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  • Open Access


    A novel mutation in ROR2 led to the loss of function of ROR2 and inhibited the osteogenic differentiation capability of bone marrow mesenchymal stem cells (BMSCs)


    BIOCELL, Vol.47, No.7, pp. 1561-1569, 2023, DOI:10.32604/biocell.2023.028851

    Abstract Background: Receptor tyrosine kinase-like orphan receptor 2 (ROR2) has a vital role in osteogenesis. However, the mechanism underlying the regulation of ROR2 in osteogenic differentiation is still poorly comprehended. A previous study by our research group showed that a novel compound heterozygous ROR2 variation accounted for the autosomal recessive Robinow syndrome (ARRS). This study attempted to explore the impact of the ROR2: c.904C>T variant specifically on the osteogenic differentiation of BMSCs. Methods: Coimmunoprecipitation (CoIP)-western blotting was carried out to identify the interaction between ROR2 and Wnt5a. Double-immunofluorescence staining was used for determining the expressions and co-localization… More > Graphic Abstract

    A novel mutation in <i>ROR2</i> led to the loss of function of <i>ROR2</i> and inhibited the osteogenic differentiation capability of bone marrow mesenchymal stem cells (BMSCs)

  • Open Access


    Handling Big Data in Relational Database Management Systems

    Kamal ElDahshan1, Eman Selim2, Ahmed Ismail Ebada2, Mohamed Abouhawwash3,4, Yunyoung Nam5,*, Gamal Behery2

    CMC-Computers, Materials & Continua, Vol.72, No.3, pp. 5149-5164, 2022, DOI:10.32604/cmc.2022.028326

    Abstract Currently, relational database management systems (RDBMSs) face different challenges in application development due to the massive growth of unstructured and semi-structured data. This introduced new DBMS categories, known as not only structured query language (NoSQL) DBMSs, which do not adhere to the relational model. The migration from relational databases to NoSQL databases is challenging due to the data complexity. This study aims to enhance the storage performance of RDBMSs in handling a variety of data. The paper presents two approaches. The first approach proposes a convenient representation of unstructured data storage. Several extensive experiments were More >

  • Open Access


    Long non-coding RNA MIR22HG inhibits the adipogenesis of human bone marrow mesenchymal stem cells with the involvement of Wnt/β-catenin pathway


    BIOCELL, Vol.46, No.7, pp. 1717-1724, 2022, DOI:10.32604/biocell.2022.018706

    Abstract Osteoporosis is a frequently occurring bone remodeling disorder worldwide with one characteristic being decreasing bone mineral density and a predisposition to bone fracture, which diminishes patients’ quality of life. Several studies showed that imbalance between the osteogenesis and adipogenesis of bone marrow mesenchymal stem cells (BMSCs) took part in the development of osteoporosis. In previous study, we found MIR22HG regulated the osteogenesis of human BMSCs positively. In this study, we found that MIR22HG was decreased during the adipogenesis of human BMSCs and exerted negative effects on adipogenesis with the involvement of Wnt/β-catenin signaling pathway both in More >

  • Open Access


    Cyclic biaxial tensile strain enhances osteogenic differentiation in rat bone marrow-derived mesenchymal stem cells via activating ERα-Wnt3a/β-catenin pathway


    BIOCELL, Vol.46, No.6, pp. 1465-1472, 2022, DOI:10.32604/biocell.2022.018967

    Abstract The present study was designed to investigate the role of estrogen receptor α (ERα) in biaxial tensile strain (BTS) regulated osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells (rBMSCs). rBMSCs were derived from rats and overexpressed ERα. The rBMSCs were subjected to BTS at 1 Hz with a strain of 2% for 4 h per day, 3 days, with or without ERα inhibitor ICI 182,780 (ICI). Then, bone mineralization was performed by Alizarin Red Staining. The markers of osteogenic differentiation and downstream Wnt3a/β-catenin signaling were detected by western blotting. Results showed that BTS enhanced More >

  • Open Access


    Synergy of single-cell sequencing analyses and in vivo lineage-tracing approaches: A new opportunity for stem cell biology


    BIOCELL, Vol.46, No.5, pp. 1157-1162, 2022, DOI:10.32604/biocell.2022.018960

    Abstract Single-cell sequencing technologies have rapidly progressed in recent years, and been applied to characterize stem cells in a number of organs. Somatic (postnatal) stem cells are generally identified using combinations of cell surface markers and transcription factors. However, it has been challenging to define micro-heterogeneity within “stem cell” populations, each of which stands at a different level of differentiation. As stem cells become defined at a single-cell level, their differentiation path becomes clearly defined. Here, this viewpoint discusses the potential synergy of single-cell sequencing analyses with in vivo lineage-tracing approaches, with an emphasis on practical considerations More >

  • Open Access


    A New Database Intrusion Detection Approach Based on Hybrid Meta-Heuristics

    Youseef Alotaibi*

    CMC-Computers, Materials & Continua, Vol.66, No.2, pp. 1879-1895, 2021, DOI:10.32604/cmc.2020.013739

    Abstract A new secured database management system architecture using intrusion detection systems (IDS) is proposed in this paper for organizations with no previous role mapping for users. A simple representation of Structured Query Language queries is proposed to easily permit the use of the worked clustering algorithm. A new clustering algorithm that uses a tube search with adaptive memory is applied to database log files to create users’ profiles. Then, queries issued for each user are checked against the related user profile using a classifier to determine whether or not each query is malicious. The IDS… More >

  • Open Access


    A Lightweight Approach to Access to Wireless Network without Operating System Support

    Yonghua Xionga,b,d, Jinhua Shea,b,c, Keyuan Jiangd

    Intelligent Automation & Soft Computing, Vol.24, No.2, pp. 275-284, 2018, DOI:10.1080/10798587.2017.1280262

    Abstract Wireless network is crucial for the Mobile Transparent Computing (MTC), in which a mobile device without any Operating System (OS) support needs to load the demanded OSes and applications through accessing the wireless network connection. In this paper, a lightweight approach based on the Boot Management System (BMS) was proposed to ensure the wireless network connection before booting OS. In BMS, the Virtual File System (VFS) technology was used to drive the wireless network card and establish a stable network connection. A prototype of the BMS was tested on ARM11 hardware platform and the results More >

  • Open Access


    Uniform Query Framework for Relational and NoSQL Databases

    J.B. Karanjekar1, M.B. Ch,ak2

    CMES-Computer Modeling in Engineering & Sciences, Vol.113, No.2, pp. 177-187, 2017, DOI:10.3970/cmes.2017.113.177

    Abstract As the data managed by applications has evolved over the years with the arrival of Web 2.0, a large number of new databases have been developed to manage various types of data. While the traditional relational databases continue to exist, NoSQL databases which are document oriented or key-value stores or columnar continue to evolve and are embraced very rapidly across the industry. It is not just the type of data handled by these databases that is different but also the query language they use is also different. This paper talks about a uniform query framework More >

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