Home / Journals / CHD / Vol.16, No.6, 2021
  • Open Access

    ARTICLE

    Noninherited Factors in Fetal Congenital Heart Diseases Based on Bayesian Network: A Large Multicenter Study

    Yanping Ruan1,#, Xiangyu Liu2,#, Haogang Zhu3,*, Yijie Lu3, Xiaowei Liu1, Jiancheng Han1, Lin Sun1, Ye Zhang1, Xiaoyan Gu1, Ying Zhao1, Lei Li2, Suzhen Ran4, Jingli Chen5, Qiong Yu6, Yan Xu7, Hongmei Xia8, Yihua He1,*
    Congenital Heart Disease, Vol.16, No.6, pp. 529-549, 2021, DOI:10.32604/CHD.2021.015862
    Abstract Background: Current studies have confirmed that fetal congenital heart diseases (CHDs) are caused by various factors. However, the quantitative risk of CHD is not clear given the combined effects of multiple factors. Objective: This cross-sectional study aimed to detect associated factors of fetal CHD using a Bayesian network in a large sample and quantitatively analyze relative risk ratios (RRs). Methods: Pregnant women who underwent fetal echocardiography (N = 16,086 including 3,312 with CHD fetuses) were analyzed. Twenty-six maternal and fetal factors were obtained. A Bayesian network is constructed based on all variables through structural learning and parameter learning methods to… More >

  • Open Access

    ARTICLE

    The Impact of a Bicuspid Aortic Valve on Aortic Geometry and Function in Patients with Aortic Coarctation: A Comprehensive CMR Study

    Laura Schweikert1, Dominik Gabbert1, Sylvia Krupickova2, Inga Voges1,*
    Congenital Heart Disease, Vol.16, No.6, pp. 551-560, 2021, DOI:10.32604/CHD.2021.016635
    Abstract Background: An isolated bicuspid aortic valve (BAV) is associated with structural and functional abnormalities of the aorta and the left ventricle (LV). Although ~50% of patients with aortic coarctation (CoA) have a BAV, less is known about its impact on LV function and aortic geometry and function in CoA patients. In this cardiovascular magnetic resonance imaging (CMR) study, we analysed markers of LV and aortic function as well as aortic geometry in a large cohort of CoA patients with a BAV and compared them with CoA patients with a tricuspid aortic valve (TAV). Methods: We included 48 patients with a… More >

  • Open Access

    ARTICLE

    3D Non-Fluoroscopic Cryoablation of Right-Sided Accessory Pathways in Children: Monocentric Study and Literature Review

    Fabrizio Drago*, Irma Battipaglia, Pietro Paolo Tamborrino, Luigina Porco, Camilla Calvieri, Mario Salvatore Russo, Vincenzo Pazzano, Romolo Remoli, Massimo Stefano Silvetti
    Congenital Heart Disease, Vol.16, No.6, pp. 561-572, 2021, DOI:10.32604/CHD.2021.016623
    Abstract Background: Cryoablation of accessory pathways (APs) is effective and very safe in children, as previously reported by our group. The aim of this retrospective study was to evaluate the current efficacy of 3D non-fluoroscopic cryoablation of right sided APs in children, comparing results obtained with the Ensite VelocityTM and the more recent Ensite PrecisionTM 3D mapping systems. Methods and Results: From January 2016 to December 2019, 102 pediatric patients [mean age 12.5 ± 2.8, 62 males (61% of total cohort)] with right APs underwent 3D non-fluoroscopic transcatheter cryoablation at our Institution. Fifteen (14.7%) patients had previously undergone catheter ablation. Acute… More >

  • Open Access

    ARTICLE

    Epicardial Versus Endocardial Pacemakers in the Pediatric Population: A Comparative Inquiry

    Mohammadrafie Khorgami1, Ali Sadeghpour Tabaei2,*, Elio Caruso3,*, Silvia Farruggio3, Negar Omidi4, Maryam Moradian1, Behzad Mohammadpour Ahranjani5, Zahra Khajali6 and Rahele Zamani1
    Congenital Heart Disease, Vol.16, No.6, pp. 573-584, 2021, DOI:10.32604/CHD.2021.016271
    Abstract Background: Most children in need of cardiac pacemakers remain dependent on the function of the permanent from childhood to adulthood. We sought to evaluate and compare the function between epicardial and endocardial pacemakers in pediatric groups with different conditions. Methods: Between 2012 and 2018, this single-canter study evaluated 44 pediatric patients with indications for epicardial or endocardial pacemakers. Results: The 2 groups, at a median age of 5 (0.1–16) years, were compared concerning the characteristics of the leads used (n = 80: bipolar, unipolar, steroid-eluting, and non–steroid-eluting), survival data, and complications. The reason for pacemaker implantation was congenital complete heart… More >

  • Open Access

    ARTICLE

    What Is the Relation between Aerobic Capacity and Physical Activity Level in Adults with Congenital Heart Disease?

