol.19, No.2, pp. 197-206, 2024, DOI:10.32604/chd.2024.049401
    Abstract Objective: Coronary artery anatomical variations and anomalies are an important topic due to their potential clinical manifestations. This study aims to investigate the prevalence of coronary artery anatomical variations and anomalies in symptomatic patients with coronary computed tomography angiography (CCTA). Methods: This is a retrospective study that included all symptomatic patients who had CCTA in a tertiary care hospital in Saudi Arabia during a period of seven years. Results: The total number of included patients was 507 (60% males) with a mean age of 57.4 years. Approximately 41% had luminal stenoses, averaging 49.7%. The total number… More >

  • Open Access

    ARTICLE

    Failure to Rescue as a Quality Metric in Congenital Heart Surgeries in a High-Complexity Service Provider Institution Located in a Middle-Income Country

    Congenital Heart Disease, Vol.19, No.2, pp. 207-218, 2024, DOI:10.32604/chd.2024.044244
    Abstract Background: Failure to rescue has been an effective quality metric in congenital heart surgery. Conversely, morbidity and mortality depend greatly on non-modifiable individual factors and have a weak correlation with better-quality performance. We aim to measure the complications, mortality, and risk factors in pediatric patients undergoing congenital heart surgery in a high-complexity institution located in a middle-income country and compare it with other institutions that have conducted a similar study. Methods: A retrospective observational study was conducted in a high-complexity service provider institution, in Cali, Colombia. All pediatric patients undergoing any congenital heart surgery between… More >

  • Open Access

    REVIEW

    Machine Learning-Based Intelligent Auscultation Techniques in Congenital Heart Disease: Application and Development

    Congenital Heart Disease, Vol.19, No.2, pp. 219-231, 2024, DOI:10.32604/chd.2024.048314
    Abstract Congenital heart disease (CHD), the most prevalent congenital ailment, has seen advancements in the “dual indicator” screening program. This facilitates the early-stage diagnosis and treatment of children with CHD, subsequently enhancing their survival rates. While cardiac auscultation offers an objective reflection of cardiac abnormalities and function, its evaluation is significantly influenced by personal experience and external factors, rendering it susceptible to misdiagnosis and omission. In recent years, continuous progress in artificial intelligence (AI) has enabled the digital acquisition, storage, and analysis of heart sound signals, paving the way for intelligent CHD auscultation-assisted diagnostic technology. Although More >

    Graphic Abstract

    Machine Learning-Based Intelligent Auscultation Techniques in Congenital Heart Disease: Application and Development

  • Open Access

    ARTICLE

    Single-Nucleus RNA Sequencing Reveals Cardiac Macrophage Landscape in Hypoplastic Left Heart Syndrome

    Congenital Heart Disease, Vol.19, No.2, pp. 233-246, 2024, DOI:10.32604/chd.2024.050231
    Abstract Background: Hypoplastic left heart syndrome (HLHS) is one of the most challenging congenital heart diseases in clinical treatment. In cardiac tissues, resident macrophages fulfill critical functions in maintaining a stable cardiac state and have strong regenerative capacity and organ specificity. However, the molecular mechanisms of macrophages in HLHS remained unclear. Methods: Single-nucleus RNA sequencing (snRNA-seq) data of HLHS and healthy control (donors) samples obtained from the Gene Expression Omnibus (GEO) database were normalized and clustered using the Seurat package. The “FindMarkers” function was used to screen differentially expressed genes (DEGs) between the HLHS and donor… More >

    Graphic Abstract

    Single-Nucleus RNA Sequencing Reveals Cardiac Macrophage Landscape in Hypoplastic Left Heart Syndrome

  • Open Access

    ARTICLE

    DNA Methylation Variation Is Identified in Monozygotic Twins Discordant for Congenital Heart Diseases

    Congenital Heart Disease, Vol.19, No.2, pp. 247-256, 2024, DOI:10.32604/chd.2024.052583
    Abstract Aims: Multiple genes and environmental factors are known to be involved in congenital heart disease (CHD), but epigenetic variation has received little attention. Monozygotic (MZ) twins with CHD provide a unique model for exploring this phenomenon. In order to investigate the potential role of Deoxyribonucleic Acid (DNA) methylation in CHD pathogenesis, the present study examined DNA methylation variation in MZ twins discordant for CHD, especially ventricular septal defect (VSD). Methods and Results: Using genome-wide DNA methylation profiles, we identified 4004 differentially methylated regions (DMRs) in 18 MZ twin pairs discordant for CHD, and 2826 genes were… More >

    Graphic Abstract

    DNA Methylation Variation Is Identified in Monozygotic Twins Discordant for Congenital Heart Diseases

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