Table of Content
- Vol.18, No.1, 2023
- Vol.18, No.2, 2023
- Vol.18, No.3, 2023
- Vol.18, No.4, 2023
- Vol.18, No.5, 2023
- Vol.18, No.6, 2023
- Vol.17, No.1, 2022
- Vol.17, No.2, 2022
- Vol.17, No.3, 2022
- Vol.17, No.4, 2022
- Vol.17, No.5, 2022
- Vol.17, No.6, 2022
- Vol.16, No.1, 2021
- Vol.16, No.2, 2021
- Vol.16, No.3, 2021
- Vol.16, No.4, 2021
- Vol.16, No.5, 2021
- Vol.16, No.6, 2021
- Vol.15, No.1, 2020
- Vol.15, No.2, 2020
- Vol.15, No.3, 2020
- Vol.15, No.4, 2020
- Vol.15, No.5, 2020
- Vol.15, No.6, 2020
- Vol.14, No.1, 2019
- Vol.14, No.2, 2019
- Vol.14, No.3, 2019
- Vol.14, No.4, 2019
- Vol.14, No.5, 2019
- Vol.14, No.6, 2019
- Vol.13, No.1, 2018
- Vol.13, No.2, 2018
- Vol.13, No.3, 2018
- Vol.13, No.4, 2018
- Vol.13, No.5, 2018
- Vol.13, No.6, 2018
- Vol.12, No.1, 2017
- Vol.12, No.2, 2017
- Vol.12, No.3, 2017
- Vol.12, No.4, 2017
- Vol.12, No.5, 2017
- Vol.12, No.6, 2017
About the Journal
Congenital Heart Disease is the first journal focused exclusively on the study and treatment of congenital heart defects in children and adults. It is the official journal of the Children’s Hospital of Nanjing Medical University. We are committed to publishing clinical studies, invited editorials, state-of-the-art reviews, case reports, articles focusing on the history and development of congenital heart disease, and CME material. All manuscripts (including invited) will undergo a rigorous and thorough editorial procedure to promote reliable research findings.
Indexing and Abstracting
Science Citation Index Expanded (Clarivate Analytics): 2023 Impact Factor: 0.3; Scopus CiteScore (Impact per Publication 2023): 0.4; SNIP (Source Normalized Impact per Paper 2023): 0.235; Journal Citation Report/Science Edition (JCR); etc.
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Open Access
ARTICLE
The Impact of a Prior Norwood Procedure on Cardiac Transplantation in Failed Fontan Physiology
Congenital Heart Disease, Vol.19, No.3, pp. 257-266, 2024, DOI:10.32604/chd.2024.052108 - 26 July 2024
Abstract Objective: The objective of this study was to compare cardiac transplant operative and postoperative courses of patients with failed Fontan physiology who were initially palliated with a Norwood (FFN) to those without a prior Norwood (FF). Methods: A single-institution retrospective review of all patients with Fontan failure who underwent cardiac transplantation from 2003–2021 was completed—22 underwent prior Norwood (FFN) and 11 did not (FF). Descriptive and inferential statistics were calculated for operative course and patient outcomes. Results: The operative course of the FFN cohort appeared to be more complex (not statistically significant, but clinically relevant)—this group… More >
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Open Access
CASE REPORT
Fate of Right Coronary Artery Occlusion after a Surgically Repaired Aorto-Ventricular Tunnel in a Neonate
Congenital Heart Disease, Vol.19, No.3, pp. 267-273, 2024, DOI:10.32604/chd.2024.051642 - 26 July 2024
Abstract The aorto-ventricular tunnel is a rare congenital cardiac anomaly. We present a case of aorto-ventricular tunnel diagnosed via fetal echocardiography. Emergency surgery was performed on the 2nd day of life to close the tunnel, located just in front of the right coronary ostium, due to the patient’s unstable health condition. The postoperative period revealed complete occlusion of the right coronary artery. Due to the patient’s stability, we opted not to reintervene on the right coronary artery. The patient fully recovered without the need for further coronary intervention. In cases of patients with an aorto-ventricular tunnel More >
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Open Access
CASE REPORT
Case Report: Surgical Correction of Transposition of the Great Arteries with Aortopulmonary Window
Congenital Heart Disease, Vol.19, No.3, pp. 275-278, 2024, DOI:10.32604/chd.2024.051370 - 26 July 2024
Abstract Introduction: Transposition of the great arteries (TGA) with aortopulmonary window is a rare type of congenital heart disease with limited experience. We reported a neonate aged 25 days receiving the arterial switch operation and assisted with extracorporeal membrane oxygenation. Conclusion: TGA with aortopulmonary window can be safely correctly with the arterial switch operation. More >
