Open Access

EDITORIAL

Xuming Mo^1,*, Kisaburo Sakamoto^2,*, Vladimiro L. Vida^3,*
Structural and Congenital Heart Disease, Vol.21, No.1, 2026, DOI:10.32604/schd.2026.080525 - 31 March 2026
Abstract This article has no abstract. More >

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ARTICLE

Xuming Mo^1,*, Taibing Fan^2,*, Zhongdong Hua^3,*, Christoph Haller⁴, Shinichiro Oda⁵, Shuhua Luo⁶, Weijie Liang², Yuzhong Yang¹, Huaipu Liu³, Nianguo Dong⁷, Shoujun Li⁸, Xinxin Chen⁹, Jimei Chen¹⁰, Hao Zhang¹¹, Qiang Shu¹², Haibo Zhang¹¹, Quansheng Xing¹³, Jinghao Zheng¹¹, Xiaofeng Li¹⁴, Teng Ming¹⁵, Qi An¹⁶, Ping Wen¹⁷, Qiang Wang¹⁸, Jirong Qi¹, Huiwen Chen¹¹, Shusheng Wen¹⁹, Rui Chen²⁰, Ming Ye²¹, Keming Yang⁸, Minhua Fang²², Caixia Liu²³, Ke Lin¹⁶, Zhongshi Wu²⁴, Xiangming Fan¹², Zhengxia Pan²⁵, Yiqun Ding²⁶, Ming’an Pi²⁷, Xin Li²⁸, Yong Zou²⁹, Shuguang Tao³⁰, Renwei Chen³¹, Li Ma⁹, Libing Zhang³², Tao You³³, Dongshan Liao³⁴, Cheng Zhou³⁵, Hongxin Li³⁶, Gengxu Zhou³⁷, Chunhu Gu³⁸, Zhiqiang Li³⁹, Yonggang Li²⁵, Hui Zhang⁴⁰, Xiaomin He¹¹, Yanan Lu¹¹, Haifa Hong⁴¹, Benqing Zhang⁸, Li Gong²⁷, Jiafeng Qi⁴², Song Bai³⁹, Yuhang Liu⁴³, Tianli Zhao²⁴, Cardiothoracic Surgery Group, Pediatric Surgery Branch of Chinese Medical Doctor Association, Cardiac Surgery Group, Pediatric Surgery Branch of Chinese Medical Association, the Asian Association for Pediatric and Congenital Heart Surgery
Structural and Congenital Heart Disease, Vol.21, No.1, 2026, DOI:10.32604/schd.2026.077974 - 31 March 2026
Abstract Congenital heart disease (CHD) is a common birth defect in children, and surgical intervention is the primary treatment. The traditional standard median sternotomy (MS) has drawbacks such as significant trauma and obvious scarring. The right axillary incision (RAI) has gradually become a conventional approach due to its advantages of preserving thoracic cage integrity, small incision size, rapid recovery, and hidden scarring. However, there is currently a lack of relevant guidelines and consensus for its application. This consensus adopts the international Delphi process, systematically searching domestic and foreign literature on CHD from 1982 to 2024. It… More >

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ARTICLE

Jia Yuan^1,2,#, Yanxing Lv^2,#, Xinyuan Ding³, Yunyi Zeng¹, Li Ma⁴, Hang Yang¹, Lin Jiang¹, Kamil Bildebayev⁵, Boiko Yuliya Nikolaevna⁵, Na Zhou^1,*
Structural and Congenital Heart Disease, Vol.21, No.1, 2026, DOI:10.32604/schd.2026.076648 - 31 March 2026
Abstract Backgorund: Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare congenital anomaly of coronary artery anatomy, usually diagnosed in infancy, but adults may also be affected by this deformity. Objectives: The aim of this study is to examine long-term outcomes in patients with ALCAPA and analyze the relevant factors influencing postoperative outcomes. Methods: The records of patients with ALCAPA admitted from January 2015 to December 2024 were retrospectively reviewed. Clinical data of the patients were retrieved from the records. The follow-up data included mortality rates and complications. Kaplan-Meier survival curves were… More >

