Jie Wu^∗,†, Quan Long^‡, Shixiong Xu^*, Anwar R. Padhani^§, Yuping Jiang^¶

Molecular & Cellular Biomechanics, Vol.5, No.4, pp. 217-228, 2008, DOI:10.3970/mcb.2008.005.217

Abstract In this paper, a 3D mathematical model of tumour angiogenesis is developed, to generate a functional tumour vasculature for blood microcirculation. The model follows that of Anderson and Chaplain (1998) ^[1] with three exceptions: (a) extending the model from 2D to 3D, one arteriole and one venule is induced as two parent vessels to form an intact circulation network for blood flow; (b) generating networks able to penetrate into the tumour interior rather than the exterior only; (c) considering branching generations with different diameters, based on which three groups of vessels, such as arterioles, venules and… More >

A. Shukla^1,1, A.R. Dunn^2,2, M.A. Moses^3,3, K.J. Van Vliet^4,4

Molecular & Cellular Biomechanics, Vol.1, No.4, pp. 279-290, 2004, DOI:10.3970/mcb.2004.001.279

Abstract Although it is established that endothelial cells can respond to external mechanical cues (e.g., alignment in the direction of fluid shear stress), the extent to which mechanical stress and strain applied via the endothelial cell substrate impact biomolecular and cellular processes is not well-understood. This issue is particularly important in the context of inflammation, vascular remodeling, and cancer progression, as each of these processes occurs concurrently with localized increases in strain and marked changes in molecules secreted by adjacent cells. Here, we systematically vary the level and duration of cyclic tensile strain applied to human… More >