Vol.24, No.2, 2022, pp.295-307, doi:10.32604/oncologie.2022.022116
OPEN ACCESS
ARTICLE
Chinese Herbal Prescription QYSL Prevents Progression of Lung Cancer by Targeting Tumor Microenvironment
  • Yang Chen1,#, Huan Wu2,#, Annan Jiao3, Jiabing Tong4, Jie Zhu5, Mei Zhang1, Zegeng Li4,*, Ping Li1,*
1 Oncology Department of Integrated Traditional Chinese and Western Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China
2 Scientific Research & Experiment Center, Anhui University of Chinese Medicine, Hefei, 230038, China
3 The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China
4 The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, 230601, China
5 College of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, 230038, China
* Corresponding Authors: Ping Li. Email: ; Zegeng Li. Email:
# These authors contributed equally to this work
Received 22 February 2022; Accepted 14 April 2022; Issue published 29 June 2022
Abstract
Objectives: Lung cancer is a common and malignant tumor in adults and ranks first in the incidence and mortality of the top five malignant tumors in China. Our previous studies have shown that QYSL prescription can balance lung cancer mice Th1/Th2 and inhibit tumor cell immune escape. Here, we examined the effects of QYSL on lung cancer associated macrophage and the potential associated mechanism. Methods: C57BL/6 mice were injected with Lewis lung cancer cells and treated with QYSL. FACS, RT-PCR, and western blot were used to examined the effect of QYSL on tumor immune microenvironment. Results: We found QYSL inhibited tumor growth in mice with lung cancer. Further study indicated that QYSL inhibited growth of lung tumor by promoting T cell activation and promoting macrophage polarization to M1 type. We found QYSL could markedly inhibit M2 macrophage related protein expression and promote M1 macrophage related protein expression. Additionally, STAT6 and MTOR expression were reduced in QYSL group. Conclusions: Overall, this study indicated that QYSL potently inhibited the growth of lung cancer by promoting T cell activation and M2 macrophage polarization to M1, which was found to be associated with the STAT6 and MTOR signaling pathway.
Keywords
Lung cancer; TME; traditional Chinese medicine; QYSL
Cite This Article
Chen, Y., Wu, H., Jiao, A., Tong, J., Zhu, J. et al. (2022). Chinese Herbal Prescription QYSL Prevents Progression of Lung Cancer by Targeting Tumor Microenvironment. Oncologie, 24(2), 295–307.
This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.