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Open Access
ARTICLE
White Matter Lesions in Young-Middle Aged Migraineurs with Patent Foreman Ovale: A Case-Control Study
Congenital Heart Disease, Vol.19, No.3, pp. 279-291, 2024, DOI:10.32604/chd.2024.051190 - 26 July 2024
Abstract Background: White matter lesion (WML) is common in aging brain and is associated with cognitive impairment and dementia. However, recent studies reported an association between patent foramen ovale (PFO) and WML in migraineurs, especially in young, middle-aged migraineurs. Our retrospective, case-control study aims to describe the clinical characteristics of WML in this population and to explore potential risk factors. Methods: 226 patients with migraine and PFO were consecutively initially screened. Relevant factors were selected by the least absolute shrinkage and selection operator (LASSO) regression and multivariable logistic regression model. A Nomogram was employed to visualize… More >
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Open Access
ARTICLE
Transcatheter Closure of Postoperative Residual Atrial or Ventricular Septal Shunts in Patients with Congenital Heart Disease
Congenital Heart Disease, Vol.19, No.3, pp. 293-303, 2024, DOI:10.32604/chd.2024.051427 - 26 July 2024
Abstract Background: Transcatheter closure (TCC) has emerged as the preferred treatment for selected congenital heart disease (CHD). While TCC offers benefits for patients with postoperative residual shunts, understanding its mid- and long-term efficacy and safety remains crucial. Objective: This study aims to assess the mid- and long-term safety and efficacy of TCC for patients with residual atrial or ventricular septal shunts following CHD correction. Methods: In this consecutive retrospective study, we enrolled 35 patients with residual shunt who underwent TCC or surgical repair of CHD between June 2011 to October 2022. TCC candidacy was determined based on… More >
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Open Access
REVIEW
Z-Score in Fetal Echocardiography–Is there Still Room for New Studies?
Congenital Heart Disease, Vol.19, No.3, pp. 305-314, 2024, DOI:10.32604/chd.2024.053484 - 26 July 2024
Abstract Congenital heart disease (CHD) is the most common type of birth defect, representing a significant cause of perinatal morbidity and mortality. Early diagnosis of such anomalies is crucial for improving outcomes. Current protocols recommend a qualitative assessment of cardiac structures using two-dimensional ultrasound (2DUS) and color Doppler imaging. In cases of suspected abnormalities, quantitative assessments through cardiac structure measurements and reference curves can aid in accurate diagnosis. Similar to centiles widely employed in obstetrics, Z-scores provide more precise quantification of various cardiac structures, particularly at the extremes of the curve. While the development of reference More >
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Open Access
ARTICLE
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Open Access
ARTICLE
Risk Stratification and Prognosis of Pulmonary Arterial Hypertension Associated with Congenital Heart Disease
Congenital Heart Disease, Vol.19, No.3, pp. 325-339, 2024, DOI:10.32604/chd.2024.052267 - 26 July 2024
(This article belongs to the Special Issue: Interventional therapy of congenital heart disease: past, now, and future)
Abstract Background: Current guidelines for managing pulmonary arterial hypertension (PAH) recommend a risk stratification approach. However, the applicability and accuracy of these strategies for PAH associated with congenital heart disease (PAH-CHD) require further validation. This study aims to validate the reliability and predictive accuracy of a simplified stratification strategy for PAH-CHD patients over a three-year follow-up. Additionally, new prognostic variables are identified and novel risk stratification methods are developed for assessing and managing PAH-CHD patients. Methods: This retrospective study included 126 PAH-CHD patients. Clinical and biochemical variables across risk groups were assessed using Kruskal-Wallis and Fisher’s… More >
Graphic Abstract
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Open Access
ARTICLE
