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Hemodynamic Profiling Using a Cardiac Index–Systemic Vascular Resistance Plot in Patients with Fontan Circulation

Yuki Kawasaki1,*, Takeshi Sasaki1, Daisuke Kobayashi2

1 Division of Pediatric Cardiology, Osaka City General Hospital Pediatric Medical Center, Osaka, 5340021, Japan
2 Division of Cardiology, St. Louis Children’s Hospital, Department of Pediatrics, Washington University in St. Louis, St. Louis, MO 63130, USA

* Corresponding Author: Yuki Kawasaki. Email: email-hp.or.jp

Congenital Heart Disease 2023, 18(4), 431-445. https://doi.org/10.32604/chd.2023.030910

Abstract

Background: Elevated Fontan pressure (FP) alone cannot fully predict clinical outcomes. We hypothesized that hemodynamic profiling using a cardiac index (CI)-systemic vascular resistance (SVR) plot could characterize clinical features and predict the prognosis of post-Fontan patients. Methods: We included post-Fontan patients who underwent cardiac catheterization at age < 10 years. Patients were classified into four categories: A, CI  ≥ 3, SVR index (SVRI) ≥ 20; B, CI < 3, SVRI ≥ 20; C, CI ≥ 3, SVRI < 20; and D, CI < 3, SVRI < 20. The primary outcome was freedom from the combined endpoint: new onset of protein-losing enteropathy or plastic bronchitis, heart transplant, and death. Clinical and hemodynamic variables and freedom from the endpoint were compared between the hemodynamic categories and outcome predictors were evaluated. Results: Eighty-three patients were included. Median follow-up was 5.3 years. Category A/B/C/D consisted of 4/15/53/11 patients, respectively. All the patients in category A were New York Heart Association I/II and had a significantly lower pulmonary vascular resistance index (PVRI). Patients in category C had lower pulmonary/systemic blood flow. Patients in category D had a higher PVRI and had the poorest freedom from the endpoint (44% at 5 years). Elevated FP and category D were outcome predictors. Conclusions: CI-SVR plots was a novel adjunctive method for Fontan hemodynamic profiling.

Graphic Abstract

Hemodynamic Profiling Using a Cardiac Index–Systemic Vascular Resistance Plot in Patients with Fontan Circulation

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APA Style
Kawasaki, Y., Sasaki, T., Kobayashi, D. (2023). Hemodynamic profiling using a cardiac index–systemic vascular resistance plot in patients with fontan circulation. Congenital Heart Disease, 18(4), 431-445. https://doi.org/10.32604/chd.2023.030910
Vancouver Style
Kawasaki Y, Sasaki T, Kobayashi D. Hemodynamic profiling using a cardiac index–systemic vascular resistance plot in patients with fontan circulation. Congeni Heart Dis. 2023;18(4):431-445 https://doi.org/10.32604/chd.2023.030910
IEEE Style
Y. Kawasaki, T. Sasaki, and D. Kobayashi "Hemodynamic Profiling Using a Cardiac Index–Systemic Vascular Resistance Plot in Patients with Fontan Circulation," Congeni. Heart Dis., vol. 18, no. 4, pp. 431-445. 2023. https://doi.org/10.32604/chd.2023.030910



cc Copyright © 2023 The Author(s). Published by Tech Science Press.
This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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