Guest Editors
Prof. Weiqi He, Soochow University, China. whe@suda.edu.cn
Summary
A single layer of epithelial cells lines the inner surface of the intestine. The continuous proliferation of stem cells at the bottom of crypt maintains the renewal of epithelial cells. Epithelial cells form a barrier which excludes external agents from entering the internal environment of the body and inducing inflammation. Importantly, epithelial survival and mucosal barrier function are the core of pathogenesis of intestinal diseases such as inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CA-CRC). In this special issue, we welcome manuscripts that address issues of intestinal stem cell biology, epithelial regeneration, and epithelial barrier function in health and disease states.
Areas of interest include, but are not limited to:
Intestinal stem cells
Intestinal organoids
Epithelial barrier function
Epithelial cell death
Mucosal immunology
Inflammatory bowel disease
Colitis-associated colorectal cancer
Colorectal cancer
Gut microbiota
Circadian clock and gut homeostasis
Keywords
Intestinal Stem Cell, Barrier Function, Inflammatory Bowel Disease, Colitis, Colorectal Cancer, Circadian Clock, Organoids
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