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Intestinal Epithelial Cells in Health and Disease

Submission Deadline: 31 December 2022 (closed)

Guest Editors

Prof. Weiqi He, Soochow University, China.


A single layer of epithelial cells lines the inner surface of the intestine. The continuous proliferation of stem cells at the bottom of crypt maintains the renewal of epithelial cells. Epithelial cells form a barrier which excludes external agents from entering the internal environment of the body and inducing inflammation. Importantly, epithelial survival and mucosal barrier function are the core of pathogenesis of intestinal diseases such as inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CA-CRC). In this special issue, we welcome manuscripts that address issues of intestinal stem cell biology, epithelial regeneration, and epithelial barrier function in health and disease states.


Areas of interest include, but are not limited to:

Intestinal stem cells

Intestinal organoids

Epithelial barrier function

Epithelial cell death

Mucosal immunology

Inflammatory bowel disease

Colitis-associated colorectal cancer

Colorectal cancer

Gut microbiota

Circadian clock and gut homeostasis


Intestinal Stem Cell, Barrier Function, Inflammatory Bowel Disease, Colitis, Colorectal Cancer, Circadian Clock, Organoids

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