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REVIEW

State of the art review: Chemotherapy-induced cardiotoxicity in children

Robert W. Loar, Cory V. Noel, Hari Tunuguntla, John L. Colquitt, Ricardo H. Pignatelli
Pediatric Cardiology, Texas Children’s Hospital/Baylor College of Medicine, Houston, Texas, USA
* Corresponding Author: Robert W. Loar, MD, Texas Children’s Hospital/Baylor College of Medicine, 6621 Fannin Street, MC 19345-C, Houston, TX 77030, USA. Email:

Congenital Heart Disease 2018, 13(1), 5-15. https://doi.org/10.1111/chd.12564

Abstract

Chemotherapy-induced cardiotoxicity in adults and children is a topic with a growing interest in the cardiology literature. The ability to detect cardiac dysfunction in a timely manner is essential in order to begin adequate treatment and prevent further deterioration. This article aims to provide a review on the myocardial injury process, chemotherapeutic agents that lead to cardiotoxicity, the definition of cardiotoxicity, and the methods of timely detection and treatment.

Keywords

anthracyclines, cardiotoxicity, chemotherapy, congestive heart failure, pediatrics

Cite This Article

Loar, R. W., Noel, C. V., Tunuguntla, H., Colquitt, J. L., Pignatelli, R. H. (2018). State of the art review: Chemotherapy-induced cardiotoxicity in children. Congenital Heart Disease, 13(1), 5–15.



This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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