Heni Radiani Arifin^1,*, Yoan Christina Angelica¹, Bambang Nurhadi¹, Herlina Marta¹, Rossy Choerun Nissa²

Journal of Renewable Materials, Vol.13, No.3, pp. 617-635, 2025, DOI:10.32604/jrm.2025.057812 - 20 March 2025

Abstract Bionanocomposite film is produced from renewable and biodegradable natural resources. Although elephant foot yam (EFY) starch (Amorphophallus paeoniifolius) is a promising polymer for bionanocomposite film, the native hydrophilic properties influence the overall performance characteristics. Incorporating virgin coconut oil (VCO) and monoglyceride as hydrophobic components can improve mechanical properties and reduce permeability while increasing the hydrophobicity of the composite. Therefore, this study aimed to determine the effect of adding VCO and monoglyceride on EFY starch-nanocrystalline film at 3 and 5 wt% concentrations. Experimental tests were conducted to evaluate the physical and mechanical properties, water vapor transmission rate… More > Graphic Abstract

Sayeda M. Abdo^1,*, Mehrez E. El-Naggar², Islam El Nagar³, Samar A. El-Mekkawi⁴, Youssef A. M.^3,5

Journal of Renewable Materials, Vol.13, No.3, pp. 599-616, 2025, DOI:10.32604/jrm.2024.057736 - 20 March 2025

Abstract The accumulation of non-biodegradable plastic debris in the environment raises serious concerns about potential long-term effects on the environment, the economy, and waste management. To assess the feasibility of substituting commercial plastics for a biodegradable renewable polymer for many applications, low-density polyethylene (LDPE) was mixed with varying concentrations of algal biomass (AB). Algae are considered a clean, renewable energy source because they don’t harm the environment and can be used to create bioplastics. Algal biomass grown in a high rate algal pond (HRAP) used for wastewater treatment used at 12.5–50 weight percent. Mechanical, thermal,… More > Graphic Abstract

Mohamad Firdaus Omar¹, Fathilah Ali^1,*, Mohammed Saedi Jami¹, Azlin Suhaida Azmi¹, Farah Ahmad¹, Mohd Zahid Marzuki², Shantha Kumari Muniyandi³, Zuraidah Zainudin⁴, Minsoo P. Kim⁵

Journal of Renewable Materials, Vol.13, No.3, pp. 497-538, 2025, DOI:10.32604/jrm.2024.057248 - 20 March 2025

Abstract This review provides a comprehensive overview of natural rubber (NR) composites, focusing on their properties, compounding aspects, and renewable practices involving natural fibre reinforcement. The properties of NR are influenced by the compounding process, which incorporates ingredients such as elastomers, vulcanizing agents, accelerators, activators, and fillers like carbon black and silica. While effective in enhancing properties, these fillers lack biodegradability, prompting the exploration of sustainable alternatives. The potential of natural fibres as renewable reinforcements in NR composites is thoroughly covered in this review, highlighting both their advantages, such as improved sustainability, and the challenges they More > Graphic Abstract

Luthfi Hakim^1,*, Apri Heri Iswanto^1,*, Yunida Syafriani Lubis², Adam Jagwani Wirawan¹, Ridwanti Batubara¹, Nam Hum Kim³, Petar Antov⁴, Tomasz Rogoziński⁵, Lee Seng Hua⁶, Lum Wei Chen⁷, Rangabhashiyam Selvasembian⁸, Jayusman², Jajang Sutiawan⁹

Journal of Renewable Materials, Vol.13, No.3, pp. 637-650, 2025, DOI:10.32604/jrm.2025.056365 - 20 March 2025

Abstract The utilisation of sugar palm bunches-charcoal briquettes (SPB-CB) represents a significant advancement in biomass energy. This study aimed to analyse the properties of charcoal briquettes produced from SPB (Arenga longipes). The experiment involved categorising the dimensions of charcoal powder into three specific particle sizes: 20–40 mesh, 40–60 mesh, and particles that could pass through a 60-mesh screen. The charcoal powder will be combined with tapioca as a binding agent at three specific concentrations: 11%, 13%, and 15%. The research findings indicate that the samples underwent 60 mesh passes achieved the maximum briquette density, with an average… More >

AMJAD YOUSUF¹, NAJEEB ULLAH KHAN^2,*

Oncology Research, Vol.33, No.4, pp. 851-861, 2025, DOI:10.32604/or.2025.058956 - 19 March 2025

