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Tissue plasminogen activator for neonatal coronary thrombosis presenting with mitral valve regurgitation and impaired ventricular function

Delaram Molkara, Jose A. Silva Sepulveda, Thomas Do, Christopher Davis, Gregory P. Goldstein, John W. Moore, Howaida G El-Said

Rady Children’s Hospital, San Diego, University of California, San Diego, California, USA

* Corresponding Author: Delaram Molkara, MD, 3020 Children’s Way, Rady Children’s Hospital, San Diego, California, 92123, USA. Email: email

Congenital Heart Disease 2017, 12(3), 270-274. https://doi.org/10.1111/chd.12432

Abstract

Objective: Neonatal coronary thrombosis is a rarely reported disorder, with variable outcomes described. This study assessed the feasibility and safety of an institutional protocol using tissue plasminogen activator (tPA) administration for the treatment of neonatal coronary artery thrombi.
Methods: They reviewed the outcome of three neonates with clinical evidence of myocardial infarction secondary to coronary thrombosis. All three underwent the tPA treatment protocol.
Results: The three described cases presented at 5 hours, 15 hours, and 10 days of life. The patients identified underwent the tPA protocol at least once. There was clinical evidence of improvement in coronary flow, as well as demonstration of increased left ventricular function and decreased mitral regurgitation. No major adverse events occurred.
Conclusion: Thrombolytic therapy with this tPA protocol may be safe and effective in treating neonates with coronary thrombosis.

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Cite This Article

APA Style
Molkara, D., Sepulveda, J.A.S., Do, T., Davis, C., Goldstein, G.P. et al. (2017). Tissue plasminogen activator for neonatal coronary thrombosis presenting with mitral valve regurgitation and impaired ventricular function. Congenital Heart Disease, 12(3), 270-274. https://doi.org/10.1111/chd.12432
Vancouver Style
Molkara D, Sepulveda JAS, Do T, Davis C, Goldstein GP, Moore JW, et al. Tissue plasminogen activator for neonatal coronary thrombosis presenting with mitral valve regurgitation and impaired ventricular function. Congeni Heart Dis. 2017;12(3):270-274 https://doi.org/10.1111/chd.12432
IEEE Style
D. Molkara et al., "Tissue plasminogen activator for neonatal coronary thrombosis presenting with mitral valve regurgitation and impaired ventricular function," Congeni. Heart Dis., vol. 12, no. 3, pp. 270-274. 2017. https://doi.org/10.1111/chd.12432



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