Home / Journals / CHD / Vol.16, No.4, 2021
  • Open Access

    REVIEW

    Fetal Bradyarrhythmias: Etiopathogenesis, Diagnosis and Treatment: Between Literature Review and Experience of a Tertiary Center

    Elio Caruso*, Silvia Farruggio, Salvatore Agati, Corrado Di Mambro
    Congenital Heart Disease, Vol.16, No.4, pp. 309-331, 2021, DOI:10.32604/CHD.2021.015470
    Abstract Fetal arrhythmias reach up around 10% of the total third-level perinatal cardiology references. Sustained bradycardia is defined as a baseline fetal heart rate (FHR) of less than 110 bpm sustained for at least 10 min. The overall incidence of malignant fetal bradyarrhythmias, such as complete atrioventricular block (AVB) and channellopathies, is relatively rare, 1:5000 pregnancies, but represents a serious emergency for the gynecologist, neonatologists, and pediatric cardiologists. Fetal complete AVB is strongly associated with maternal connective tissue disease, but it can be also associated with congenital heart disease and usually with a poorer prognosis with high risk of fetal hydrops… More >

  • Open Access

    ARTICLE

    Hypertension and Heart Failure as Predictors of Mortality in an Adult Congenital Heart Defect Population

    Cheryl Raskind-Hood1,*, Kashaine A. Gray2,3, Jayne Morgan3, Wendy M. Book4,*
    Congenital Heart Disease, Vol.16, No.4, pp. 333-355, 2021, DOI:10.32604/CHD.2021.014384
    Abstract Early intervention to prevent premature mortality is vital for adults with congenital heart defects (CHD). Anatomic complexity and comorbid conditions are thought to contribute to CHD mortality. Since hypertension (HTN) and heart failure (HF) are the comorbid conditions among the most prevalent causes of death in the United States, and commonly accompany CHD, it is crucial to evaluate whether they are reliable predictors of mortality for adults with CHD (ACHD) independent of anatomic CHD complexity. A retrospective cross-sectional analysis of ACHD, aged 18–64, with concomitant HTN and/or HF and at least one health care encounter during 2008–2010 were assessed. Of… More >

  • Open Access

    ARTICLE

    Systolic and Diastolic Strain Measurements Show Left Ventricular Dysfunction in Women with Turner Syndrome

    Allard T. van den Hoven1, Sultan Yilmazer1, Lidia R. Bons1, Roderick W. J. van Grootel1, L. W. Geenen1, An M. van Berendoncks1, Anthonie L. Duijnhouwer2, Hans-Marc J. Siebelink3, Jolien W. Roos-Hesselink1, Annemien E. van den Bosch1,*
    Congenital Heart Disease, Vol.16, No.4, pp. 357-368, 2021, DOI:10.32604/CHD.2021.014462
    Abstract Aim: This study aimed to describe the systolic left ventricular global longitudinal strain (LvGLS) and left ventricular peak early diastolic strain rate (Sre) in adult women with Turner syndrome (TS) and to determine its relationship with exercise capacity and clinical parameters. Methods: In this cross-sectional cohort study, consecutively included adult TS women underwent an electrocardiogram, transthoracic echocardiogram (TTE) and cardiopulmonary exercise test (CPET) on the same day. LvGLS and Sre were measured using 2D speckle tracking analysis (STE) and compared with age-matched healthy female controls. Results: Ninety-four adult women (age 36 ± 13 years) with TS and 32 healthy age-matched… More >

  • Open Access

    CASE REPORT

    Isolation of the Left Subclavian Artery in D-Transposition of the Great Arteries with Right Aortic Arch

    Kotaro Hine*, Kohei Ogata, Keiko Saitou, Norio Mizukaki, Hiroko Arai, Hitoshi Yoda
    Congenital Heart Disease, Vol.16, No.4, pp. 369-371, 2021, DOI:10.32604/CHD.2021.014516
    Abstract Abnormal branching of the aorta associated with the right aortic arch (RAA) has been reported as isolation of left subclavian artery (ILSA), isolation of left common carotid artery, isolation of brachiocephalic artery. ILSA is a rare aortic branch anomaly that originates in the left subclavian artery from the pulmonary artery via ductus arteriosus. Several reports have described ILSA associated with 22q11.2 deletion syndrome and tetralogy of Fallot. Here, we present a very unusual case of RAA with ILSA associated with D-transposition of the great arteries and inferior vena cava interrupted with azygos continuation. More >

  • Open Access

    ARTICLE

    Plasma HGF and OPN as Potential Biomarkers of Pulmonary Arterial Hypertension in Congenital Heart Disease

    Dongdong Zheng1,#, Chi Shen1,2,#, Wenshi Liu1, Wenjing Lv1, Xiaofei Li1,*
    Congenital Heart Disease, Vol.16, No.4, pp. 373-381, 2021, DOI:10.32604/CHD.2021.015260
    Abstract Objectives: Pulmonary arterial hypertension in congenital heart disease (PAH-CHD) is the most common type of PAH and increases morbidity and mortality in patients with CHD. Right heart catheterization (RHC) is the standard method to diagnose PAH. However, RHC is an invasive and complicated method with relatively high cost. Noninvasive, feasible, and cost-efficient methods are urgently needed. The objective of this study was to evaluate three potential biomarkers of PAH-CHD: Hepatocyte growth factor (HGF), osteopontin (OPN), and suppression of tumorigenicity 2 (ST2). Methods: Plasma samples were collected from patients with CHD (n = 46) and healthy individuals (n = 22) and… More >