Immediate and Long-Term Results of Transcatheter Closure of Patent Ductus Arteriosus—Comparison of Two Decades before and after Change in Antibiotic Infective Endocarditis Prophylaxis Guidelines
Congenital Heart Disease, Vol.17, No.2, pp. 215-230, 2022, DOI:10.32604/CHD.2021.017232
Abstract Objectives: To determine immediate and long-term follow-up of transcatheter closure of patent ductus arteriosus
(PDA) in children. Background: National antibiotic prophylaxis (AP) guideline for infective endocarditis changed after 2009, the effect on practice of PDA closure is unknown. Methods: Observational single center study
analyzing follow-up of PDA closure comparing two time periods before (2002–2009) and after (2010–2019)
changes in AP guideline. Results: 332 patients (68.1% female), median (interquartile range) age 3.0 years
(1.5–5.7) and body weight 14.0 kg (10.0–19.3), were enrolled. PDA morphology was conical type A (50.3%), window type B (1.2%), tubular type C (40.1%), complex type… More >
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Open Access
ARTICLE
Quality of Life in Congenital Heart Disease Patients According to Their Anatomical and Physiological Classification
Congenital Heart Disease, Vol.18, No.2, pp. 197-206, 2023, DOI:10.32604/CHD.2021.013308
Abstract Background: Living well is as important as living longer. The objective of this study is to assess quality of life
(QoL) in congenital heart disease (CHD) according to current AHA/ACC anatomical and physiological classifi-
cation. Methods: Cross-sectional study examining the World Health Organization QoL Bref questionnaire
(WHOQoL-Bref) in consecutive outpatient CHD patients from a single unit. Results: 191 CHD patients were
studied. Median age was 28 ± 13 years and 59% were male. 44 (23%), 115 (60%) and 33 (17%) CHD patients
showed mild, moderate and great anatomical defects respectively while 69 (36%) patients were in physiological… More >
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Open Access
ARTICLE
Modification of Serum Galectin-3 and Reversal of Cardiac Remodeling Following Pediatric Transcatheter Atrial Septal Defect Closure
Congenital Heart Disease, Vol.17, No.2, pp. 173-185, 2022, DOI:10.32604/CHD.2021.016987
Abstract Objectives: We aimed to evaluate the effect of percutaneous atrial septal defect (ASD) closure in children using
right heart indices and serum galectin-3 (Gal-3), as potential biomarkers of right heart remodeling. Methods: This
case–control prospective study included 40 children with ASD and 25 control subjects. An echocardiographic evaluation was performed before the procedure, as well as 24 h, 1 month, and 6 months after intervention. Serum
Gal-3 was measured before, and 1 month after the procedure. Results: Serum Gal-3 concentration, right atrial
(RA) dimensions, right ventricular (RV) dimensions, indexed RA area, and right index of myocardial
performance… More >
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Open Access
ARTICLE
The Glenn Shunt Revisited, A Single Center Registry in Ain Shams University Cardiology Department
Congenital Heart Disease, Vol.17, No.1, pp. 71-85, 2022, DOI:10.32604/CHD.2022.018372
Abstract Background: Bidirectional Glenn shunts have long been available as palliative procedures for patients with single ventricle physiology that is, patients unsuitable for biventricular repair. In our country they are performed at an older age than that recommended by the literature. So, we aim to assess post bidirectional Glenn shunt patients to detect the presence of any complications and to evaluate their functional capacity. Methods: This was a descriptive study that included all patients who underwent a bidirectional Glenn shunt and were referred for follow up in Ain shams university hospitals. History taking including NYHA class and… More >
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Open Access
ARTICLE
Characteristics of In-Hospital Patients with Congenital Heart Disease Requiring Rapid Response System Activations: A Japanese Database Study
Congenital Heart Disease, Vol.17, No.1, pp. 31-43, 2022, DOI:10.32604/CHD.2022.017407
Abstract Objectives: This study aimed to study the characteristics of in-hospital deterioration in patients with congenital heart
disease who required rapid response system activation and identify risk factors associated with 1-month mortality.
