Table of Content

Tissue Engineering, Cellular Therapy and Biotechnologies in Plastic Surgery

Submission Deadline: 31 December 2022 Submit to Special Issue

Guest Editors


Prof. Dr. Pietro Gentile, Associate Professor of Plastic Surgery, Surgical Science Department, University of Rome “Tor Vergata”, Italy. pietrogentile2004@libero.it

Summary

This Special Issue is devoted to recent advances in tissue engineering and plastic surgery focusing on the development of new autologous and/or mini-invasive procedures. Clinical advantages exist for the development of procedures based on minimal and/or extensive manipulation (the last one only in GMP lab) to enhance plastic surgery techniques traditionally based on the flap, graft, prostheses. To acquire this, advances in tissue engineering have to revolve around the improvement of mini-invasive technology prevalently based on minimal manipulation. In this case, Combined or not combined use Autologous Platelet-Rich Plasma (PRP), Micro-Needling Technique (MN-T), Fat Grafting, Adipose-derived Mesenchymal Stem Cells (AD-MSCs), human follicle stem cells (HFSCs), Human Adipose Tissue-Derived Follicle Stem Cells (H-AT-d-FSCs) and Biomaterials to enhance soft tissue defects (breast, face, buttock), hair re-growth and lower extremity ulcers appear to be fundamentals. Also, the potential use of AD-MSCs in COVID-19 as recently reported should be discussed.


A special focus must be dedicated to the innovative use of these manipulations (minimal and/or extensive) procedures.


For this Special Issue, we welcome submissions exploring cutting-edge research and recent advances in wound healing, hair science, breast reconstruction/augmentation, face rejuvenation, buttock augmentation, and COVID-19 syndrome treatment. Studies comprising new strategies based on autologous and/or mini-invasive procedures, related also to regenerative strategies as PRP, HFSCs, H-AT-d-FSCs, AD-MSCs, MN-T Fat Grafting, Biomaterials and the development of new approaches are welcome, as are comprehensive review/systematic review papers.


Keywords

Platelet-Rich Plasma (PRP), Adipose-Derived Mesenchymal Stem Cells (AD-MSCs), Hair Re-Growth, Wound Healing, Soft Tissue Defects, Fat Grafting, Human Follicle Stem Cells (HFSCs), Regenerative Plastic Surgery, Tissue Engineering, COVID-19

Published Papers


  • Open Access

    REVIEW

    Surface activity of cancer cells: The fusion of two cell aggregates

    IVANA PAJIC-LIJAKOVIC, MILAN MILIVOJEVIC
    BIOCELL, Vol.47, No.1, pp. 15-25, 2023, DOI:10.32604/biocell.2023.023469
    (This article belongs to this Special Issue: Tissue Engineering, Cellular Therapy and Biotechnologies in Plastic Surgery)
    Abstract A key feature that distinguishes cancer cells from all other cells is their capability to spread throughout the body. Although how cancer cells collectively migrate by following molecular rules which influence the state of cell-cell adhesion contacts has been comprehensively formulated, the impact of physical interactions on cell spreading remains less understood. Cumulative effects of physical interactions exist as the interplay between various physical parameters such as (1) tissue surface tension, (2) viscoelasticity caused by collective cell migration, and (3) solid stress accumulated in the cell aggregate core region. This review aims to point out the role of these physical… More >

  • Open Access

    ARTICLE

    ZBTB7A governs 2-DG-inhibited glycolysis by regulating GLUT1 in nasopharyngeal carcinoma

    FEI LIU, JIAZHANG WEI, JIAO LAN, YONGLI WANG, JIANXIANG YE, CHENG Su, MINGZHENG MO, FENGZHU TANG, BING LI, MIN LI, WEIMING DENG, LINSONG YE, Wenlin HUANG, JINGJIN WENG, WEI JIAO, SHENHONG QU
    BIOCELL, Vol.46, No.12, pp. 2659-2669, 2022, DOI:10.32604/biocell.2022.022886
    (This article belongs to this Special Issue: Tissue Engineering, Cellular Therapy and Biotechnologies in Plastic Surgery)
    Abstract Our previous studies suggested a potential interaction between the POK erythroid myeloid ontogenic factor ZBTB7A and glucose transporter 1 (GLUT1) in nasopharyngeal carcinoma (NPC). This study was designed to confirm the interaction and further evaluate the precise mechanism by which ZBTB7A and GLUT1 regulate NPC development. The binding sites between ZBTB7A and the promoter of GLUT1 were predicted by bioinformatics. Gene expression was measured by quantitative real-time polymerase chain reaction (qPCR), western blotting, and immunohistochemistry. The activities of key glycolysis enzymes, including hexokinase (HK), pyruvate kinase (PK), lactate dehydrogenase (LDH), and lactate, were detected using specific enzyme-linked immunosorbent assay kits.… More >

  • Open Access

    ARTICLE

    A nanostructured look of collagen apatite porosity into human mineralized collagen fibril

    FABIANO BINI, ANDRADA PICA, ANDREA MARINOZZI, FRANCO MARINOZZI
    BIOCELL, Vol.46, No.10, pp. 2225-2229, 2022, DOI:10.32604/biocell.2022.021150
    (This article belongs to this Special Issue: Tissue Engineering, Cellular Therapy and Biotechnologies in Plastic Surgery)
    Abstract Bone tissue is a hierarchical material characterized at nanoscale by the mineralized collagen fibril, a recurring structure mainly composed of apatite minerals, collagen and water. Bone nanostructure has a fundamental role in determining the mechanical behavior of the tissue and its mass transport properties. Diffusion phenomenon allows to maintain an adequate supply of metabolites in the mechanisms of bone remodeling, adaptation and repair. Several analytical and computational models have been developed to analyze and predict bone tissue behavior. However, the fine replication of the natural tissue still represents a challenge. Insights on the structural organization at nanoscale and on the… More >

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