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ARTICLE

Xiaofeng Wang^1,#, Da Huo^2,3,#, Shuo Li^4,#, Wenlong Wang¹, Qian Zhang¹, Ya Gao⁵, Xu Wang^1,*
Structural and Congenital Heart Disease, Vol.21, No.1, 2026, DOI:10.32604/schd.2026.077612 - 31 March 2026
Abstract Background: This study evaluated the impact of a comprehensive prevention program, which integrated eight evidence-based measures consistent with current clinical guidelines and practice standards, on ventilator-associated pneumonia (VAP) rates in a pediatric cardiac surgical intensive care unit (ICU). Methods: A quasi-experimental study was conducted from 2023 to 2024. We compared VAP rates across a 5-month pre-intervention period, a 12-month intervention period, and a 7-month post-intervention period in patients receiving mechanical ventilation for over 48 h. Additional outcomes, including postoperative length of stay were also assessed before and after the intervention. Results: Among 829 at-risk patients and 5677… More >

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CASE REPORT

Mete Han Kizilkaya¹, Boran Cakan^2,3,*, Mehmet Bicer⁴, Ender Odemis^1,5
Structural and Congenital Heart Disease, Vol.21, No.1, 2026, DOI:10.32604/schd.2026.074189 - 31 March 2026
Abstract Background: Transcatheter closure of perimembranous ventricular septal defects (pmVSDs) with Lifetech™ Konar-Multifunctional Occluder (MFO) has demonstrated high procedural success and safety. However, long-term complications due to valve–device interaction are rarely reported. We describe a pediatric patient who developed progressive right ventricular outflow tract (RVOT) obstruction and severe tricuspid regurgitation 20 months after MFO closure, highlighting mechanisms, management, and outcomes. Case Description: A 13-year-old girl underwent successful MFO closure of a 6-mm pmVSD. Early follow-up showed trivial tricuspid regurgitation and mild subpulmonic stenosis. Pre-procedural imaging revealed right ventricular hypertrophy caused by long-standing jet-related turbulence from the pmVSD, with… More >

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CASE REPORT

Ricardo Garcia-Mora¹, Gunther Hernández-Morales², Miguel Ángel Chagolla-Santillán³, Iliana Acevedo-Bañuelos³, Jorge Luis Cervantes-Salazar⁴, Edel Rafael Rodea-Montero^5,*
Structural and Congenital Heart Disease, Vol.21, No.1, 2026, DOI:10.32604/schd.2026.071470 - 31 March 2026
Abstract We report a full-term newborn with pulmonary atresia with an intact ventricular septum who developed acute hypoxemia after ductal stent embolization. Emergency surgery was performed to remove the stent and create a central systemic-to-pulmonary shunt using a 3.5 mm GORE-TEX^® graft via a modified Gates, Laks, and Johnson technique. Postoperative recovery was favorable. At 24 months, the shunt remained patent with adequate pulmonary artery growth. This case underscores prompt surgical rescue and supports central shunting as an effective mid-term solution. More >

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REVIEW

Jiafei He^1,2, Ailixiati Alifu², Haifan Wang², Renwei Chen^1,2,*
Structural and Congenital Heart Disease, Vol.21, No.1, 2026, DOI:10.32604/schd.2026.075858 - 31 March 2026
Abstract Hyperglycemia in pregnancy (HIP) is an important independent risk factor for congenital heart disease (CHD) in offspring. With an increasing number of women of childbearing age experiencing gestational hyperglycemia, the impact of an intrauterine hyperglycemic environment on fetal development has drawn significant attention. However, the teratogenic mechanisms underlying its effects on cardiac development remain incompletely understood. This review systematically analyzes relevant literature to summarize its underlying mechanisms and key findings: A hyperglycemic environment disrupts cardiac neural crest cell migration, differentiation, and the proliferation/apoptosis balance of cardiomyocytes by inducing oxidative stress, endoplasmic reticulum stress, and inflammatory… More >

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ARTICLE

Yiheng Pang^1,#, Naixia Chao^2,#, Hongji Li³, Mingxi Xie³, Chunxia Wang^4,*, Ge Xu^1,*
Structural and Congenital Heart Disease, Vol.21, No.1, 2026, DOI:10.32604/schd.2026.072858 - 31 March 2026
Abstract Background: Hypoplastic left heart syndrome (HLHS) is a congenital heart disease (CHD), and accumulating evidence has implicated ferroptosis in the pathogenesis of HLHS. Therefore, exploring ferroptosis-related genes (FRGs) in HLHS is of clinical significance. Materials and Methods: Gene Expression Omnibus (GEO) was accessed to obtain analytical data. WGCNA was employed to screen relevant module genes, and the limma package was used to identify differentially expressed genes (DEGs). The rfe function in the R package caret and the glmnet package were utilized to conduct SVM-RFE and LASSO regression analyses, and the intersection of these two analyses was taken… More >

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