Open Access

ARTICLE

Xiaofeng Wang^1,#, Da Huo^2,3,#, Shuo Li^4,#, Wenlong Wang¹, Qian Zhang¹, Ya Gao⁵, Xu Wang^1,*
Structural and Congenital Heart Disease, DOI:10.32604/schd.2026.077612
Abstract Background: This study evaluated the impact of a comprehensive prevention program, which integrated eight evidence-based measures consistent with current clinical guidelines and practice standards, on ventilator-associated pneumonia (VAP) rates in a pediatric cardiac surgical intensive care unit (ICU). Methods: A quasi-experimental study was conducted from 2023 to 2024. We compared VAP rates across a 5-month pre-intervention period, a 12-month intervention period, and a 7-month post-intervention period in patients receiving mechanical ventilation for over 48 h. Additional outcomes, including postoperative length of stay were also assessed before and after the intervention. Results: Among 829 at-risk patients and 5677… More >

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ARTICLE

Jia Yuan^1,2,#, Yanxing Lv^2,#, Xinyuan Ding³, Yunyi Zeng¹, Li Ma⁴, Hang Yang¹, Lin Jiang¹, Kamil Bildebayev⁵, Boiko Yuliya Nikolaevna⁵, Na Zhou^1,*
Structural and Congenital Heart Disease, DOI:10.32604/schd.2026.076648
Abstract Backgorund: Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare congenital anomaly of coronary artery anatomy, usually diagnosed in infancy, but adults may also be affected by this deformity. : Objectives: The aim of this study is to examine long-term outcomes in patients with ALCAPA and analyze the relevant factors influencing postoperative outcomes. Methods: The records of patients with ALCAPA admitted from January 2015 to December 2024 were retrospectively reviewed. Clinical data of the patients were retrieved from the records. The follow-up data included mortality rates and complications. Kaplan-Meier survival curves… More >

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REVIEW

Jiafei He^1,2, Ailixiati Alifu², Haifan Wang², Renwei Chen^1,2,*
Structural and Congenital Heart Disease, DOI:10.32604/schd.2026.075858
Abstract Hyperglycemia in pregnancy (HIP) is an important independent risk factor for congenital heart disease (CHD) in offspring. With an increasing number of women of childbearing age experiencing gestational hyperglycemia, the impact of an intrauterine hyperglycemic environment on fetal development has drawn significant attention. However, the teratogenic mechanisms underlying its effects on cardiac development remain incompletely understood. This review systematically analyzes relevant literature to summarize its underlying mechanisms and key findings: A hyperglycemic environment disrupts cardiac neural crest cell migration, differentiation, and the proliferation/apoptosis balance of cardiomyocytes by inducing oxidative stress, endoplasmic reticulum stress, and inflammatory… More >

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ARTICLE

Yiheng Pang^1,#, Naixia Chao^2,#, Hongji Li³, Mingxi Xie³, Chunxia Wang^4,*, Ge Xu^1,*
Structural and Congenital Heart Disease, DOI:10.32604/schd.2026.072858
Abstract Background: Hypoplastic left heart syndrome (HLHS) is a congenital heart disease (CHD), and accumulating evidence has implicated ferroptosis in the pathogenesis of HLHS. Therefore, exploring ferroptosis-related genes (FRGs) in HLHS is of clinical significance. Materials and Methods: Gene Expression Omnibus (GEO) was accessed to obtain analytical data. WGCNA was employed to screen relevant module genes, and the limma package was used to identify differentially expressed genes (DEGs). The rfe function in the R package caret and the glmnet package were utilized to conduct SVM-RFE and LASSO regression analyses, and the intersection of these two analyses was taken… More >

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EDITORIAL

Xuming Mo^1,*, Kisaburo Sakamoto^2,*, Vladimiro L. Vida^3,*
Structural and Congenital Heart Disease, DOI:10.32604/schd.2026.080525
Abstract This article has no abstract. More >

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