YUAN SONG1,#, CAI WEI2,#, JINGJING WANG3,*
BIOCELL, Vol.45, No.3, pp. 733-744, 2021, DOI:10.32604/biocell.2021.013236
Abstract Oxidative stress-mediated cell death in cardiomyocytes contributes to the development of atrial fibrillation.
However, the detailed mechanisms are still unclear. In the present study, we established atrial fibrillation models in
mice. The cardiomyocytes were isolated from atrial fibrillation mice and normal mice and were cultured in vitro,
respectively. The results showed that cell proliferation and viability in cardiomyocytes with atrial fibrillation were
significantly lower than the cells from the normal mice. Consistently, atrial fibrillation cardiomyocytes were prone to
suffer from apoptotic cell death. Also, the oxidative stress and ferroptosis-associated signatures were significantly
increased in atrial fibrillation cardiomyocytes compared to normal… More >
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