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Norman Aiad^1,2,3,7, Mark V. Sherrid^1,7, Adam J. Small¹, Youssef Elnabawi^1,7, Jodi Feinberg¹, Leon Axel^1,4, Ralph Mosca⁵, T. K. Susheel Kumar⁵, Michael Argilla⁶, Dan G. Halpern^1,7,*
Congenital Heart Disease, Vol.18, No.3, pp. 267-277, 2023, DOI:10.32604/chd.2023.025853
Abstract Introduction: We sought to investigate whether the development of sub-pulmonic systolic anterior motion (SAM) may be inherent to the anatomy of the the mitral valve (MV) or affected by external factors, such as a dilated right ventricle or chest abnormalities in d-looped transposition of the great arteries post atrial switch operation (d-TGA/AtS). Methods: Analysis was performed of clinical and cardiac imaging studies acquired on 19 adult patients with d-TGA/AtS (age 42 ± 6 years old, 56% male) between 2015–2019. Echocardiography data included mitral apparatus anatomy, and CT/MRI data included biventricular dimensions, function, and Haller index (HI) for pectus deformity. Results:… More >

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Ingo Paetsch^1,*, Roman Gebauer², Christian Paech², Frank-Thomas Riede², Sabrina Oebel¹, Andreas Bollmann¹, Christian Stehning³, Jouke Smink⁴, Ingo Daehnert², Cosima Jahnke¹
Congenital Heart Disease, Vol.18, No.3, pp. 279-294, 2023, DOI:10.32604/chd.2023.029634
Abstract Background: In congenital heart disease (CHD) patients, detailed three-dimensional anatomy depiction plays a pivotal role for diagnosis and therapeutical decision making. Hence, the present study investigated the applicability of an advanced cardiovascular magnetic resonance (CMR) whole heart imaging approach utilizing nonselective excitation and compressed sensing for anatomical assessment and interventional guidance of CHD patients in comparison to conventional dynamic CMR angiography. Methods: 86 consecutive pediatric patients and adults with congenital heart disease (age, 1 to 74 years; mean, 35 years) underwent CMR imaging including a free-breathing, ECG-triggered 3D nonselective SSFP whole heart acquisition using compressed SENSE (nsWHcs). Anatomical assessability and… More >

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Henry P. Foote¹, Huali Wu², Stephen J. Balevic^1,2, Elizabeth J. Thompson^1,2, Kevin D. Hill^1,2, Eric M. Graham³, Christoph P. Hornik^1,2, Karan R. Kumar^1,2,*
Congenital Heart Disease, Vol.18, No.3, pp. 295-313, 2023, DOI:10.32604/chd.2023.026262
Abstract Background: Infants undergoing cardiac surgery with cardiopulmonary bypass (CPB) frequently receive intra-operative methylprednisolone (MP) to suppress CPB-related inflammation; however, the optimal dosing strategy and efficacy of MP remain unclear. Methods: We retrospectively analyzed all infants under 90 days-old who received intra-operative MP for cardiac surgery with CPB from 2014–2017 at our institution. We combined real-world dosing data from the electronic health record (EHR) and two previously developed population pharmacokinetic/pharmacodynamic models to simulate peak concentration (Cmax) and area under the concentration-time curve for 24 h (AUC24) for MP and the inflammatory cytokines interleukin-6 (IL-6) and interleukin-10 (IL-10). We evaluated the relationships… More >

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Daniel Sweeney¹, Scott Cohen^2,3, Salil Ginde^2,3, Jennifer Gerardin^2,3, Peter Bartz^2,3, Matthew Buelow^2,3,*
Congenital Heart Disease, Vol.18, No.3, pp. 315-323, 2023, DOI:10.32604/chd.2023.027349
Abstract Background: Women with congenital heart disease (CHD) have increased risk for adverse events during pregnancy and delivery. Prior studies have assessed pregnancy and delivery outcomes at tertiary referral centers (TRC). The aim of our study was to assess pregnancy outcomes in women with CHD who deliver in a non-tertiary referral center (non-TRC). Methods: Clinical demographics were collected, including anatomic complexity, physiologic state and pre-pregnancy risk assessment. Patients were stratified by delivery location, either TRC or non-TRC. Maternal and neonatal complications of pregnancy were reported. Results: Women with CHD who delivered in a TRC had a higher pre-pregnancy risk when assessed… More >

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Jae Gun Kwak¹, Eung Re Kim², Taeyoung Yun¹, Sungkyu Cho¹, Chang-Ha Lee², Woong-Han Kim^1,*
Congenital Heart Disease, Vol.18, No.3, pp. 325-336, 2023, DOI:10.32604/chd.2023.027758
Abstract Objectives: To access the effectiveness of our modified right-ventricular overhauling procedure on tricuspid valve (TV) growth in patients with pulmonary atresia with intact ventricular septum (PAIVS). Methods: We retrospectively reviewed 21 patients with PAIVS who underwent modified right ventricular overhauling (mRVoh) between 2008 and 2019 at two institutions. Our mRVoh consisted of wide resection of hypertrophied infundibular and trabecular muscle, peeling off fibrotic endocardial tissue in the right ventricle (RV) cavity, surgical pulmonary valvotomy, and Blalock-Taussig shunt or banding of ductus arteriosus under cardiopulmonary bypass. The TV annulus sizes were measured and analyzed using echocardiography before and after mRVoh. Results:… More >

