Table of Content

Open AccessOpen Access


Cardiovascular outcomes of pregnancy in Marfan’s syndrome patients: A literature review

So Yeon Kim1,2, Diana S. Wolfe2, Cynthia C. Taub2

1 Tufts Medical Center, Boston, Massachusetts, USA
2 Montefiore Medical Center, Bronx, New York, USA

* Corresponding Author: So Yeon Kim, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA. Email:

Congenital Heart Disease 2018, 13(2), 203-209.


Aims: Pregnancy in patients with Marfan’s syndrome (MFS) carries an increased risk of cardiovascular complications, resulting in increased maternal and fetal mortality and morbidity. Literature on MFS pregnant patients is relatively sparse, and there has yet to be a concrete consensus on the management of this unique patient population. The purpose of our paper is to provide a literature review of case reports and studies on MFS during pregnancy (published between 2005 and 2015) and to explore cardiovascular outcomes of patients with MFS.
Methods and Results: Of the 852 women in our review, there were 1112 pregnancies, with an aortic dissection rate of 7.9% and mortality of 1.2%. Data demonstrated a trend that patients whose aortic diameter ≥40 mm had a greater rate of dissection than MFS patients whose aortic diameter <40 mm (Fisher’s exact test, P = .0504). Fetal outcome included a 5.6% mortality rate and 41% of births were cesarean deliveries and of those reported, 75% secondary to cardiac emergencies.
Conclusions: Patients with MFS, especially those whose initial aortic diameters ≥40 mm, planning a pregnancy or currently pregnant should be carefully counseled about the maternal and fetal risks throughout pregnancy. MFS patients whose aortic diameters ≥40 mm should be advised to ideally await pregnancy until prophylactic aortic surgery. As MFS varies in its phenotypic expression, each patient’s risk of adverse cardiac events should be assessed individually through a joint Maternal Fetal Medicine and Cardiology Center.


Cite This Article

Kim, S. Y., Wolfe, D. S., Taub, C. C. (2018). Cardiovascular outcomes of pregnancy in Marfan’s syndrome patients: A literature review. Congenital Heart Disease, 13(2), 203–209.

This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
  • 994


  • 705


  • 0


Share Link