Open Access

CASE REPORT

Yee-Tat Lee^1,2, Hay-Son Robin Chen³, Ka-Lam Calvin Leung^1,2, Chun-Ka Wong^1,2, Ho-On Alston Chiu^1,2, Chi-Wai Stephen Cheung⁴, Yuen-Hei Mak⁴, Ka-Chun Un^1,2,*
Structural and Congenital Heart Disease, DOI:10.32604/schd.2026.078486
Abstract Background: Hypoattenuating leaflet thickening (HALT) is a reported complication following percutaneous pulmonary valve implantation (PPVI) Case description: A 32-year-old man with a history of repaired Tetralogy of Fallot (TOF) underwent PPVI for symptomatic severe pulmonary regurgitation (PR). The postoperative course was complicated by HALT diagnosed by computed tomography (CT) within 24 h of the procedure. Anticoagulation therapy was administered, and reassessment CT at 4 months showed resolution of HALT. Conclusion: HALT following PPVI is managed with anticoagulation yet consensus for optimal management strategy is lacking. More >

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Open Access

ARTICLE

Meng-Zhen Zhang^1,#, Ming Li^2,#, Peng-Ju Wen¹, Yue-Heng Wu^1,*, Ling Sun^3,*
Structural and Congenital Heart Disease, DOI:10.32604/schd.2026.077380
Abstract Background: Hypertrophic cardiomyopathy (HCM) is increasingly recognized as a disease of impaired myocardial energetics, but integrated proteomic–metabolomic data from human myocardium are scarce. This study combined quantitative proteomics and untargeted metabolomics to obtain a systems-level view of myocardial remodeling and to identify pathways jointly dysregulated at the protein and metabolite levels. Methods: Myocardial tissue from 7 patients with HCM who underwent surgical myectomy and 5 healthy control donors at Guangdong Provincial People’s Hospital was analyzed by data-independent acquisition-based quantitative proteomics and Liquid Chromatography-Tandem Mass Spectrometry–based untargeted metabolomics. Differentially expressed proteins (DEPs) and metabolites were identified using… More >

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