Open Access

ARTICLE

Meryem Beyazal^*, Merter Keceli, Emine Gulsah Torun, Ibrahim Ece
Structural and Congenital Heart Disease, DOI:10.32604/schd.2026.080538
Abstract Background: Cardiac magnetic resonance (CMR) imaging following transcatheter pulmonary valve replacement (TPVR) allows for the assessment of right ventricular (RV) volume. This study aimed to evaluate early- to mid-term findings after the procedure. Methods: A total of 21 patients with repaired tetralogy of Fallot who underwent TPVR were enrolled in the study. CMR data before and after the procedure were compared. The median interval between the procedure and the post-TPVR CMR was 9 months (range: 6–18 months). Results: RV volumes and RV end-diastolic volume indices were significantly lower after TPVR compared to before the procedure. RV volume… More >

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Open Access

CASE REPORT

Ye Tan^1,2, Jing Ling^3,4,5, Zewen Chen^3,4,5, Runzhang Liang^3,4,5, Shusheng Wen^3,4,5, Yong Zhang^3,4,5,*
Structural and Congenital Heart Disease, DOI:10.32604/schd.2026.077197
Abstract Background: Congenital left ventricular diverticulum is an uncommon cardiac malformation that may present with chest pain, ventricular arrhythmia, thromboembolism, or rupture risk depending on lesion morphology and wall composition. Case description: We report an adolescent male with chest pain and frequent premature ventricular complexes who was found to have a giant apical left ventricular diverticulum with marked wall thinning and regional hypokinesia. Multimodality imaging, including transthoracic echocardiography, computed tomography, cardiac magnetic resonance, and myocardial perfusion/metabolic assessment, supported the diagnosis of a fibrous diverticulum and helped exclude ischemic myocardial injury. To refine operative planning, patient-specific dynamic three-dimensional (3D)… More >

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ARTICLE

Yanan Pan^1,2, Weize Xu^2,3,4,*, Zhiwei Zhang⁴, Mengmeng Su⁴, Xiaohua Pan⁴, Jingjing Ye^1,2,4, Jin Yu^1,2,4,*
Structural and Congenital Heart Disease, DOI:10.32604/schd.2026.079240
Abstract Background: Congenital heart disease (CHD) is characterized by a high incidence and low detection rate. The shortage of pediatric echocardiologists limits the routine ultrasound screening for CHD in many institutions. Deep learning has emerged as a promising tool to enhance the CHD diagnosis. This study aims to develop and evaluate a two-branch, two-stage intelligent algorithm (OBICnet) based on echocardiographic images to predict and classify common CHD in pediatric patients. Methods: A total of 8543 static color Doppler images from 3134 children were analyzed, with each child contributing 1 to 7 standard sectional views. The dataset was… More >

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Open Access

CASE REPORT

Yee-Tat Lee^1,2, Hay-Son Robin Chen³, Ka-Lam Calvin Leung^1,2, Chun-Ka Wong^1,2, Ho-On Alston Chiu^1,2, Chi-Wai Stephen Cheung⁴, Yuen-Hei Mak⁴, Ka-Chun Un^1,2,*
Structural and Congenital Heart Disease, DOI:10.32604/schd.2026.078486
Abstract Background: Hypoattenuating leaflet thickening (HALT) is a reported complication following percutaneous pulmonary valve implantation (PPVI) Case description: A 32-year-old man with a history of repaired Tetralogy of Fallot (TOF) underwent PPVI for symptomatic severe pulmonary regurgitation (PR). The postoperative course was complicated by HALT diagnosed by computed tomography (CT) within 24 h of the procedure. Anticoagulation therapy was administered, and reassessment CT at 4 months showed resolution of HALT. Conclusion: HALT following PPVI is managed with anticoagulation yet consensus for optimal management strategy is lacking. More >

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Open Access

ARTICLE

Meng-Zhen Zhang^1,#, Ming Li^2,#, Peng-Ju Wen¹, Yue-Heng Wu^1,*, Ling Sun^3,*
Structural and Congenital Heart Disease, DOI:10.32604/schd.2026.077380
Abstract Background: Hypertrophic cardiomyopathy (HCM) is increasingly recognized as a disease of impaired myocardial energetics, but integrated proteomic–metabolomic data from human myocardium are scarce. This study combined quantitative proteomics and untargeted metabolomics to obtain a systems-level view of myocardial remodeling and to identify pathways jointly dysregulated at the protein and metabolite levels. Methods: Myocardial tissue from 7 patients with HCM who underwent surgical myectomy and 5 healthy control donors at Guangdong Provincial People’s Hospital was analyzed by data-independent acquisition-based quantitative proteomics and Liquid Chromatography-Tandem Mass Spectrometry–based untargeted metabolomics. Differentially expressed proteins (DEPs) and metabolites were identified using… More >

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