  • Open Access

    ARTICLE

    Natural History of Kawashima Palliation in Single-Ventricle and Interrupted Inferior Vena Cava Heart Disease in China 11 Years Result

    Yajuan Zhang, Jun Yan*, Qiang Wang, Shoujun Li, Jing Sun, Shuo Dong, Jiachen Li
    Congenital Heart Disease, Vol.16, No.4, pp. 383-392, 2021, DOI:10.32604/CHD.2021.015479
    Abstract Background: The long-term outcomes of patients treated with a Kawashima procedure and keeping the antegrade pulmonary blood flow (AnPBF) in single-ventricle (SV) and interrupted inferior vena cava (IVC) heart disease is still uncertain as yet. Methods: We investigated 18 patients who underwent the Kawashima procedure with SV physiology and an interrupted IVC between January 2009 and June 2018, perioperative, operative and postoperative characteristics were recorded. Results: A total of 18 patients underwent the Kawashima procedure at a median age of 2.7 years (range 0.5–24.7 years), of which 12 (66.7%) were male and 6 (33.3%) were female. The mean saturation was… More >

  • Open Access

    CASE REPORT

    An Unusual Cause of Irritability in a Single Ventricle Patient after Bidirectional Glenn Shunt

    Sarah Pradhan1,*, Eileen Broomall2, Russel Hirsch1
    Congenital Heart Disease, Vol.16, No.4, pp. 393-396, 2021, DOI:10.32604/CHD.2021.015257
    Abstract The differential diagnosis for irritability in children is broad. In patients with congenital heart disease, one must strongly consider cardiac etiologies such as low cardiac output or elevated central venous pressure (CVP). In patients with single-ventricle physiology, the second stage of palliation includes bidirectional Glenn, which involves anastomosis of the superior vena cava to the pulmonary artery resulting in volume offloading of the single systemic ventricle. Typically, early in the post-operative period, patients may experience a headache due to the acute increase in CVP, and symptoms improve over time. Idiopathic intracranial hypertension (IIH), also known as pseudotumor cerebri, is a… More >

  • Open Access

    ARTICLE

    High Prevalence of Genetic Alterations in Infantile-Onset Cardiomyopathy

    Junsung Park1, Go Hun Seo2, Yena Lee1, Yunha Choi1, Minji Kang3, Hyo-Sang Do3, Young-Hwue Kim4, Jeong Jin Yu4, Ellen Ai-Rhan Kim5, Euiseok Jung5, Byong Sop Lee5, Jae Suk Baek4,#,*, Beom Hee Lee1,6,#,*
    Congenital Heart Disease, Vol.16, No.4, pp. 397-410, 2021, DOI:10.32604/CHD.2021.015167
    Abstract Background and Method: The genetic cause of infantile-onset cardiomyopathy is rarely investigated. Here, we conducted whole exome sequencing (WES) and mitochondrial DNA (mtDNA) sequencing in eight patients with infantile-onset cardiomyopathy to identify genetic variations. Result: Among these patients, two (25%) had dilated cardiomyopathy (DCMP), two (25%) had left ventricular non-compaction (LVNC), and four (50%) had hypertrophic cardiomyopathy (HCMP). Except four patients identified prenatally, the remaining patients presented at a median age of 85.5 days. WES identified genetic variants in a total of seven (87.5%) patients and mtDNA sequencing in the other case. TPM1 and MYH7 variants were identified in the… More >

  • Open Access

    CASE REPORT

    Scimitar Syndrome: Role of Right Atrial Longitudinal Strain. A Case Report

    Isabella Leo1, Jolanda Sabatino1,2,3, Sabrina La Bella1, Antonio Strangio1, Iolanda Aquila1, Concetta Procopio1, Carmen Anna Maria Spaccarotella1, Maria Petullà4, Salvatore De Rosa1,2, Ciro Indolfi1,2,5,*
    Congenital Heart Disease, Vol.16, No.4, pp. 411-416, 2021, DOI:10.32604/CHD.2021.015062
    Abstract We describe a case of a rare congenital heart disorder, scimitar syndrome, diagnosed in an adult woman presenting with dyspnea on exertion, chest pain and recurrent episodes of pulmonary infections. The hallmark of the syndrome is the presence of an enlarged anomalous pulmonary vein draining into the inferior vena cava. Speckle tracking echocardiography, including the often-forgotten atrial strain evaluation, is a sensitive parameter that should be routinely used for a better clinical and prognostic evaluation of patients with congenital heart disease (CHD). More >

  • Open Access

    CASE REPORT

    Arrhythmias in Common Arterial Trunk (CAT): Uncommon Atrial Tachycardia in CAT with Anomalous Pulmonary Venous Connection and Re-entry Atrial Tachycardia in CAT with HIV Seropositive Mother

    Elio Caruso1, Silvia Farruggio1,*, Davide Calvaruso1, Corrado Di Mambro1, David Angel Ortiz Ruiz1, Salvatore Agati1, Rafie Khoargami2
    Congenital Heart Disease, Vol.16, No.4, pp. 417-425, 2021, DOI:10.32604/CHD.2021.015808
    Abstract We show a brief report of two common arterial trunk cases (CAT) with different arrhythmias and discuss anatomy, clinical and diagnostic management. The burden of volume and pressure overload of this cardiac malformation may predispose to different types of arrhythmia before and after surgical repair. Because of labile hemodynamic state in this group of patients, prompt diagnosis of any arrhythmia is mandatory as the devastating factor on prognosis. The first patient with a diagnosis of CAT Type II Collett and Edwards (CE) had a particular history with HIV seropositive mother assuming antiretroviral therapy during pregnancy, who presented hyperbilirubinemia and liver… More >

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