Open Access
REVIEW
State of the art review: Chemotherapy-induced cardiotoxicity in children
Robert W. Loar, Cory V. Noel, Hari Tunuguntla, John L. Colquitt, Ricardo H. Pignatelli
Pediatric Cardiology, Texas Children’s Hospital/Baylor College of Medicine, Houston, Texas, USA
* Corresponding Author: Robert W. Loar, MD, Texas Children’s Hospital/Baylor College of Medicine, 6621 Fannin Street, MC 19345-C, Houston, TX 77030, USA. Email:
Congenital Heart Disease 2018, 13(1), 5-15. https://doi.org/10.1111/chd.12564
Abstract
Chemotherapy-induced cardiotoxicity in adults and children is a topic with a growing interest in
the cardiology literature. The ability to detect cardiac dysfunction in a timely manner is essential in
order to begin adequate treatment and prevent further deterioration. This article aims to provide a
review on the myocardial injury process, chemotherapeutic agents that lead to cardiotoxicity, the
definition of cardiotoxicity, and the methods of timely detection and treatment.
Keywords
Cite This Article
Loar, R. W., Noel, C. V., Tunuguntla, H., Colquitt, J. L., Pignatelli, R. H. (2018). State of the art review: Chemotherapy-induced cardiotoxicity in children.
Congenital Heart Disease, 13(1), 5–15.