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ABSTRACT

Fluid-Structure Interaction Human Carotid Plaque Progression Simulation Using 3D Meshless Generalized Finite Difference Models Based on Patient-Tracking In Vivo MRI Data

Dalin Tang1, Chun Yang2, Satya Atluri3

Corresponding author, dtangwpi.edu, Worcester Polytechnic Institute, Worcester, MA 016091
School of Mathematical Sciences, Beijing Normal University, Key Laboratory of Mathematicsand Complex Systems, Ministry of Education, Beijing, 100875, China
Center of Aerospace Research & Education, University of California, Irvine, CA 92612.

The International Conference on Computational & Experimental Engineering and Sciences 2011, 18(3), 67-68. https://doi.org/10.3970/icces.2011.018.067

Abstract

Cardiovascular disease is the leading cause of death worldwide. Many victims of the disease died suddenly without prior symptoms. It is a great challenge for clinicians and researchers to develop screening techniques and assessment methodologies to identify those patients for early treatment and prevention of the fatal clinical event. Considerable effort has been devoted investigating mechanisms governing atherosclerotic plaque progression and rupture [Friedman, Bargeron, Deters, Hutchins and Mark (1987); Friedman and Giddens (2005); Giddens, Zarins, Glagov, S. (1993); Ku, Giddens, Zarins and Glagov (1985); Gibson et al. (1993); Liu and Tang (2010); Stone et al. (2003); Yang, Tang, Atluri et al. (2008,2010)]. Previously, we introduced a computational procedure based on three-dimensional meshless generalized finite difference (MGFD) method and serial magnetic resonance imaging (MRI) data to quantify patient-specific carotid atherosclerotic plaque growth functions and simulate plaque progression. Structure-only models were used in our previous report [Yang, Tang, Atluri et al. (2010)]. In this paper, a meshless modeling procedure for fluid-structure interaction (FSI) human carotid plaque progression simulation using 3D generalized finite difference (GFD) models was introduced based on multi-year patient-tracking in vivo magnetic resonance imaging (MRI) data. Multi-year patient-tracking data was obtained three times (T1, T2, and T3, at intervals of about 18 months) to obtain plaque progression data after informed consent. Blood flow was assumed to laminar, Newtonian, viscous and incompressible. Plaque material was assumed to be uniform, homogeneous, isotropic, linear, and nearly incompressible. Meshless GFD FSI models were constructed and validated by ADINA for the plaque at T1, T2 and T3 to obtain plaque wall (structure) stress and flow shear stress to determine plaque growth functions which were used in progression simulation. Four growth functions with various combinations of morphology, plaque wall stress (PWS) and flow shear stress (FSS) were quantified using least-squares approximation and T1 and T2 data to fit T3 plaque morphology.

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APA Style
Tang, D., Yang, C., Atluri, S. (2011). Fluid-structure interaction human carotid plaque progression simulation using 3D meshless generalized finite difference models based on patient-tracking in vivo MRI data. The International Conference on Computational & Experimental Engineering and Sciences, 18(3), 67-68. https://doi.org/10.3970/icces.2011.018.067
Vancouver Style
Tang D, Yang C, Atluri S. Fluid-structure interaction human carotid plaque progression simulation using 3D meshless generalized finite difference models based on patient-tracking in vivo MRI data. Int Conf Comput Exp Eng Sciences . 2011;18(3):67-68 https://doi.org/10.3970/icces.2011.018.067
IEEE Style
D. Tang, C. Yang, and S. Atluri "Fluid-Structure Interaction Human Carotid Plaque Progression Simulation Using 3D Meshless Generalized Finite Difference Models Based on Patient-Tracking In Vivo MRI Data," Int. Conf. Comput. Exp. Eng. Sciences , vol. 18, no. 3, pp. 67-68. 2011. https://doi.org/10.3970/icces.2011.018.067



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