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Siegfried Geyer^1,*, Claudia Dellas², Thomas Paul², Matthias Müller², Kambiz Norozi^2,3,4
Congenital Heart Disease, Vol.18, No.3, pp. 337-348, 2023, DOI:10.32604/chd.2023.028827
Abstract Objectives: To examine whether patients with congenital heart disease (CHD) are less likely to have a partner or children than individuals from the general population. Methods: Longitudinal study with two assessments of the same patients (n = 244) from a hospital population and controls (n = 238) from the German Socio-Economic Panel (GSOEP) using parental education, patients age, and sex as matching criteria. The first patient study was conducted between 5/2003 and 6/2004, the second one between 5/2017 and 4/2019. Controls were drawn from GSOEP-surveys 2004 and 2018. CHD-severity was classified according to type of surgery: curative, reparative, or palliative.… More >

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Birgitta Svensson^1,2,*, Petru Liuba^1,2, Anne Wennick³, Malin Berghammer^4,5
Congenital Heart Disease, Vol.18, No.3, pp. 349-359, 2023, DOI:10.32604/chd.2023.028391
Abstract Background: Parents of children with complex right ventricular outflow tract (RVOT) anomalies are confronted with their child’s need for heart surgery early in life and repeated reoperations later on. Preoperative assessment needs to be performed whenever an indication for reoperation is suspected. The aim was to illuminate the experiences of parents of children diagnosed with RVOT anomalies, in particular, how they experience their child’s heart disease and everyday life during the assessment and after the decision on whether to perform a reoperation. Method: Individual interviews (n = 27) were conducted with nine parents on three occasions between 2014 and 2016 and analyzed… More >

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Ivana B. Cerović¹, Vladislav A. Vukomanović^1,2, Jovan Lj. Košutić^1,2, Mila S. Stajević^1,2, Sanja S. Ninić¹, Saša S. Popović¹, Ivan D. Dizdarević¹, Staša D. Krasić¹, Sergej M. Prijić^1,2,*
Congenital Heart Disease, Vol.18, No.3, pp. 361-371, 2023, DOI:10.32604/chd.2023.026533
Abstract Introduction: Transcatheter closure is an alternative to ventricular septal defect (VSD) occlusion surgery. Nit-Occlud Lê VSD coil is a new device yet to be evaluated. The study aimed to evaluate immediate and midterm results after transcatheter closure with the Nit-Occlud Lê VSD device. Methods: The retrospective analysis included 30 patients with VSD referred for closure during the period from October 2015 to December 2020. Results: At the time of intervention, the patients’ mean age and body weights were 7.5 ± 5.6 years and 29.3 ± 19.1 kg. The majority of the defects had perimembranous location (24/30), four defects had muscular and two outlet subaortic position.… More >

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Xingbang Li^1,#, Xuan Zheng^2,#, Bowen Jin¹, Yunyan Li¹, Yongyu Shao¹, Xiaoxian Deng¹, Dingyang Li¹, Shanshan Li¹, Hongmei Zhou¹, Jie Zhang³, Xianya Zhang⁴, Qunshan Shen¹, Gangcheng Zhang^2,*
Congenital Heart Disease, Vol.18, No.3, pp. 373-385, 2023, DOI:10.32604/chd.2023.028979
Abstract Background: Transcatheter closure of patent foramen ovale (PFO) has been widely accepted as a highly effective way to treat high-risk PFO-related diseases. However, traditional non-degradable occluders made of metal alloys will permanently exist in the body, resulting in thrombosis, valve damage, hemolysis, arrhythmia, or other complications. The biodegradable PFO occluder developed by Shanghai Mallow Medical Instrument Co., Ltd., China can be fully absorbed and degrade into nontoxic ingredients, reducing postoperative complications. Objectives: To study the safety and efficacy of biodegradable PFO occluders in treating PFO. Methods: This single-center clinical trial collected 30 patients treated with a biodegradable PFO occluder. The… More >

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Xiaoxue Zhou¹, Tingyang Yang², Ye Zhang¹, Yanping Ruan¹, Jiancheng Han¹, Xiaowei Liu¹, Ying Zhao¹, Xiaoyan Gu¹, Tingting Liu¹, Hairui Wang¹, Yihua He^1,*
Congenital Heart Disease, Vol.18, No.3, pp. 387-397, 2023, DOI:10.32604/chd.2023.029060
Abstract Background: Atrioventricular septal defects (AVSDs) are screened and diagnosed usually rely on the imaging characteristics of fetal echocardiography (FE). However, diagnosis on images is heavily depended on sonographers’ experience and the quantitative data are rarely studied. Objective: This study aimed to realize the prenatal diagnosis of AVSDs by analyzing the quantitative data on FE. Methods: One hundred and thirteen cardiac quantitative data was analyzed in 370 normal and 49 AVSDs fetuses retrospectively. The top six with the highest diagnostic accuracy rate were acquired according to the area under the curve (AUC), and the diagnostic value of six variables was analyzed.… More >

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