    Kelly Ferri1,*, Maite Doñate2,3, Mireia Parra2,3, Guillermo R. Oviedo1, Myriam Guerra-Balic1, Laia Rojano-Doñate4, Nicole Blackburn5, Ricard Serra-Grima2,3
    Congenital Heart Disease, Vol.16, No.6, pp. 585-595, 2021, DOI:10.32604/CHD.2021.016189
    Abstract Background: Aerobic capacity (AC) in adults with congenital heart disease (CHD) is often reduced, mainly due to low confidence levels towards physical activity (PA). The main objective of this study was to estimate the association between PA level and AC (measured as peak of oxygen consumption, VO2peak) in adults with CHD. Methods: A total of 183 individuals (83 women and 100 men; mean (SD) age 36.9 (11.0) years old) from Vall d’Hebron Hospital, Barcelona-Spain in 2019, participated in this cross-sectional study. The AC was assessed by cardiopulmonary exercise testing (CPET) using a treadmill ramp protocol. Considering values of metabolic equivalent… More >

  • Open Access

    ARTICLE

    Cardiopulmonary Response to Exercise at High Altitude in Adolescents with Congenital Heart Disease

    Lukas Minder1, Markus Schwerzmann1,2, Thomas Radtke1,3, Hugo Saner1, Prisca Eser1, Matthias Wilhelm1, Jean-Paul Schmid1,4,*
    Congenital Heart Disease, Vol.16, No.6, pp. 597-608, 2021, DOI:10.32604/CHD.2021.016031
    Abstract Objective: To extend our knowledge on tolerance of acute high-altitude exposure and hemodynamic response to exercise in adolescents with congenital heart disease (AscCHD) without meaningful clinical or functional restriction. Methods: A symptom limited cardiopulmonary exercise stress test and a non-invasive cardiac output measurement during steady state exercise were performed at 540 m and at 3454 m a.s.l. Symptoms of acute mountain sickness were noted. Results: We recruited 21 healthy controls and 16 AscCHD (59% male, mean age 14.7 ± 1.1 years). Three subjects (2 controls, 1 AscCHD) presented light symptoms of acute mountain sickness (dizziness and headache). During the symptom… More >

  • Open Access

    REVIEW

    Effect of Cardioplegia for Myocardial Protection in Pediatric Cardiac Surgery: A Network Meta-Analysis

    Ke Zhou1, Dongyu Li1, Xintong Zhang2, Wensheng Wang1, Shusen Li1, Guang Song2,*
    Congenital Heart Disease, Vol.16, No.6, pp. 609-645, 2021, DOI:10.32604/CHD.2021.016396
    Abstract Cardioplegia has been widely used to reduce myocardial injury during pediatric cardiac surgery; however, which cardioplegia solution has the best protective effect has not been established. Thus, we compared the myocardial protective effects of different cardioplegia solutions used in pediatric cardiac surgery. Seven databases were searched to identify the relevant randomized controlled trials. A network meta-analysis with a Bayesian framework was conducted. The outcomes included the following biochemical and clinical outcomes: serum concentrations of the creatine kinase-myocardial band at 6 h postoperatively; cardiac troponin I (cTnI) at 4, 12, and 24 h postoperatively; spontaneous beating after declamping; postoperative arrhythmias; inotropic… More >

  • Open Access

    CASE REPORT

    Combined Surgical Treatment of Atherosclerotic Coronary Artery Disease and Moderate Aortic Valve Stenosis in Patient with Concomitant Lipton’s R-III Type of Single Coronary Artery Anomaly

    Milica Karadzic Kocica1, Hristina Ugrinovic1, Dejan Lazovic2, Nemanja Karamarkovic2, Milos Grujic2, Borivoje Lukic3, Oliver Radmili3, Vladimir Cvetic3, Mladen Kocica2,*
    Congenital Heart Disease, Vol.16, No.6, pp. 647-653, 2021, DOI:10.32604/CHD.2021.016923
    Abstract A single coronary artery is a very rare condition, commonly associated with other congenital anomalies. It could be generally considered as neither benign nor malignant form of congenital coronary artery anomalies since its pathophysiological and clinical implications grossly depend on different anatomical patterns defined by the site of origin and distribution of the branches. By presenting the patient who underwent successful coronary artery bypass grafting and aortic valve replacement surgery in a presence of isolated single coronary artery, we intend to emphasize natural and procedural risks and distinguish casual from causal in this extremely rare clinical and surgical scenario. More >

  • Open Access

    ARTICLE

    Clinical Effect of an Improved Post-Operative Feeding Protocol “in Transition” Infants of Congenital Heart Disease with Pulmonary Hypertension

    Huaying He1,2, Zhiyong Lin1,2, Yuelan Weng1,2, Jianjie Zhou1,2, Man Ye1,2, Xiaowei Luo1,2, Qifeng Zhao1,2,*
    Congenital Heart Disease, Vol.16, No.6, pp. 655-673, 2021, DOI:10.32604/CHD.2021.016054
    Abstract Background: To achieve successful management of infants with congenital heart disease (CHD) together with pulmonary hypertension (PH), postoperative care, especially feeding care is vital in addition to surgery. Postoperative feeding is comprised of three stages: feeding in the intensive care unit, feeding in the general ward and family feeding, in which the general ward is considered as the “transitional stage”. At present, there is little research on the optimal mode of feeding care for the transitional stage, and there is no universally recognized and accepted protocol. Methods: We retrospectively analyzed 114 CHD infants with PH who underwent family-centered (FC) feeding… More >

  • Open Access

    CASE REPORT

    When the Blood Pressure Misleads You: A Diagnostic Conundrum in an Unusual Case of Coarctation

    Eva Kapravelou1, Hugo Issa2, Gordon Culham3, Martin Hosking1, Sanjiv K. Gandhi2, Shubhayan Sanatani1,*
    Congenital Heart Disease, Vol.16, No.6, pp. 675-680, 2021, DOI:10.32604/CHD.2021.016548
    Abstract A 4-month-old previously healthy baby was found to be in congestive heart failure with LV dysfunction and a right aortic arch with severe coarctation, undetectable by blood pressure measurements. A cardiac CT and central blood pressure led to the diagnosis of a unique anatomic variant of aortic coarctation. Once diagnosed the patient underwent surgery with an uncomplicated recovery. More >

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