Open Access
ARTICLE
Sheetal R. Patel1,2,*, David M. Kwiatkowski3, Adin-Cristian Andrei2, Ankita Devareddy2, Hangzhi Shi2, Catherine D. Krawczeski4, Natalie Ebert5, Barbara J. Deal1,2, Craig B. Langman2,6, Bradley S. Marino1,2
Congenital Heart Disease, Vol.15, No.4, pp. 181-195, 2020, DOI:10.32604/CHD.2020.012097
Abstract Objectives: The Fontan operation has increased survival in patients with
single-ventricle congenital heart defects. However, Fontan survivors are at risk of other
organ dysfunctions, such as renal dysfunction (RD). The objectives of this study are to
assess the prevalence of and potential risk factors for RD among Fontan survivors.
Design, setting, and patients: We performed a two-center, cross-sectional study that
included Fontan survivors evaluated in outpatient-clinics for routine follow up between
01/08-12/16. Outcome measures: The primary outcome was the presence of RD
defined by estimated glomerular filtration rate (eGFR) of <90 ml/min/1.73 m2 derived
using the serum creatinine-based Full Age… More >
Open Access
CASE REPORT
Naveed Rabbani1,*, Sarah Hofman DeYoung2, Ronald L. Gibson2, Jeffrey Conwell1, Jason F. Deen1
Congenital Heart Disease, Vol.15, No.4, pp. 197-201, 2020, DOI:10.32604/CHD.2020.011527
Abstract Persistent left superior vena cava (PLSVC) is a relatively common
congenital venous anomaly that typically drains into the coronary sinus without
hemodynamic significance. Rarely a PLSVC drains directly into the left atrium,
forming a right-to-left shunt that can result in hypoxemia and potential paradoxical
embolism. We present the case of a 2-year-old medically complex child on chronic
mechanical ventilation with eventual diagnosis of episodic hypoxemia due to a
PLSVC draining into the left atrium with position-dependent venous flow. The lesion
was identified with contrast echocardiography and cardiac MRI. Subsequent occlusion with a vascular plug resulted in resolution of the child’s… More >
Open Access
ARTICLE
Mohd Nizam Mat Bah*, Mohd Hanafi Sapian, Hasliza Razak, Emieliyuza Yusnita Alias
Congenital Heart Disease, Vol.15, No.4, pp. 203-216, 2020, DOI:10.32604/CHD.2020.013057
Abstract Introduction: Fetal echocardiogram allows early detection of critical
congenital heart disease leading to a better outcome. However, data from lowerand middle-income countries is scarce. This study aims to evaluate the diagnostic
error of fetal echocardiography and its impact on planned neonatal management.
Methods and material: This retrospective observational cohort study includes all
high-risk pregnant mothers who had fetal echocardiograms from 2008 to 2017.
Fetal and postnatal echocardiograms were compared, while the diagnostic errors
were categorized into false positive, false negative, and discrepant diagnoses. The
impact of the diagnostic error on planned neonatal management and the long-term
outcome was determined by… More >
Open Access
ARTICLE
Angeles Fuertes-Moure1, Michael Meyer2,3, Anna-Luisa Häcker2,3, Barbara Reiner2,3, Leon Brudy3, Sonia Pértega-Diaz4, Renate Oberhoffer2,3, Peter Ewert2, Jan Müller2,3,*
Congenital Heart Disease, Vol.15, No.4, pp. 217-227, 2020, DOI:10.32604/CHD.2020.011771
Abstract Objective: Health-related quality of life (HRQoL) has become an
important outcome measure for patients with congenital heart disease (CHD).
