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    ARTICLE

    From Limited Samples to Mechanistic Insights: Exploring Ferroptosis-Related Genes in Hypoplastic Left Heart Syndrome

    Yiheng Pang1,#, Naixia Chao2,#, Hongji Li3, Mingxi Xie3, Chunxia Wang4,*, Ge Xu1,*
    Structural and Congenital Heart Disease, DOI:10.32604/schd.2026.072858
    Abstract Background: Hypoplastic left heart syndrome (HLHS) is a congenital heart disease (CHD), and accumulating evidence has implicated ferroptosis in the pathogenesis of HLHS. Therefore, exploring ferroptosis-related genes (FRGs) in HLHS is of clinical significance. Materials and Methods: Gene Expression Omnibus (GEO) was accessed to obtain analytical data. WGCNA was employed to screen relevant module genes, and the limma package was used to identify differentially expressed genes (DEGs). The rfe function in the R package caret and the glmnet package were utilized to conduct SVM-RFE and LASSO regression analyses, and the intersection of these two analyses was taken… More >

  • Open Access

    EDITORIAL

    Editorial: Announcing the Renaming of Our Journal

    Xuming Mo1,*, Kisaburo Sakamoto2,*, Vladimiro L. Vida3,*
    Structural and Congenital Heart Disease, DOI:10.32604/schd.2026.080525
    Abstract This article has no abstract. More >

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