Methods: We retrospectively analysed data from a Japanese rapid response system registry with 35 participating hospitals. We included consecutive patients with congenital heart disease who required rapid response system activation
between January 2014 and March 2018. Logistic regression analyses were performed to examine the associations
between 1-month mortality and other patient-specific variables. Results: Among 9,607 patients for whom the rapid
response system was activated, only 82… More >
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Open Access
REVIEW
The Relationship between T-Wave Alternans and Adverse Cardiac Events in Patients with Congenital Long QT Syndrome: A Systematic Review and Meta-Analysis
Congenital Heart Disease, Vol.17, No.5, pp. 557-567, 2022, DOI:10.32604/CHD.2021.017292
Abstract Background: T-wave alternans (TWA) is a risk factor of ventricular arrhythmias or sudden cardiac death (SCD)
in patients with ischemic cardiomyopathy. Nevertheless, the relationship between TWA and adverse cardiac
events (ACE) in patients with congenital long QT syndrome (LQT) remains controversial. Methods: A systematic
electronic search of PubMed, Embase and the Cochrane Library was conducted from database inception dates to
28 April 2021 and assessed the relationship between TWA and ACE in patients with LQTS. Sub-group analysis
evaluated the association between microvolt TWA (MTWA) and ACE in different monitoring models and ECGlead numbers. Results: A pooled analysis… More >
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Open Access
REVIEW
Prevalence of Bicuspid Aortic Valve in Turner Syndrome Patients Receiving Cardiac MRI and CT: A Meta-Analysis
Congenital Heart Disease, Vol.17, No.2, pp. 129-141, 2022, DOI:10.32604/CHD.2022.018300
Abstract Turner syndrome (TS) is a rare disorder affecting 25–50 in 100000 female newborns. Bicuspid aortic valve (BAV)
is assumed to be the most common congenital heart defect (CHD) in TS. In literature, reported BAV prevalence in
TS ranges between 14% and 34%. The specific BAV prevalence in TS is still unknown. The aim of this study was to
give a more precise estimation of BAV prevalence in TS by conducting a meta-analysis of TS-studies, which
detected BAV by either cardiac magnetic resonance imaging (MRI) or cardiac computed tomography (CT).
We searched PubMed, Cochrane Library, and… More >
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Open Access
ARTICLE
Preoperative Feeding in Single Ventricle Neonates is Predictive of Shorter Time to Goal Feed
Congenital Heart Disease, Vol.17, No.5, pp. 505-518, 2022, DOI:10.32604/chd.2022.021571
Abstract Background: Patients with single ventricle anatomy are at increased risk of growth failure and malnutrition.
Amongst cardiac centers, there is little standardization of feeding practices in this complex population. We
hypothesized that initiation of our center’s preoperative feeding protocol would result in decreased gastrostomy
tube (G-tube) use, decreased length of stay and would not result in increased Necrotizing Enterocolitis (NEC)
rates. Methods: A single institution review of 52 patients who had undergone stage I single ventricle palliative
repair was performed. Patient diagnoses were hypoplastic left heart syndrome (39%), atrioventricular canal
(15%), and other (46%). Postoperative parameters such… More >
Graphic Abstract
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Open Access
ARTICLE
Pulmonary Perfusion Asymmetry in Patients after Repair of Tetralogy of Fallot: A 4D Flow MRI-Based Study
Congenital Heart Disease, Vol.17, No.2, pp. 117-128, 2022, DOI:10.32604/chd.2022.018779
Abstract Background: Repaired Tetralogy of Fallot (rTOF) patients may have residual lesions such as main (MPA) and branch pulmonary artery stenosis (BPAS). While MPA stenosis is well studied, few data are available on BPAS in rTOF. We aimed to describe pulmonary perfusion in a large paediatric cohort of rTOF and its impact on right ventricular and outflow-tract hemodynamics using 4D flow CMR. Methods: 130 consecutive patients (mean age at CMR 14.3 ± 4.6 years) were retrospectively reviewed. 96 patients had transannular patch without valve preservation while 34 patients had conserved annulus or valved conduit. A pulmonary blood flow ratio… More >
Graphic Abstract
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Open Access
REVIEW
Ductus Arteriosus Stent Compared with Surgical Shunt for Infants with Ductal-Dependent Pulmonary Blood Flow: A Systematic Review and Meta-Analysis
Congenital Heart Disease, Vol.17, No.1, pp. 45-60, 2022, DOI:10.32604/CHD.2022.016332
Abstract The aim of this study was to perform a systematic review and meta-analysis to evaluate the safety and efficacy of
ductus arteriosus stent (DAS) compared with surgical systemic-pulmonary artery shunt (SPS) in patients with
ductal-dependent pulmonary blood flow. A literature search was conducted in PubMed, Embase, and the
Cochrane Library databases from their inception to December 2020. Two reviewers independently screened