Abstract Breast cancer is a significant global concern, with limited effective treatment options. Therefore, therapies with high efficacy and low complications, unlike the existing chemotherapies, are urgently required. To address this issue, advances have been made in therapies targeting molecular pathways related to the murine double minute 2 proto-oncogene (MDM2)-tumor proteinp53 (TP53) interaction. This review aims to investigate the efficacy of MDM2 inhibition in restoring TP53 activity in breast cancer cells, as evidenced by clinical studies, reviews, and trials. TP53 is a tumor suppressor and MDM2 facilitates proteasomal degradation of TP53. MDM2 and TP53 activity More > Graphic Abstract

BIAO WU^1,#, XIANLIN GUO^2,#, ZHISHI WU¹, LIANG CHEN^1,*, SUQING ZHANG^3,*

Oncology Research, Vol.33, No.4, pp. 975-988, 2025, DOI:10.32604/or.2025.058085 - 19 March 2025

Abstract Objectives: Although Yes-associated protein 1 (YAP1) is an important oncogene in hepatocellular carcinoma (HCC) progression, its nuclear localization prevents it from being considered a potential therapeutic target. Recently, studies have reported that coatomer protein complex subunit beta 2 (COPB2) also plays a critical role in HCC development; however its mechanism of action is unclear. This study aimed to investigate the role of COPB2 and YAP1 in the progression of HCC and to elucidate the underlying mechanisms. Methods: COPB2 and YAP1 expression in HCC tissues were first analyzed by database searches and immunohistochemistry. Nomogram and artificial… More >

MICHELE MAFFEZZOLI^1,2,#, GIULIA CLAIRE GIUDICE^1,2,#,*, GIACOMO IOVANE^1,2, MARTINA MANINI^1,2, ELENA RAPACCHI¹, GIUSEPPE CARUSO¹, NICOLA SIMONI³, STEFANIA FERRETTI⁴, STEFANO PULIATTI⁴, DAVIDE CAMPOBASSO⁵, SEBASTIANO BUTI^1,2

Oncology Research, Vol.33, No.4, pp. 741-757, 2025, DOI:10.32604/or.2024.057278 - 19 March 2025

Abstract Background: immune checkpoint inhibitors (ICIs) have revolutionized the treatment of metastatic urothelial carcinoma (mUC), significantly improving survival outcomes. However, a subset of patients do not respond to ICIs, prompting research into potential predictive factors. Commonly prescribed medications such as corticosteroids, proton-pump inhibitors (PPIs), antibiotics (Abs), antihypertensives, and analgesics may influence ICI effectiveness. Methods: we conducted a literature search on PubMed to investigate the impact of concomitant medications on the outcomes of patients with mUC, treated with ICIs. We selected the most relevant studies and performed a narrative review. Results: corticosteroids, PPIs and Abs have been associated More >

KONTIC MILICA^1,2,*, MARKOVIC FILIP¹

Oncology Research, Vol.33, No.4, pp. 781-793, 2025, DOI:10.32604/or.2024.057231 - 19 March 2025

Abstract Detecting lung cancer early is crucial for improving survival rates, yet it remains a significant challenge due to many cases being diagnosed at advanced stages. This review aims to provide advances in epigenetics which have highlighted DNA methylation patterns as promising biomarkers for early detection, prognosis, and treatment response in lung cancer. Techniques like bisulfite conversion followed by PCR, digital droplet polymerase chain reaction, and next-generation sequencing are commonly used for detecting these methylation patterns, which occur early in the cancer development process and can be detected in non-invasive samples like blood and sputum. Key… More >

DEMEI FENG^1,#, SHENRUI BAI^1,#, GUANJUN CHEN¹, BIBO FU¹, CAILU SONG¹, HAILIN TANG¹, LIANG WANG^2,*, HUA WANG^1,*

Oncology Research, Vol.33, No.4, pp. 965-974, 2025, DOI:10.32604/or.2024.057065 - 19 March 2025

Abstract Objectives: The optimal treatment strategy for early-stage natural killer/T-cell lymphoma (NKTCL) remains unclear. This study aimed to evaluate and compare the clinical outcomes and adverse events (AEs) associated with two treatment regimens for early-stage NKTCL: pegaspargase with concurrent radiation therapy (P+CCRT) and pegaspargase, gemcitabine, and oxaliplatin (P-GEMOX) with sequential radiation therapy (SERT). Propensity score matching (PSM) was employed to ensure balanced comparison between these regimens. Methods: We assessed the efficacy of P+CCRT from a phase II trial and P-GEMOX combined with SERT using real-world data. PSM was conducted at a 1:1 ratio with a caliper… More >

Oncology Research Editorial Office

Oncology Research, Vol.33, No.4, pp. 993-993, 2025, DOI:10.32604/or.2024.056915 - 19 March 2025

Abstract This article has no abstract. More >