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  • Open Access

    ARTICLE

    Exosomes Derived From Hypoxic Colorectal Cancer Cells Promote Angiogenesis Through Wnt4-Induced β-Catenin Signaling in Endothelial Cells

    Zhe Huang, Yong Feng

    Oncology Research, Vol.25, No.5, pp. 651-661, 2017, DOI:10.3727/096504016X14752792816791

    Abstract Cancer cell-derived exosomes have been actively released into the tumor microenvironment with pleiotropic roles in tumor growth and metastasis, including angiogenesis and immune modulation. However, the functions and underlying mechanisms of exosomes shed by colorectal cancer (CRC) cells under hypoxic conditions remain unknown. Here we found that exosomes derived from hypoxic CRC cells promoted the proliferation and migration of endothelial cells. Suppression of exosome secretion through RAB27a knockdown in CRC cells inhibited exosomal-induced proliferation and migration of endothelial cells. Furthermore, we discovered that these exosomes enriched with Wnt4 were dependent on HIF1α. Exosomal Wnt4 increased More >

  • Open Access

    ARTICLE

    Shear Stress and Oxidized LDL Regulates Endothelial Cell Tube Formation through VEGF Signaling

    Bo Ling1,#, Daoxi Lei1,#, Juhui Qiu1, Kang Zhang1, Hao Chen2,*, Yeqi Wang1, Zhiyi Ye1, Guixue Wang*

    Molecular & Cellular Biomechanics, Vol.14, No.4, pp. 197-211, 2017, DOI:10.3970/mcb.2017.014.197

    Abstract Shear stress and oxidized low-density lipoprotein (oxLDL) caused by abnormal blood is critical to angiogenesis for atherosclerosis. However, the mechanism in shear stress or ox-LDL regulated angiogenesis is still not well understood. There is the hypothesis that shear stress or oxLDL regulates angiogenesis through the vascular endothelial growth factor (VEGF) signaling pathway. It is discovered that both high shear stress and low concentration of oxLDL contribute to angiogenesis, which is inhibited once the VEGF or VEGFR expression is knocked down. The expression of p-FAK and p-paxillin is regulated by the VEGF/VEGFR signal axis. VEGFR2, p-FAK, More >

  • Open Access

    ARTICLE

    Shear Stress-mediated Angiogenesis Through Id1 Relevant to Atherosclerosis

    Yidan Chen#,1, Kang Zhang#,1, Juhui Qiu1, Shicheng He1, Junyang Huang2, Lu Huang1, Dongyu Jia3, Bo Ling1, Da Sun4, Xiang Xie1, Tieying Yin*,1, Guixue Wang*,1

    Molecular & Cellular Biomechanics, Vol.14, No.2, pp. 83-100, 2017, DOI:10.3970/mcb.2017.014.081

    Abstract Abnormal shear stress in the blood vessel is an important stimulating factor for the formation of angiogenesis and vulnerable plaques. This paper intended to explore the role of shear stress-regulated Id1 in angiogenesis. First, we applied a carotid artery ring ligation to create local stenosis in ApoE-/- mice. Then, 3D geometry of the vessel network was reconstructed based on MRI, and our analysis of computational fluid dynamics revealed that wall shear stress of the proximal region was much higher than that of the distal region. In addition, results from histological staining of the proximal region found More >

  • Open Access

    ARTICLE

    ERK Signaling Pathway Is Involved in HPV-16 E6 but not E7 Oncoprotein-Induced HIF-1α Protein Accumulation in NSCLC Cells

    Fei Liu*1, Bihua Lin*1, Xin Liu*, Wenzhang Zhang*, Erying Zhang*, Liang Hu*, Yuefan Ma*, Xiangyong Li*, Xudong Tang*†

    Oncology Research, Vol.23, No.3, pp. 109-118, 2015, DOI:10.3727/096504015X14496932933610

    Abstract Extracellular signal-regulated kinase (ERK)1/2 signaling pathway plays a critical role in regulating tumor angiogenesis. Our previous studies have demonstrated that HPV-16 oncoproteins enhanced hypoxia-inducible factor-1α (HIF-1α) protein accumulation and vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8) expression in non-small cell lung cancer (NSCLC) cells, thus contributing to angiogenesis. In this study, we further investigated the role of ERK1/2 signaling pathway in HPV-16 oncoprotein-induced HIF-1α, VEGF, and IL-8 expression and in vitro angiogenesis in NSCLC cells. Our results showed that HPV-16 E6 and HPV-16 E7 oncoproteins promoted the activation of ERK1/2 signaling pathway in A549 More >

  • Open Access

    ARTICLE

    Simulation of 3D Solid Tumour Angiogenesis Including Arteriole, Capillary and Venule

    Jie Wu∗,†, Quan Long, Shixiong Xu*, Anwar R. Padhani§, Yuping Jiang

    Molecular & Cellular Biomechanics, Vol.5, No.4, pp. 217-228, 2008, DOI:10.3970/mcb.2008.005.217

    Abstract In this paper, a 3D mathematical model of tumour angiogenesis is developed, to generate a functional tumour vasculature for blood microcirculation. The model follows that of Anderson and Chaplain (1998) [1] with three exceptions: (a) extending the model from 2D to 3D, one arteriole and one venule is induced as two parent vessels to form an intact circulation network for blood flow; (b) generating networks able to penetrate into the tumour interior rather than the exterior only; (c) considering branching generations with different diameters, based on which three groups of vessels, such as arterioles, venules and… More >

  • Open Access

    ARTICLE

    Endothelial cells as mechanical transducers: Enzymatic activity and network formation under cyclic strain

    A. Shukla1,1, A.R. Dunn2,2, M.A. Moses3,3, K.J. Van Vliet4,4

    Molecular & Cellular Biomechanics, Vol.1, No.4, pp. 279-290, 2004, DOI:10.3970/mcb.2004.001.279

    Abstract Although it is established that endothelial cells can respond to external mechanical cues (e.g., alignment in the direction of fluid shear stress), the extent to which mechanical stress and strain applied via the endothelial cell substrate impact biomolecular and cellular processes is not well-understood. This issue is particularly important in the context of inflammation, vascular remodeling, and cancer progression, as each of these processes occurs concurrently with localized increases in strain and marked changes in molecules secreted by adjacent cells. Here, we systematically vary the level and duration of cyclic tensile strain applied to human… More >

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