The aim of this study was to evaluate the natural course of HRQoL from longitudinal assessment in children with CHD. Patients and Methods: From July
2014 to February 2020 this longitudinal study recruited 317 children with CHD
(113 girls, 35.6%) aged 6 to 18 years (11.6 ± 2.9 years). HRQoL was assessed
with the generic, self-reported and age-adapted KINDL® questionnaire. During
a mean follow-up period of 2.2 ± 1.3 years, 195 patients had one HRQoL reassessment, 70 two, 40 three and… More >
Open Access
ARTICLE
Carter Biewen1,*, Hitendra Patel2, Olaf Reinhartz3, Ginny Gildengorin4, Natalie Cvijanovich5
Congenital Heart Disease, Vol.15, No.4, pp. 229-238, 2020, DOI:10.32604/CHD.2020.011671
Abstract Purpose: To summarize Fontan procedure data from our institution,
UCSF Benioff Children’s Hospital Oakland, in order to better understand outcomes of our surgical and post-operative care. Basic Procedures: This is a retrospective cross-sectional chart review summarizing characteristics and outcomes of
patients who underwent the Fontan procedure at our institution between 2005 and
2016. Main Findings: Sixty-five Fontan procedures were performed at our institution between 2005 and 2016, all of which were extracardiac Fontan procedures
performed by the same surgical team. At the time of Fontan procedure, the mean
patient age was 56.4 ± 18.7 months and mean weight was 16.6… More >
Open Access
ARTICLE
Or Bercovich1, Tal Tirosh-Wagner2, Lior Goldberg1, Amir Vardi3, David Mishali4, Gideon Paret1,#, Yael Nevo-Caspi1,*,#
Congenital Heart Disease, Vol.15, No.4, pp. 239-249, 2020, DOI:10.32604/CHD.2020.011576
Abstract Objective: To test the hypothesis that circulating miRNAs-146a, -146b,
-155, and -21 reflect the inflammatory state of children following heart surgery,
and that they may, therefore, correlate with postoperative parameters. We aimed
to quantify miRNAs in blood samples from pediatric patients before and 6, 12,
and 24 hours after surgery and to evaluate correlations between the miRNA levels
and the postoperative course. Setting: PICU. Patients: Forty-two pediatric
patients with CHD who underwent cardiac surgery at Safra Children’s Hospital
between 2012–2016. Interventions: none. Outcome Measures: The primary outcomes were the postoperative cardiac complications and the secondary outcomes
were the length of… More >
Open Access
ARTICLE
Evan Pagano1, Benjamin Frank1, James Jaggers2, Mark Twite3, Tracy T. Urban4, Jelena Klawitter2,#, Jesse Davidson1,#,*
Congenital Heart Disease, Vol.15, No.4, pp. 251-265, 2020, DOI:10.32604/CHD.2020.012219
Abstract Objectives: (1) To measure the global shift in the metabolome in
hypoxemic versus non-hypoxemic infants with congenital heart disease; (2) To
identify metabolites and metabolic pathways that are altered in hypoxemia. Study
Design: Analysis of serum samples obtained prior to cardiopulmonary bypass
from 82 infants ≤120 days old with congenital heart disease requiring surgery
at Children’s Hospital Colorado. Infants were divided into groups based on preoperative oxygen saturations: non-hypoxemic (>92%), mild hypoxemia
(85–92%), and severe hypoxemia (<85%). Tandem mass spectrometry was used
to analyze 165 targeted metabolites. Partial least squares discriminant analysis and
t-tests were used to determine differences among… More >
Open Access
CASE REPORT
Alejandro R. Peirone1,*, Alejandro E. Contreras2, Carolina Carrizo2, Mailén Konicoff2, Raúl O. Cayre3
Congenital Heart Disease, Vol.15, No.4, pp. 267-274, 2020, DOI:10.32604/CHD.2020.013199
Abstract A 43-year-old woman with a past medical history of aortic coarctation
surgically repaired at the age of 3 years using an end-to-end anastomosis, presented with 2 years complain of increasing dyspnea and fatigue with exercise
associated to frequent palpitations. During extensive work-up, she was found to
have a partial anomalous pulmonary venous connection (PAPVC) with “dual drainage” represented by a communication between the right pulmonary veins draining into the left atrium and the innominate vein via an anomalous vein due to a
persistence of early connections between the sinus of the right pulmonary veins
and the cardinal veins system in… More >
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