Open Access iconOpen Access

REVIEW

crossmark

Advances in Targeted Therapy Against Driver Mutations and Epigenetic Alterations in Non-Small Cell Lung Cancer

Jiajian Shi1, Yuchen Chen1,*, Chentai Peng1, Linwu Kuang2, Zitong Zhang1, Yangkai Li2,*, Kun Huang1

1 Tongji School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
2 Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

* Corresponding Authors: Yuchen Chen. Email: email; Yangkai Li. Email: email

Oncologie 2022, 24(4), 613-648. https://doi.org/10.32604/oncologie.2022.027545

Abstract

The incidence and mortality of lung cancer rank top three of all cancers worldwide. Accounting for 85% of the total number of lung cancer, non-small cell lung cancer (NSCLC) is an important factor endangering human health. Recently, targeted therapies against driver mutations and epigenetic alterations have made encouraging advances that benefit NSCLC patients. Druggable driver mutations, which mainly occur in EGFR, KRAS, MET, HER2, ALK, ROS1, RET and BRAF, have been identified in more than a quarter of NSCLC patients. A series of highly selective mutant targeting inhibitors, such as EGFR tyrosine kinase inhibitors and KRAS inhibitors, have been well studied and applied in clinical treatments, which greatly promote the overall survival of NSCLC patients. However, drug resistance has become a major challenge for targeted treatment, and a variety of methods to overcome drug resistance are constantly being developed, including inhibitors against new mutants, combination therapy with other pathway inhibitors, etc. In addition, epigenetics-based therapy is emerging. Epigenetic regulators such as histone deacetylases and non-coding RNA play a crucial role in the development of cancer and drug resistance by affecting multiple signaling pathways. Epigenetics-based therapeutic strategies combined with targeted drugs show great clinical potential. Many agents targeting epigenetic changes are being investigated in preclinical studies, with some already under clinical trials. This article focuses on driver mutations and epigenetic alterations in association with relevant epidemiological data. We introduce the current status of targeted inhibitors and known drug resistance, review advances in major targeted therapies with recent data from preclinical and clinical trials, and discuss the possibility of combination therapy against driver mutations and epigenetic alterations in overcoming drug resistance.

Keywords


Cite This Article

APA Style
Shi, J., Chen, Y., Peng, C., Kuang, L., Zhang, Z. et al. (2022). Advances in targeted therapy against driver mutations and epigenetic alterations in non-small cell lung cancer. Oncologie, 24(4), 613-648. https://doi.org/10.32604/oncologie.2022.027545
Vancouver Style
Shi J, Chen Y, Peng C, Kuang L, Zhang Z, Li Y, et al. Advances in targeted therapy against driver mutations and epigenetic alterations in non-small cell lung cancer. Oncologie . 2022;24(4):613-648 https://doi.org/10.32604/oncologie.2022.027545
IEEE Style
J. Shi et al., "Advances in Targeted Therapy Against Driver Mutations and Epigenetic Alterations in Non-Small Cell Lung Cancer," Oncologie , vol. 24, no. 4, pp. 613-648. 2022. https://doi.org/10.32604/oncologie.2022.027545



cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
  • 2263

    View

  • 1084

    Download

  • 19

    Like

Share Link