the articles, evaluated the quality of the articles, and collected the data. Meta-analyses were conducted using fixed
and random effects models. We used the I-square (I2
) test to examine heterogeneity and the funnel plot… More >
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Open Access
ARTICLE
Surgical Correction of Coronary Artery Ectasia Combining Congenital Coronary Artery Fistula
Congenital Heart Disease, Vol.16, No.1, pp. 95-106, 2021, DOI:10.32604/CHD.2021.014276
Abstract Background: Coronary artery ectasia (CAE) complicated with concomitant congenital coronary artery fistula (CCAF) is rare. This study characterizes the clinical characteristics of CAE combining CCAF, and reports a single-institution experience with surgical correction of CAE combining CCAF. Methods: A total of 24 symptomatic patients (8 males, median 52.5 years old) who underwent surgical correction of CAE combining CCAF in this center were reviewed. Based on the size of ectatic segment, the CAE were classified as a giant CAE (>20 mm, n = 14) and a non-giant CAE (≤20 mm, n = 10). Individualized surgical approaches were… More >
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Open Access
ARTICLE
Kabuki-Syndrome and Congenital Heart Disease—A Twenty-Year Institutional Experience
Congenital Heart Disease, Vol.16, No.2, pp. 171-181, 2021, DOI:10.32604/CHD.2021.014409
Abstract Background: Patients with genetic syndromes who undergo surgery to correct congenital heart defects can be at risk for increased morbidity or mortality. Surgical outcomes and postoperative courses following congenital heart surgery in patients with Kabuki-Syndrome (KS) have not been well studied. Objectives: The purpose of this study was to describe the postoperative courses and associated outcomes in the largest set of KS patients undergoing congenital heart surgery to date. Methods: Patients with a confirmed molecular diagnosis of KS and a diagnosis of a CHD admitted to Texas Children’s Hospital between January 1, 2000 and January 1, 2020… More >
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Open Access
REVIEW
Important Newborn Cardiac Diagnostic Dilemmas for the Neonatologist and Cardiologist–A Clinical Perspective
Congenital Heart Disease, Vol.16, No.2, pp. 189-196, 2021, DOI:10.32604/CHD.2021.014903
Abstract Most congenital heart disease (CHD) is readily recognisable in the newborn. Forewarned by previous fetal scanning, the presence of a murmur, tachypnoea, cyanosis and/or differential pulses and saturations all point to a cardiac abnormality. Yet serious heart disease may be missed on a fetal scan. There may be no murmur or clinical cyanosis, and tachypneoa may be attributed to non-cardiac causes. Tachypnoea on day 1 is usually non-cardiac except arising from ventricular failure or a large systemic arteriovenous fistula. A patent ductus arteriosus (PDA) may support either pulmonary or systemic duct dependent circulations. The initially… More >
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Open Access
ARTICLE
Selexipag as Add-on Therapy for Patients with Pulmonary Arterial Hypertension Associated with Congenital Heart Disease: A Single-Center Retrospective Study
Congenital Heart Disease, Vol.16, No.3, pp. 233-244, 2021, DOI:10.32604/CHD.2021.014272
Abstract Purpose: This study examined the efficacy and safety of selexipag in treating pulmonary arterial hypertension (PAH) associated with congenital heart disease (CHD). Materials and Methods: We conducted a retrospective study of patients with CHD-associated PAH, treated with selexipag since December 2017. Thirteen adult patients (mean age, 45.4 years; women, 77%) were treated with selexipag as add-on therapy. Baseline characteristics, World Health Organization functional class, 6-minute walking distance (6MWD) test results, N-terminal pro-B-type natriuretic peptide levels, echocardiographic data, and incidence of side effects were assessed. Results: The majority of patients (12/13, 92.3%) experienced more than one treatment-associated complication;… More >
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Open Access
ARTICLE
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Open Access
CASE REPORT
Management of “Wall to Wall Heart” in a Transient Neonatal Tricuspid Regurgitation
Congenital Heart Disease, Vol.16, No.3, pp. 205-210, 2021, DOI:10.32604/CHD.2021.015371
Abstract We present a case of a one-day-old newborn, without prenatal diagnosis, referred to our cardiologic intensive care unit in critical condition presenting sub-cyanosis and peripheral oxygen saturation of 80%. Echocardiography diagnosis was tricuspid valve dysplasia with severe regurgitation, functional pulmonary valve atresia with intact ventricular septum and reversal flow in the large patent ductus arteriosus (PDA). Chest X-ray showed severe cardiomegaly and wall to wall heart. Prostaglandin E1 infusion was started once after birth. After few days, clinical conditions progressively worsened because of right heart failure; a first pharmacological approach to close PDA failed and More >
Copyright © 2024 The Author(s). Published by Tech Science Press.