Open Access
ARTICLE
Jiaxiong Wu1,2,3,#, Runzhang Liang1,#, Naijimuding ABUDUREXITI4,#, Jing Ling2, Zirui Peng2, Jinxin Li1, Canxin Wang1, Yong Zhang1, Haiyun Yuan1,2,3,*, Shusheng Wen1,2,3,*
Structural and Congenital Heart Disease, DOI:10.32604/schd.2026.077455
（This article belongs to the Special Issue: Novel Insights into Congenital Heart Disease: Pathophysiology, Biomarkers, and Future Directions)
Abstract Objective: Cone reconstruction (CR) is the preferred surgical treatment for Ebstein’s anomaly (EA). However, the molecular mechanisms underlying postoperative cardiac repair remain unclear. This study investigated the dynamic changes of plasma exosomal microRNAs (miRNAs) in EA patients before and after CR, exploring their association with postoperative cardiac function recovery and potential molecular mechanisms. Methods: Plasma samples were collected from 10 EA patients undergoing CR preoperatively, 1 day postoperatively, and 7 days postoperatively, along with samples from 10 healthy controls. Plasma exosomes were isolated using size-exclusion chromatography. Exosomal miRNAs were extracted and sequenced, followed by differential expression,… More >
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