Open Access

ARTICLE

An Assisted Diagnosis of Alzheimer’s Disease Incorporating Attention Mechanisms Med-3D Transfer Modeling

Yanmei Li^1,*, Jinghong Tang¹, Weiwu Ding¹, Jian Luo², Naveed Ahmad³, Rajesh Kumar⁴

1 School of Artificial Intelligence, Chongqing University of Technology, Chongqing, 400054, China
2 Computer School, China West Normal University, Nanchong, 637009, China
3 Department of Computer Science, Prince Sultan University, Riyadh, 11586, Saudi Arabia
4 Yangtze Delta Region Institute (Huzhou), University of Electronic Science and Technology of China, Huzhou, 313001, China

* Corresponding Author: Yanmei Li. Email:

Computers, Materials & Continua 2024, 78(1), 713-733. https://doi.org/10.32604/cmc.2023.046872

Received 17 October 2023; Accepted 21 November 2023; Issue published 30 January 2024

Abstract

Alzheimer’s disease (AD) is a complex, progressive neurodegenerative disorder. The subtle and insidious onset of its pathogenesis makes early detection of a formidable challenge in both contemporary neuroscience and clinical practice. In this study, we introduce an advanced diagnostic methodology rooted in the Med-3D transfer model and enhanced with an attention mechanism. We aim to improve the precision of AD diagnosis and facilitate its early identification. Initially, we employ a spatial normalization technique to address challenges like clarity degradation and unsaturation, which are commonly observed in imaging datasets. Subsequently, an attention mechanism is incorporated to selectively focus on the salient features within the imaging data. Building upon this foundation, we present the novel Med-3D transfer model, designed to further elucidate and amplify the intricate features associated with AD pathogenesis. Our proposed model has demonstrated promising results, achieving a classification accuracy of 92%. To emphasize the robustness and practicality of our approach, we introduce an adaptive ‘hot-updating’ auxiliary diagnostic system. This system not only enables continuous model training and optimization but also provides a dynamic platform to meet the real-time diagnostic and therapeutic demands of AD.

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Keywords

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